Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for GRHL1
Z-value: 0.67
Motif logo
Transcription factors associated with GRHL1
Network of associatons between targets according to the STRING database.
First level regulatory network of GRHL1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_4338786 Show fit | 10.07 |
ENST00000601482.1
ENST00000600324.5 ENST00000594605.6 |
signal transducing adaptor family member 2 |
|
| chr1_-_112704921 Show fit | 9.81 |
ENST00000414971.1
ENST00000534717.5 |
ras homolog family member C |
|
| chr19_-_291132 Show fit | 9.38 |
ENST00000327790.7
|
phospholipid phosphatase 2 |
|
| chr2_-_208254232 Show fit | 9.21 |
ENST00000415913.5
ENST00000415282.5 ENST00000446179.5 |
isocitrate dehydrogenase (NADP(+)) 1 |
|
| chr11_+_706117 Show fit | 9.11 |
ENST00000533256.5
ENST00000614442.4 |
EPS8 like 2 |
|
| chr2_-_85414039 Show fit | 8.18 |
ENST00000447219.6
ENST00000409670.5 ENST00000409724.5 |
capping actin protein, gelsolin like |
|
| chr1_+_156061142 Show fit | 7.65 |
ENST00000361084.10
|
RAB25, member RAS oncogene family |
|
| chr5_+_126423176 Show fit | 7.38 |
ENST00000542322.5
ENST00000544396.5 |
GRAM domain containing 2B |
|
| chr5_+_126423122 Show fit | 7.01 |
ENST00000515200.5
|
GRAM domain containing 2B |
|
| chr5_+_126423363 Show fit | 6.91 |
ENST00000285689.8
|
GRAM domain containing 2B |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 11.3 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.1 | 10.1 | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) |
| 0.9 | 9.9 | GO:0042985 | negative regulation of amyloid precursor protein biosynthetic process(GO:0042985) |
| 2.0 | 9.8 | GO:1902766 | skeletal muscle satellite cell migration(GO:1902766) |
| 0.2 | 9.4 | GO:0046839 | phospholipid dephosphorylation(GO:0046839) |
| 3.1 | 9.2 | GO:0006097 | glyoxylate cycle(GO:0006097) |
| 0.7 | 9.1 | GO:1900029 | positive regulation of ruffle assembly(GO:1900029) |
| 0.5 | 8.2 | GO:0071803 | positive regulation of podosome assembly(GO:0071803) |
| 0.4 | 7.7 | GO:0031268 | pseudopodium organization(GO:0031268) |
| 0.4 | 6.8 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.3 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 12.9 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 11.6 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 9.9 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.1 | 9.1 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.2 | 8.6 | GO:0032420 | stereocilium(GO:0032420) |
| 0.7 | 8.2 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.3 | 7.7 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.7 | 6.7 | GO:0000220 | vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) |
| 0.0 | 5.5 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 21.3 | GO:0042802 | identical protein binding(GO:0042802) |
| 3.9 | 11.6 | GO:0005055 | laminin receptor activity(GO:0005055) |
| 0.1 | 9.9 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 9.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.6 | 9.4 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 3.1 | 9.2 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
| 0.3 | 9.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 8.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.3 | 7.7 | GO:0031489 | myosin V binding(GO:0031489) |
| 1.4 | 6.8 | GO:0003870 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 6.8 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 6.7 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.1 | 5.9 | PID TRAIL PATHWAY | TRAIL signaling pathway |
| 0.0 | 5.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 4.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 1.9 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 0.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.9 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.2 | 9.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.3 | 9.2 | REACTOME PEROXISOMAL LIPID METABOLISM | Genes involved in Peroxisomal lipid metabolism |
| 0.2 | 6.8 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.2 | 6.7 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.0 | 6.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 5.9 | REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS | Genes involved in Extrinsic Pathway for Apoptosis |
| 0.0 | 5.0 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.0 | 4.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 4.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |