ISMARA results: GLI3

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GLI3

Z-value: 1.84

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Transcription factors associated with GLI3

Gene Symbol	Gene ID	Gene Info
GLI3 Ensembl NCBI GeneCards UniProt	ENSG00000106571.15	GLI3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GLI3	hg38_v1_chr7_-_42152396_42152440, hg38_v1_chr7_-_42152444_42152458, hg38_v1_chr7_-_42237187_42237216	0.68	6.0e-31	Click!

Activity profile of GLI3 motif

Sorted Z-values of GLI3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLI3

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Promoter	Score	Transcript	Gene	Gene Info
chr9_-_95317671 Show fit	46.31	ENST00000490972.7 ENST00000647778.1 ENST00000649611.1 ENST00000289081.8	FANCC Ensembl NCBI GeneCards UniProt Show fit	FA complementation group C
chr22_-_19524400 Show fit	38.79	ENST00000618236.2	CLDN5 Ensembl NCBI GeneCards UniProt Show fit	claudin 5
chr8_-_27605271 Show fit	35.01	ENST00000522098.1	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr5_-_42825884 Show fit	33.72	ENST00000506577.5	SELENOP Ensembl NCBI GeneCards UniProt Show fit	selenoprotein P
chr8_-_27611325 Show fit	33.57	ENST00000523500.5	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr19_+_44914702 Show fit	32.81	ENST00000592885.5 ENST00000589781.1	APOC1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein C1
chr19_-_20661563 Show fit	31.11	ENST00000601440.6 ENST00000291750.6 ENST00000595094.1	ZNF626 Ensembl NCBI GeneCards UniProt Show fit ENSG00000269110.1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 626 novel transcript
chr19_-_20661507 Show fit	30.38	ENST00000612591.4 ENST00000595405.1	ZNF626 Ensembl NCBI GeneCards UniProt Show fit	zinc finger protein 626
chr19_+_44914588 Show fit	28.69	ENST00000592535.6	APOC1 Ensembl NCBI GeneCards UniProt Show fit	apolipoprotein C1
chr12_+_78864768 Show fit	28.43	ENST00000261205.9 ENST00000457153.6	SYT1 Ensembl NCBI GeneCards UniProt Show fit	synaptotagmin 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	109.5	GO:0043547	positive regulation of GTPase activity(GO:0043547)
25.7	102.9	GO:0010900	negative regulation of phosphatidylcholine catabolic process(GO:0010900)
18.1	90.7	GO:1902998	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.3	76.4	GO:0015701	bicarbonate transport(GO:0015701)
1.5	72.0	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
2.5	69.0	GO:0097150	neuronal stem cell population maintenance(GO:0097150)
10.0	60.1	GO:0070829	response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
7.9	55.1	GO:0070560	protein secretion by platelet(GO:0070560)
6.8	47.9	GO:0086047	membrane depolarization during Purkinje myocyte cell action potential(GO:0086047)
2.5	43.0	GO:0007021	tubulin complex assembly(GO:0007021)

Showing 1 to 10 of 381 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	126.3	GO:0005615	extracellular space(GO:0005615)
6.9	111.0	GO:0042583	chromaffin granule(GO:0042583)
4.1	102.8	GO:0042627	chylomicron(GO:0042627)
1.3	89.8	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
2.9	71.3	GO:0031095	platelet dense tubular network membrane(GO:0031095)
4.4	70.0	GO:0097512	cardiac myofibril(GO:0097512)
0.2	53.3	GO:0001726	ruffle(GO:0001726)
1.5	47.9	GO:0034706	sodium channel complex(GO:0034706)
0.2	45.7	GO:0009897	external side of plasma membrane(GO:0009897)
3.7	44.4	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)

Showing 1 to 10 of 163 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.4	102.8	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
3.9	90.7	GO:0051787	misfolded protein binding(GO:0051787)
1.1	66.7	GO:0030507	spectrin binding(GO:0030507)
2.1	62.4	GO:0005212	structural constituent of eye lens(GO:0005212)
10.0	60.1	GO:0004489	methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.5	59.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
2.8	56.2	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
4.3	55.6	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.3	51.2	GO:0017137	Rab GTPase binding(GO:0017137)
7.7	38.3	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)

Showing 1 to 10 of 273 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	110.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
1.1	54.7	PID BARD1 PATHWAY	BARD1 signaling events
0.1	40.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	38.0	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.2	36.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.5	35.3	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.7	30.0	PID S1P S1P3 PATHWAY	S1P3 pathway
1.3	29.7	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.6	27.1	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.6	27.0	PID RAS PATHWAY	Regulation of Ras family activation

Showing 1 to 10 of 79 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	70.4	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
2.7	67.4	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.3	66.2	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
1.4	62.1	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	53.9	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.3	52.1	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.5	45.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.2	43.3	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3	35.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.3	35.1	REACTOME THROMBOXANE SIGNALLING THROUGH TP RECEPTOR	Genes involved in Thromboxane signalling through TP receptor

Showing 1 to 10 of 109 entries

Results for GLI3

Z-value: 1.84

Motif logo

Transcription factors associated with GLI3

Activity-expression correlation:

Activity profile of GLI3 motif

Sorted Z-values of GLI3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLI3

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: