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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GMEB2
Z-value: 2.38
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Transcription factors associated with GMEB2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GMEB2 | hg38_v1_chr20_-_63627049_63627113 | 0.29 | 1.3e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GMEB2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 245.2 | GO:0000377 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 2.5 | 243.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 2.6 | 197.2 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 1.3 | 189.0 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 11.3 | 158.5 | GO:0000492 | box C/D snoRNP assembly(GO:0000492) |
| 3.5 | 142.6 | GO:0006363 | termination of RNA polymerase I transcription(GO:0006363) |
| 2.7 | 112.3 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 1.6 | 100.0 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 15.0 | 90.0 | GO:0007296 | vitellogenesis(GO:0007296) |
| 1.5 | 85.9 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.1 | 193.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 1.8 | 186.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 6.1 | 172.0 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 20.2 | 161.2 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
| 6.8 | 143.0 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.8 | 142.0 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 8.2 | 131.8 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 1.3 | 121.1 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 1.1 | 117.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 2.0 | 95.6 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 233.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 7.8 | 219.4 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 15.6 | 187.1 | GO:1990247 | N6-methyladenosine-containing RNA binding(GO:1990247) |
| 0.1 | 163.6 | GO:0003723 | RNA binding(GO:0003723) |
| 8.2 | 131.8 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 11.1 | 100.1 | GO:0050145 | nucleoside phosphate kinase activity(GO:0050145) |
| 1.8 | 77.3 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 9.3 | 74.4 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.2 | 73.7 | GO:0005525 | GTP binding(GO:0005525) |
| 10.4 | 73.0 | GO:0034513 | box H/ACA snoRNA binding(GO:0034513) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 249.9 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.9 | 188.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 3.6 | 182.4 | PID MYC PATHWAY | C-MYC pathway |
| 1.6 | 110.7 | PID P53 REGULATION PATHWAY | p53 pathway |
| 1.5 | 103.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.5 | 54.7 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.8 | 49.7 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 1.3 | 42.9 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.5 | 41.5 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.4 | 41.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 253.6 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 1.8 | 201.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 1.9 | 189.1 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 1.4 | 134.2 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.8 | 130.0 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 5.9 | 124.4 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |
| 3.1 | 108.4 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 1.2 | 99.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.5 | 91.5 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 3.0 | 71.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |