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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GLIS2
Z-value: 0.99
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Transcription factors associated with GLIS2
Network of associatons between targets according to the STRING database.
First level regulatory network of GLIS2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 24.6 | GO:0071787 | endoplasmic reticulum tubular network assembly(GO:0071787) |
| 6.9 | 20.7 | GO:0014810 | positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014810) |
| 0.5 | 15.9 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 1.0 | 15.2 | GO:0070986 | left/right axis specification(GO:0070986) |
| 4.8 | 14.4 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.2 | 14.2 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 3.3 | 13.1 | GO:0018231 | peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231) |
| 2.2 | 13.1 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 1.3 | 12.7 | GO:0016127 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 4.2 | 12.5 | GO:1901388 | regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 25.0 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.0 | 16.0 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.6 | 13.9 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 2.2 | 13.1 | GO:0002178 | palmitoyltransferase complex(GO:0002178) |
| 4.2 | 12.5 | GO:1990917 | sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917) |
| 0.2 | 11.5 | GO:0032592 | integral component of mitochondrial membrane(GO:0032592) |
| 0.2 | 11.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 1.3 | 10.7 | GO:0061700 | GATOR2 complex(GO:0061700) |
| 0.9 | 10.6 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.1 | 10.6 | GO:0035579 | specific granule membrane(GO:0035579) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 47.2 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) |
| 4.1 | 20.7 | GO:0045174 | glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
| 0.6 | 14.8 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.2 | 14.2 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.2 | 14.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.4 | 13.7 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.9 | 13.1 | GO:0022820 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.7 | 13.1 | GO:0019706 | protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707) |
| 4.2 | 12.5 | GO:0002135 | CTP binding(GO:0002135) |
| 0.1 | 11.3 | GO:0042393 | histone binding(GO:0042393) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 44.5 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.1 | 15.1 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.2 | 13.3 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.4 | 9.4 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.3 | 6.9 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.3 | 6.2 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 5.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 4.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.0 | 4.7 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 3.4 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 35.0 | REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING | Genes involved in p75 NTR receptor-mediated signalling |
| 0.6 | 20.7 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.7 | 18.2 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.2 | 13.2 | REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | Genes involved in SCF-beta-TrCP mediated degradation of Emi1 |
| 0.7 | 12.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 12.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 12.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.5 | 11.5 | REACTOME ACTIVATION OF BH3 ONLY PROTEINS | Genes involved in Activation of BH3-only proteins |
| 0.3 | 10.7 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.6 | 10.6 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |