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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for GSC_GSC2

Z-value: 0.89

Motif logo

Transcription factors associated with GSC_GSC2

Gene Symbol Gene ID Gene Info
ENSG00000133937.5 GSC
ENSG00000063515.3 GSC2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GSC2hg38_v1_chr22_-_19150292_191502920.551.3e-18Click!

Activity profile of GSC_GSC2 motif

Sorted Z-values of GSC_GSC2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GSC_GSC2

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr17_-_55511434 40.68 ENST00000636752.1
small integral membrane protein 36
chr2_-_174847015 29.18 ENST00000650938.1
chimerin 1
chr2_-_174846405 24.66 ENST00000409597.5
ENST00000413882.6
chimerin 1
chr20_+_35968566 19.23 ENST00000373973.7
ENST00000349339.5
ENST00000489667.1
ENST00000538900.1
cyclic nucleotide binding domain containing 2
chr11_-_111923722 17.00 ENST00000527950.5
crystallin alpha B
chr4_+_153222402 16.78 ENST00000676335.1
ENST00000675146.1
tripartite motif containing 2
chr11_-_111912871 14.36 ENST00000528628.5
crystallin alpha B
chr4_+_153222307 13.33 ENST00000675899.1
ENST00000675611.1
ENST00000674872.1
ENST00000676167.1
tripartite motif containing 2
chr12_-_54588516 13.17 ENST00000547431.5
protein phosphatase 1 regulatory inhibitor subunit 1A
chr2_-_55269038 12.93 ENST00000417363.5
ENST00000412530.1
ENST00000366137.6
ENST00000420637.5
mitochondrial translational initiation factor 2
chr7_+_29122274 9.47 ENST00000582692.2
ENST00000644824.1
novel transcript, antisense to CPVL
chimerin 2
chr19_-_3772211 9.42 ENST00000555978.5
ENST00000555633.3
retina and anterior neural fold homeobox 2
chr9_+_100442271 9.30 ENST00000502978.1
MSANTD3-TMEFF1 readthrough
chrX_+_101078861 9.26 ENST00000372930.5
transmembrane protein 35A
chr7_-_98252117 9.18 ENST00000420697.1
ENST00000415086.5
ENST00000447648.7
tectonin beta-propeller repeat containing 1
chr1_+_20070156 8.86 ENST00000375108.4
phospholipase A2 group V
chr11_+_61755372 8.68 ENST00000265460.9
myelin regulatory factor
chr17_-_28576882 8.47 ENST00000395319.7
ENST00000581807.5
ENST00000226253.9
ENST00000584086.5
ENST00000395321.6
aldolase, fructose-bisphosphate C
chr19_-_35757009 8.42 ENST00000587965.1
ENST00000004982.6
heat shock protein family B (small) member 6
chr3_-_10505508 8.33 ENST00000643662.1
ENST00000397077.6
ENST00000360273.7
ATPase plasma membrane Ca2+ transporting 2
chrX_-_6228835 8.18 ENST00000381095.8
neuroligin 4 X-linked
chr10_-_102418748 7.78 ENST00000020673.6
pleckstrin and Sec7 domain containing
chr18_-_66604076 7.22 ENST00000540086.5
ENST00000580157.2
ENST00000262150.7
cadherin 19
chr19_+_7914823 7.11 ENST00000565886.2
transforming growth factor beta receptor 3 like
chr11_+_76445001 6.95 ENST00000533988.5
ENST00000524490.5
ENST00000334736.7
ENST00000533972.5
EMSY transcriptional repressor, BRCA2 interacting
chr11_+_67455352 6.92 ENST00000325656.7
calcium binding protein 4
chr14_-_100568475 6.88 ENST00000553553.6
brain enriched guanylate kinase associated
chr9_+_17135017 6.74 ENST00000380641.4
ENST00000380647.8
centlein
chr3_-_170908626 6.11 ENST00000295822.7
ENST00000474096.5
eukaryotic translation initiation factor 5A2
chr3_-_98522514 6.03 ENST00000503004.5
ENST00000506575.1
ENST00000513452.5
ENST00000515620.5
claudin domain containing 1
chr2_+_120013068 5.90 ENST00000443902.6
ENST00000263713.10
erythrocyte membrane protein band 4.1 like 5
chr12_-_54588636 5.74 ENST00000257905.13
protein phosphatase 1 regulatory inhibitor subunit 1A
chrX_+_136197020 5.64 ENST00000370676.7
four and a half LIM domains 1
chr14_-_100568070 5.64 ENST00000557378.6
ENST00000443071.6
ENST00000637646.1
brain enriched guanylate kinase associated
chr19_-_12723925 5.63 ENST00000425528.6
ENST00000589337.5
ENST00000588216.5
transportin 2
chr5_+_141489066 5.62 ENST00000252087.3
protocadherin gamma subfamily C, 5
chr5_+_161848112 5.56 ENST00000393943.10
gamma-aminobutyric acid type A receptor subunit alpha1
chr6_+_35342614 5.54 ENST00000337400.6
ENST00000311565.4
peroxisome proliferator activated receptor delta
chr17_-_42112674 5.53 ENST00000251642.8
ENST00000591220.5
DExH-box helicase 58
chr16_-_275908 5.51 ENST00000359740.6
ENST00000316163.9
ENST00000397770.8
regulator of G protein signaling 11
chr2_+_172928165 5.38 ENST00000535187.5
Rap guanine nucleotide exchange factor 4
chr5_-_147081428 4.93 ENST00000394413.7
protein phosphatase 2 regulatory subunit Bbeta
chr19_-_48044037 4.86 ENST00000293255.3
calcium binding protein 5
chr11_-_63015831 4.77 ENST00000430500.6
ENST00000336232.7
solute carrier family 22 member 8
chr12_+_77830886 4.73 ENST00000397909.7
ENST00000549464.5
neuron navigator 3
chr16_-_68236069 4.62 ENST00000473183.7
ENST00000565858.5
epithelial splicing regulatory protein 2
chr17_+_46590669 4.61 ENST00000398238.8
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
chr5_-_178996184 4.40 ENST00000650031.1
glutamate metabotropic receptor 6
chr2_-_70553638 4.28 ENST00000444975.5
ENST00000445399.5
ENST00000295400.11
ENST00000418333.6
transforming growth factor alpha
chr5_+_161848314 4.23 ENST00000437025.6
gamma-aminobutyric acid type A receptor subunit alpha1
chrX_+_12137409 4.20 ENST00000672010.1
FERM and PDZ domain containing 4
chr11_-_70717994 4.17 ENST00000659264.1
SH3 and multiple ankyrin repeat domains 2
chr10_+_100462969 4.13 ENST00000343737.6
Wnt family member 8B
chr8_-_132111159 4.06 ENST00000673615.1
ENST00000434736.6
HERV-H LTR-associating 1
chr5_-_149944744 4.06 ENST00000255266.10
ENST00000617647.4
ENST00000613228.1
phosphodiesterase 6A
chr5_-_33984636 3.92 ENST00000382102.7
ENST00000509381.1
solute carrier family 45 member 2
chr7_+_138797952 3.81 ENST00000397602.7
ENST00000442682.7
ENST00000458494.1
ENST00000413208.1
transmembrane protein 213
chr17_+_49575828 3.79 ENST00000328741.6
neurexophilin 3
chr11_-_62984957 3.77 ENST00000377871.7
ENST00000360421.9
solute carrier family 22 member 6
chr2_-_240820945 3.75 ENST00000428768.2
ENST00000650053.1
ENST00000650130.1
kinesin family member 1A
chr4_+_70028452 3.69 ENST00000530128.5
ENST00000381057.3
ENST00000673563.1
histatin 3
chr15_+_64460728 3.68 ENST00000416172.1
zinc finger protein 609
chr15_-_26939518 3.68 ENST00000541819.6
gamma-aminobutyric acid type A receptor subunit beta3
chr19_-_49017087 3.49 ENST00000649238.3
luteinizing hormone subunit beta
chr19_-_42427379 3.48 ENST00000244289.9
lipase E, hormone sensitive type
chr17_-_9905248 3.41 ENST00000226193.6
recoverin
chr1_+_113905156 3.40 ENST00000650596.1
DNA cross-link repair 1B
chr6_+_35342535 3.39 ENST00000360694.8
ENST00000418635.6
ENST00000448077.6
peroxisome proliferator activated receptor delta
chr7_-_128775793 3.33 ENST00000249389.3
opsin 1, short wave sensitive
chr13_+_73058993 3.32 ENST00000377687.6
Kruppel like factor 5
chr10_-_75109172 3.22 ENST00000372700.7
ENST00000473072.2
ENST00000491677.6
ENST00000372702.7
dual specificity phosphatase 13
chr5_-_147081462 3.14 ENST00000508267.5
ENST00000504198.5
protein phosphatase 2 regulatory subunit Bbeta
chr3_-_49021045 3.12 ENST00000440857.5
DALR anticodon binding domain containing 3
chr10_-_75109085 2.89 ENST00000607131.5
dual specificity phosphatase 13
chrX_-_139642835 2.84 ENST00000536274.5
MCF.2 cell line derived transforming sequence
chr17_-_19748341 2.79 ENST00000395555.7
aldehyde dehydrogenase 3 family member A1
chr1_+_16921923 2.79 ENST00000375541.10
ciliary rootlet coiled-coil, rootletin
chr8_-_86743626 2.76 ENST00000320005.6
cyclic nucleotide gated channel subunit beta 3
chr16_+_81238682 2.72 ENST00000258168.7
ENST00000564552.1
beta-carotene oxygenase 1
chr2_-_29921580 2.69 ENST00000389048.8
ALK receptor tyrosine kinase
chr12_-_96400067 2.69 ENST00000542666.5
cyclin dependent kinase 17
chr9_-_42129125 2.67 ENST00000617422.4
ENST00000612828.4
ENST00000341990.8
ENST00000377561.7
ENST00000276974.7
contactin associated protein family member 3B
chrX_+_136196750 2.64 ENST00000539015.5
four and a half LIM domains 1
chr16_-_57971086 2.62 ENST00000564448.5
ENST00000311183.8
cyclic nucleotide gated channel subunit beta 1
chr17_-_19748285 2.57 ENST00000570414.1
ENST00000225740.11
aldehyde dehydrogenase 3 family member A1
chr6_+_31620701 2.50 ENST00000376033.3
ENST00000376007.8
proline rich coiled-coil 2A
chr11_-_128842467 2.48 ENST00000392664.2
potassium inwardly rectifying channel subfamily J member 1
chr22_-_29267965 2.41 ENST00000216085.12
rhomboid domain containing 3
chrX_+_136197039 2.40 ENST00000370683.6
four and a half LIM domains 1
chrX_-_139642889 2.39 ENST00000370576.9
MCF.2 cell line derived transforming sequence
chr17_-_19748355 2.37 ENST00000494157.6
aldehyde dehydrogenase 3 family member A1
chr1_+_197268222 2.35 ENST00000367400.8
ENST00000638467.1
ENST00000367399.6
crumbs cell polarity complex component 1
chr12_-_13095664 2.30 ENST00000337630.10
ENST00000545699.1
germ cell associated 1
chr17_+_70104848 2.22 ENST00000392670.5
potassium inwardly rectifying channel subfamily J member 16
chr13_+_113667213 2.22 ENST00000335678.7
G protein-coupled receptor kinase 1
chr17_-_35560812 2.20 ENST00000674182.1
schlafen family member 14
chr12_+_80707625 2.12 ENST00000228641.4
myogenic factor 6
chr15_+_64151706 2.10 ENST00000325881.9
sorting nexin 22
chr11_-_62984690 2.10 ENST00000421062.2
ENST00000458333.6
solute carrier family 22 member 6
chr18_-_26863187 2.09 ENST00000440832.7
aquaporin 4
chr22_+_29268316 2.01 ENST00000414183.6
ENST00000333395.10
ENST00000455726.5
ENST00000332035.10
EWS RNA binding protein 1
chr3_+_1092654 1.99 ENST00000350110.2
contactin 6
chr14_+_21317535 1.97 ENST00000382933.8
RPGR interacting protein 1
chr15_-_43266857 1.88 ENST00000349114.8
ENST00000220420.10
transglutaminase 5
chr1_+_160343375 1.79 ENST00000294785.10
ENST00000421914.5
ENST00000438008.5
nicastrin
chr17_+_79024243 1.74 ENST00000311661.4
C1q and TNF related 1
chr13_+_35476740 1.72 ENST00000537702.5
neurobeachin
chr1_+_113905290 1.69 ENST00000650450.2
DNA cross-link repair 1B
chr3_+_1093002 1.68 ENST00000446702.7
contactin 6
chr19_-_38849923 1.67 ENST00000601813.1
ENST00000221419.10
heterogeneous nuclear ribonucleoprotein L
chr19_-_49057730 1.65 ENST00000684222.1
ENST00000596965.5
chorionic gonadotropin subunit beta 7
chr17_+_79024142 1.62 ENST00000579760.6
ENST00000339142.6
C1q and TNF related 1
chr12_-_113136224 1.60 ENST00000546530.5
ENST00000261729.9
RAS protein activator like 1
chr10_-_84241538 1.59 ENST00000372105.4
leucine rich repeat, Ig-like and transmembrane domains 1
chr1_+_18630839 1.57 ENST00000420770.7
paired box 7
chr15_+_33310946 1.56 ENST00000415757.7
ENST00000634891.2
ENST00000389232.9
ENST00000622037.1
ryanodine receptor 3
chr16_-_57971121 1.56 ENST00000251102.13
cyclic nucleotide gated channel subunit beta 1
chr19_+_3708378 1.55 ENST00000541714.7
ENST00000539908.6
tight junction protein 3
chr1_+_18631006 1.55 ENST00000375375.7
paired box 7
chr15_-_31161157 1.52 ENST00000542188.5
transient receptor potential cation channel subfamily M member 1
chr12_-_13095628 1.50 ENST00000457134.6
ENST00000537302.5
germ cell associated 1
chr12_-_13095798 1.42 ENST00000396302.7
germ cell associated 1
chr6_-_41163103 1.40 ENST00000373122.8
ENST00000373113.8
triggering receptor expressed on myeloid cells 2
chr1_+_202462730 1.39 ENST00000290419.9
ENST00000491336.5
protein phosphatase 1 regulatory subunit 12B
chrX_+_15749848 1.39 ENST00000479740.5
ENST00000454127.2
carbonic anhydrase 5B
chr14_-_24081928 1.37 ENST00000396995.1
neural retina leucine zipper
chr5_-_33984681 1.37 ENST00000296589.9
solute carrier family 45 member 2
chr6_-_70283105 1.34 ENST00000683980.1
collagen type IX alpha 1 chain
chr12_-_76878985 1.30 ENST00000547435.1
ENST00000552330.5
ENST00000311083.10
ENST00000546966.5
cysteine and glycine rich protein 2
chrX_-_10620534 1.30 ENST00000317552.9
midline 1
chr4_-_75902444 1.30 ENST00000286719.12
protein phosphatase with EF-hand domain 2
chr14_+_58427686 1.28 ENST00000650904.1
ENST00000652326.2
ENST00000554463.5
ENST00000555833.5
KIAA0586
chrX_-_24647300 1.24 ENST00000379144.7
phosphate cytidylyltransferase 1, choline, beta
chr1_-_21279520 1.21 ENST00000357071.8
endothelin converting enzyme 1
chr6_-_70283184 1.18 ENST00000320755.12
collagen type IX alpha 1 chain
chr7_-_138798188 1.15 ENST00000310018.7
ATPase H+ transporting V0 subunit a4
chr14_-_24081986 1.14 ENST00000560550.1
neural retina leucine zipper
chr22_-_30471986 1.12 ENST00000401751.5
ENST00000402286.5
ENST00000403066.5
ENST00000215812.9
SEC14 like lipid binding 3
chr12_+_53425070 1.10 ENST00000550839.1
anti-Mullerian hormone receptor type 2
chr8_+_69466617 1.10 ENST00000525061.5
ENST00000260128.8
ENST00000458141.6
sulfatase 1
chr4_-_101347492 1.10 ENST00000394854.8
protein phosphatase 3 catalytic subunit alpha
chr3_-_14178569 1.09 ENST00000285021.12
XPC complex subunit, DNA damage recognition and repair factor
chrX_-_10620419 1.05 ENST00000380782.6
midline 1
chr11_-_126062782 1.01 ENST00000531738.6
cell adhesion associated, oncogene regulated
chr6_-_70283214 0.95 ENST00000683758.1
collagen type IX alpha 1 chain
chr17_+_17042433 0.95 ENST00000651222.2
myosin phosphatase Rho interacting protein
chr10_+_116590956 0.94 ENST00000358834.9
ENST00000528052.5
pancreatic lipase related protein 1
chr7_+_21428023 0.92 ENST00000432066.2
ENST00000222584.8
Sp4 transcription factor
chr7_-_138798104 0.90 ENST00000353492.4
ATPase H+ transporting V0 subunit a4
chr1_-_27604176 0.84 ENST00000642416.1
AT-hook DNA binding motif containing 1
chr6_-_35512882 0.82 ENST00000229771.11
TUB like protein 1
chr2_+_127418420 0.77 ENST00000234071.8
ENST00000429925.5
ENST00000442644.5
protein C, inactivator of coagulation factors Va and VIIIa
chrX_+_66162663 0.72 ENST00000519389.6
hephaestin
chr4_+_169620527 0.71 ENST00000360642.7
ENST00000512813.5
ENST00000513761.6
chloride voltage-gated channel 3
chrX_+_41447322 0.70 ENST00000378220.2
ENST00000342595.2
nyctalopin
chr5_+_141213919 0.69 ENST00000341948.6
protocadherin beta 13
chr1_-_27604135 0.67 ENST00000673934.1
ENST00000642245.1
AT-hook DNA binding motif containing 1
chrY_+_14522573 0.66 ENST00000643089.1
ENST00000382872.5
neuroligin 4 Y-linked
chr18_+_34710249 0.66 ENST00000680346.1
ENST00000348997.9
ENST00000681274.1
ENST00000680822.1
ENST00000680767.2
ENST00000597599.5
ENST00000444659.6
dystrobrevin alpha
chr4_+_169620509 0.62 ENST00000347613.8
chloride voltage-gated channel 3
chr19_-_51034993 0.54 ENST00000684732.1
kallikrein related peptidase 12
chr5_+_150508110 0.53 ENST00000261797.7
N-deacetylase and N-sulfotransferase 1
chr22_-_40533808 0.44 ENST00000422851.1
ENST00000651694.1
ENST00000652095.2
myocardin related transcription factor A
chr3_-_54928044 0.42 ENST00000273286.6
leucine rich repeats and transmembrane domains 1
chr1_-_165445220 0.40 ENST00000619224.1
retinoid X receptor gamma
chr1_-_47190013 0.36 ENST00000294338.7
PDZK1 interacting protein 1
chr5_+_134115563 0.34 ENST00000517851.5
ENST00000521639.5
ENST00000522375.5
ENST00000378560.8
ENST00000520958.5
ENST00000518915.5
ENST00000395023.5
transcription factor 7
chr4_+_125314918 0.33 ENST00000674496.2
ENST00000394329.9
FAT atypical cadherin 4
chr6_-_42722590 0.33 ENST00000230381.7
peripherin 2
chr1_-_165445088 0.32 ENST00000359842.10
retinoid X receptor gamma
chr17_+_40309161 0.30 ENST00000254066.10
retinoic acid receptor alpha
chr13_-_35476682 0.26 ENST00000379919.6
mab-21 like 1
chr19_+_47821907 0.24 ENST00000539067.5
ENST00000221996.12
ENST00000613299.1
cone-rod homeobox
chr5_+_42548043 0.24 ENST00000618088.4
ENST00000612382.4
growth hormone receptor
chr15_+_33310993 0.23 ENST00000634418.1
ENST00000634750.1
ryanodine receptor 3
chr1_+_171257930 0.18 ENST00000354841.4
flavin containing dimethylaniline monoxygenase 1
chr22_-_19150292 0.16 ENST00000086933.3
goosecoid homeobox 2
chr11_-_65857763 0.14 ENST00000531407.5
cofilin 1
chr6_-_35512863 0.14 ENST00000428978.1
ENST00000614066.4
ENST00000322263.8
TUB like protein 1
chr1_+_113979391 0.10 ENST00000393300.6
ENST00000369551.5
olfactomedin like 3
chr18_+_8717371 0.09 ENST00000359865.7
microtubule crosslinking factor 1
chr11_+_124865425 0.04 ENST00000397801.6
roundabout guidance receptor 3
chr15_+_48206286 0.03 ENST00000396577.7
ENST00000380993.8
solute carrier family 12 member 1
chr1_+_113979460 0.03 ENST00000320334.5
olfactomedin like 3
chr1_-_160343235 0.00 ENST00000368069.7
ENST00000241704.8
ENST00000647683.1
ENST00000649787.1
COPI coat complex subunit alpha
chr6_-_41163182 0.00 ENST00000338469.3
triggering receptor expressed on myeloid cells 2

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 8.9 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
2.0 5.9 GO:0008078 mesodermal cell migration(GO:0008078) axial mesoderm morphogenesis(GO:0048319)
1.8 31.4 GO:0007021 tubulin complex assembly(GO:0007021)
1.5 53.8 GO:0008045 motor neuron axon guidance(GO:0008045)
1.4 6.9 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
1.4 5.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
1.3 5.1 GO:0031627 telomeric loop formation(GO:0031627)
1.2 5.9 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
1.0 3.1 GO:0014813 skeletal muscle satellite cell commitment(GO:0014813)
1.0 8.8 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.9 8.3 GO:0032790 ribosome disassembly(GO:0032790)
0.9 8.8 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.9 8.7 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.8 4.2 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.8 6.1 GO:0006452 translational frameshifting(GO:0006452) positive regulation of translational termination(GO:0045905)
0.7 2.7 GO:0036269 swimming behavior(GO:0036269)
0.7 3.4 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.6 3.7 GO:2000291 regulation of myoblast proliferation(GO:2000291)
0.6 3.5 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.6 9.5 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.5 2.5 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.5 4.0 GO:0071286 cellular response to magnesium ion(GO:0071286)
0.5 13.5 GO:0071420 cellular response to histamine(GO:0071420)
0.5 3.5 GO:0006701 progesterone biosynthetic process(GO:0006701)
0.5 9.5 GO:0050962 detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.5 8.5 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.5 1.4 GO:0002585 positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002582) positive regulation of antigen processing and presentation of peptide antigen(GO:0002585) positive regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002588)
0.4 3.3 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.4 2.4 GO:0032815 negative regulation of natural killer cell activation(GO:0032815)
0.4 5.6 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.3 8.1 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.3 1.3 GO:0048388 endosomal lumen acidification(GO:0048388)
0.3 4.1 GO:0048263 determination of dorsal identity(GO:0048263)
0.3 7.8 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 1.0 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.3 0.8 GO:0044537 regulation of circulating fibrinogen levels(GO:0044537)
0.3 8.4 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.3 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.2 2.7 GO:0006776 vitamin A metabolic process(GO:0006776)
0.2 3.4 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.2 1.2 GO:0010814 substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959)
0.2 1.1 GO:1902612 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.2 5.9 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.2 2.4 GO:0035372 protein localization to microtubule(GO:0035372)
0.2 3.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.2 2.1 GO:0048743 positive regulation of skeletal muscle fiber development(GO:0048743)
0.2 5.2 GO:0042462 eye photoreceptor cell development(GO:0042462)
0.2 4.6 GO:0060445 branching involved in salivary gland morphogenesis(GO:0060445)
0.2 4.6 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.2 2.1 GO:0070070 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.2 1.1 GO:0060686 negative regulation of prostatic bud formation(GO:0060686)
0.2 18.9 GO:0005977 glycogen metabolic process(GO:0005977)
0.1 4.8 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.1 10.7 GO:0003254 regulation of membrane depolarization(GO:0003254)
0.1 1.8 GO:0007220 Notch receptor processing(GO:0007220)
0.1 4.2 GO:0097352 autophagosome maturation(GO:0097352)
0.1 3.1 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.1 1.0 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 4.2 GO:0060292 long term synaptic depression(GO:0060292)
0.1 3.7 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.1 3.7 GO:0050832 defense response to fungus(GO:0050832)
0.1 0.3 GO:0044336 canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.1 25.0 GO:0043523 regulation of neuron apoptotic process(GO:0043523)
0.1 0.3 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.1 0.2 GO:0046532 regulation of photoreceptor cell differentiation(GO:0046532)
0.1 13.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.3 GO:0060010 Sertoli cell fate commitment(GO:0060010)
0.1 3.2 GO:0010107 potassium ion import(GO:0010107)
0.1 1.1 GO:0031573 intra-S DNA damage checkpoint(GO:0031573)
0.1 1.6 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 0.5 GO:0015014 protein sulfation(GO:0006477) heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 5.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 8.2 GO:1903779 regulation of cardiac conduction(GO:1903779)
0.1 10.8 GO:0007601 visual perception(GO:0007601)
0.1 7.9 GO:0006805 xenobiotic metabolic process(GO:0006805)
0.0 2.1 GO:0003091 renal water homeostasis(GO:0003091)
0.0 1.9 GO:0018149 peptide cross-linking(GO:0018149)
0.0 3.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 19.6 GO:0048232 spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.0 0.2 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 1.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 4.9 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.7 GO:0006825 copper ion transport(GO:0006825)
0.0 1.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 1.7 GO:0007292 female gamete generation(GO:0007292)
0.0 0.7 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 1.3 GO:0007224 smoothened signaling pathway(GO:0007224)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 31.4 GO:0097512 cardiac myofibril(GO:0097512)
1.4 4.2 GO:0017071 intracellular cyclic nucleotide activated cation channel complex(GO:0017071)
1.3 5.3 GO:0035841 new growing cell tip(GO:0035841)
0.6 3.5 GO:0005594 collagen type IX trimer(GO:0005594)
0.4 9.2 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.3 13.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.3 1.1 GO:0071942 XPC complex(GO:0071942)
0.3 4.2 GO:0005883 neurofilament(GO:0005883)
0.3 1.8 GO:0070765 gamma-secretase complex(GO:0070765)
0.3 9.2 GO:0000421 autophagosome membrane(GO:0000421)
0.2 1.2 GO:0031302 intrinsic component of endosome membrane(GO:0031302)
0.2 2.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.2 8.1 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.2 2.8 GO:0035253 ciliary rootlet(GO:0035253)
0.1 4.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 7.8 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 8.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 1.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.0 GO:0005955 calcineurin complex(GO:0005955)
0.1 5.5 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 4.6 GO:0043198 dendritic shaft(GO:0043198)
0.1 0.2 GO:0070195 growth hormone receptor complex(GO:0070195)
0.1 6.9 GO:0043195 terminal bouton(GO:0043195)
0.1 9.3 GO:0005901 caveola(GO:0005901)
0.1 3.1 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 2.0 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 1.8 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 5.0 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.1 6.3 GO:0005814 centriole(GO:0005814)
0.1 6.1 GO:0005643 nuclear pore(GO:0005643)
0.0 3.4 GO:0005581 collagen trimer(GO:0005581)
0.0 2.3 GO:0005902 microvillus(GO:0005902)
0.0 4.3 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.8 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 2.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 5.1 GO:0032587 ruffle membrane(GO:0032587)
0.0 5.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 4.2 GO:0043197 dendritic spine(GO:0043197)
0.0 4.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 6.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.4 GO:0031672 A band(GO:0031672)
0.0 3.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 3.4 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 12.5 GO:0005925 focal adhesion(GO:0005925)
0.0 6.3 GO:0009986 cell surface(GO:0009986)
0.0 26.8 GO:0005615 extracellular space(GO:0005615)
0.0 19.1 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 38.8 GO:0016021 integral component of membrane(GO:0016021)
0.0 0.3 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 2.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 18.9 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.3 39.8 GO:0005212 structural constituent of eye lens(GO:0005212)
1.3 7.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
1.2 3.5 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
1.2 6.9 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
1.1 53.8 GO:0046875 ephrin receptor binding(GO:0046875)
1.1 9.8 GO:0099529 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.9 8.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.8 8.5 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.7 14.0 GO:0031404 chloride ion binding(GO:0031404)
0.7 2.2 GO:0050254 rhodopsin kinase activity(GO:0050254)
0.7 3.4 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.6 4.4 GO:0001640 adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988)
0.6 4.2 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.6 5.1 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.5 8.3 GO:0043024 ribosomal small subunit binding(GO:0043024)
0.5 24.6 GO:0030552 cAMP binding(GO:0030552)
0.4 2.7 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.4 5.5 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.4 3.7 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.4 3.5 GO:0030020 extracellular matrix structural constituent conferring tensile strength(GO:0030020)
0.4 1.1 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.4 1.8 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.3 1.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.3 5.3 GO:0005402 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.3 8.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 3.3 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.3 2.5 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.3 1.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.3 8.9 GO:0036041 long-chain fatty acid binding(GO:0036041)
0.3 9.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.3 1.9 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 7.8 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 6.1 GO:0003746 translation elongation factor activity(GO:0003746)
0.2 1.4 GO:0070891 lipoteichoic acid binding(GO:0070891)
0.2 1.0 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.2 1.1 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.2 0.7 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 3.7 GO:0005112 Notch binding(GO:0005112)
0.2 2.8 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 4.8 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 1.7 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.1 3.1 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.1 0.5 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.1 4.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.1 2.2 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 6.1 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 5.6 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 1.0 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 9.4 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 4.1 GO:0005109 frizzled binding(GO:0005109)
0.1 6.0 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 0.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 2.7 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 2.1 GO:0046961 ATPase activity, coupled to transmembrane movement of ions, rotational mechanism(GO:0044769) proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.4 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 3.1 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 4.2 GO:0070063 RNA polymerase binding(GO:0070063)
0.1 5.5 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 23.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 9.2 GO:0044325 ion channel binding(GO:0044325)
0.0 2.8 GO:0019894 kinesin binding(GO:0019894)
0.0 0.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.3 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.0 0.9 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 4.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 2.3 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)
0.0 5.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 1.7 GO:0043022 ribosome binding(GO:0043022)
0.0 2.1 GO:0070888 E-box binding(GO:0070888)
0.0 4.3 GO:0005179 hormone activity(GO:0005179)
0.0 1.5 GO:0017046 peptide hormone binding(GO:0017046)
0.0 2.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 3.4 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 17.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 8.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 1.1 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.0 GO:0008511 sodium:potassium:chloride symporter activity(GO:0008511)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 58.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 8.3 PID RHODOPSIN PATHWAY Visual signal transduction: Rods
0.2 9.9 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 8.1 PID ATR PATHWAY ATR signaling pathway
0.1 3.5 NABA COLLAGENS Genes encoding collagen proteins
0.1 1.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 1.1 PID ALK2 PATHWAY ALK2 signaling events
0.0 3.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.6 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 3.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.8 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 3.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.6 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.6 8.9 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.4 13.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.3 58.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.3 8.3 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.3 3.3 REACTOME OPSINS Genes involved in Opsins
0.3 3.5 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.2 4.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 4.6 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2 6.9 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 8.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 1.8 REACTOME SIGNALING BY NOTCH3 Genes involved in Signaling by NOTCH3
0.1 3.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1 4.6 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.1 2.1 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.1 9.9 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 4.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 3.9 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 1.4 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.1 2.1 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 1.4 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 3.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 3.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 5.5 REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0 1.0 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.1 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.7 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.0 5.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 1.0 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 2.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.2 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis