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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GLIS3
Z-value: 0.60
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Transcription factors associated with GLIS3
Network of associatons between targets according to the STRING database.
First level regulatory network of GLIS3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_+_52949107 Show fit | 25.82 |
ENST00000388835.4
|
keratin 18 |
|
| chr1_-_45522870 Show fit | 16.76 |
ENST00000424390.2
|
peroxiredoxin 1 |
|
| chr19_+_48325323 Show fit | 16.56 |
ENST00000596315.5
|
epithelial membrane protein 3 |
|
| chr1_-_45521854 Show fit | 14.68 |
ENST00000372079.1
ENST00000319248.13 |
peroxiredoxin 1 |
|
| chr1_-_45521931 Show fit | 13.35 |
ENST00000447184.6
ENST00000262746.5 |
peroxiredoxin 1 |
|
| chr17_-_75182536 Show fit | 12.64 |
ENST00000578238.2
|
small ubiquitin like modifier 2 |
|
| chr18_+_3451585 Show fit | 11.00 |
ENST00000551541.5
|
TGFB induced factor homeobox 1 |
|
| chr5_+_172959416 Show fit | 10.29 |
ENST00000265100.6
ENST00000519239.5 |
ribosomal protein L26 like 1 |
|
| chr18_+_3451647 Show fit | 8.51 |
ENST00000345133.9
ENST00000330513.10 ENST00000549546.5 |
TGFB induced factor homeobox 1 |
|
| chrX_+_65667645 Show fit | 8.29 |
ENST00000360270.7
|
moesin |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 44.8 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 0.7 | 30.4 | GO:0097284 | hepatocyte apoptotic process(GO:0097284) |
| 0.0 | 22.4 | GO:0071363 | cellular response to growth factor stimulus(GO:0071363) |
| 0.8 | 16.6 | GO:0032060 | bleb assembly(GO:0032060) |
| 0.2 | 15.4 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.3 | 15.3 | GO:0070911 | global genome nucleotide-excision repair(GO:0070911) |
| 0.0 | 11.6 | GO:0002283 | neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312) |
| 2.1 | 10.5 | GO:0015862 | uridine transport(GO:0015862) |
| 0.7 | 10.4 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.6 | 8.6 | GO:0070986 | left/right axis specification(GO:0070986) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 44.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.6 | 25.8 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 15.4 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 15.3 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 11.4 | GO:0035579 | specific granule membrane(GO:0035579) |
| 0.0 | 10.5 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.2 | 8.6 | GO:0097542 | ciliary tip(GO:0097542) |
| 0.1 | 8.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.4 | 8.3 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.7 | 4.8 | GO:1990635 | proximal dendrite(GO:1990635) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.6 | 44.8 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.9 | 25.8 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.7 | 19.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 15.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.1 | 15.3 | GO:0031386 | protein tag(GO:0031386) |
| 0.1 | 11.3 | GO:0005496 | steroid binding(GO:0005496) |
| 0.1 | 10.6 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.5 | 10.5 | GO:0005337 | nucleoside transmembrane transporter activity(GO:0005337) |
| 0.1 | 8.3 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 1.6 | 7.9 | GO:0004966 | galanin receptor activity(GO:0004966) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 44.2 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.3 | 25.8 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 19.0 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 18.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 10.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.3 | 6.7 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 4.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 3.7 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 3.0 | PID IL27 PATHWAY | IL27-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 19.5 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 15.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.2 | 10.5 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.2 | 8.3 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 8.2 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 6.7 | REACTOME INFLAMMASOMES | Genes involved in Inflammasomes |
| 0.0 | 3.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 3.0 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.0 | 2.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 1.8 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |