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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GMEB1
Z-value: 1.04
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Transcription factors associated with GMEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GMEB1 | hg38_v1_chr1_+_28668746_28668815 | 0.22 | 8.6e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GMEB1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 36.9 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
| 0.2 | 36.0 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.2 | 28.1 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 3.0 | 24.3 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 1.7 | 23.5 | GO:1904869 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 0.3 | 22.2 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.3 | 21.9 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 5.3 | 21.2 | GO:0019860 | uracil metabolic process(GO:0019860) |
| 0.5 | 19.9 | GO:0043029 | T cell homeostasis(GO:0043029) |
| 0.4 | 15.0 | GO:0006294 | nucleotide-excision repair, preincision complex assembly(GO:0006294) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 38.4 | GO:0015934 | large ribosomal subunit(GO:0015934) |
| 0.0 | 36.8 | GO:0005730 | nucleolus(GO:0005730) |
| 0.1 | 31.5 | GO:0005819 | spindle(GO:0005819) |
| 1.4 | 26.9 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 26.1 | GO:0005813 | centrosome(GO:0005813) |
| 0.5 | 25.6 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 0.7 | 18.9 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.6 | 18.8 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.1 | 17.6 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.1 | 13.9 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 37.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 30.8 | GO:0003723 | RNA binding(GO:0003723) |
| 2.2 | 28.6 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 0.1 | 27.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.5 | 23.3 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 1.8 | 17.9 | GO:1990948 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 0.5 | 17.7 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 0.3 | 17.4 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 1.5 | 13.2 | GO:0031730 | CCR5 chemokine receptor binding(GO:0031730) |
| 0.2 | 13.0 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.4 | 25.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 20.8 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.2 | 13.3 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.2 | 12.9 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.2 | 12.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 12.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.3 | 11.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.1 | 9.8 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.2 | 8.7 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 49.9 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.2 | 35.2 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.2 | 35.1 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.5 | 35.0 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 1.3 | 30.2 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.7 | 23.5 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.6 | 20.4 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 1.3 | 20.1 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.6 | 17.4 | REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX | Genes involved in Activation of the pre-replicative complex |
| 0.8 | 13.3 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |