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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GSC_GSC2
Z-value: 0.89
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Transcription factors associated with GSC_GSC2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| GSC2 | hg38_v1_chr22_-_19150292_19150292 | 0.55 | 1.3e-18 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of GSC_GSC2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 53.8 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 1.8 | 31.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.1 | 25.0 | GO:0043523 | regulation of neuron apoptotic process(GO:0043523) |
| 0.0 | 19.6 | GO:0048232 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
| 0.2 | 18.9 | GO:0005977 | glycogen metabolic process(GO:0005977) |
| 0.5 | 13.5 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.1 | 13.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.1 | 10.8 | GO:0007601 | visual perception(GO:0007601) |
| 0.1 | 10.7 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 0.6 | 9.5 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 38.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 2.0 | 31.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.0 | 26.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 19.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.3 | 13.5 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 12.5 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 9.3 | GO:0005901 | caveola(GO:0005901) |
| 0.4 | 9.2 | GO:0097381 | photoreceptor disc membrane(GO:0097381) |
| 0.3 | 9.2 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.1 | 8.5 | GO:1904724 | tertiary granule lumen(GO:1904724) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 53.8 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 1.3 | 39.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.5 | 24.6 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 23.2 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 2.4 | 18.9 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 17.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 14.0 | GO:0031404 | chloride ion binding(GO:0031404) |
| 1.1 | 9.8 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315) |
| 0.1 | 9.4 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.3 | 9.2 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 58.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.2 | 9.9 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 8.3 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.1 | 8.1 | PID ATR PATHWAY | ATR signaling pathway |
| 0.0 | 3.7 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 3.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 3.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 1.8 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 1.6 | ST GA12 PATHWAY | G alpha 12 Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 58.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.4 | 13.5 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.6 | 10.6 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.1 | 9.9 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.6 | 8.9 | REACTOME ACYL CHAIN REMODELLING OF PS | Genes involved in Acyl chain remodelling of PS |
| 0.1 | 8.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 8.3 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.2 | 6.9 | REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION | Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation |
| 0.0 | 5.5 | REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS | Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways |
| 0.0 | 5.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |