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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GUAACAG
Z-value: 0.40
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miRNA associated with seed GUAACAG
| Name | miRBASE accession |
|---|---|
|
hsa-miR-194-5p
|
MIMAT0000460 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GUAACAG
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_-_149971109 Show fit | 6.43 |
ENST00000239940.11
|
profilin 2 |
|
| chr17_-_64662290 Show fit | 5.85 |
ENST00000262435.14
|
SMAD specific E3 ubiquitin protein ligase 2 |
|
| chr20_-_45348414 Show fit | 5.22 |
ENST00000372733.3
|
syndecan 4 |
|
| chr1_-_225653045 Show fit | 4.81 |
ENST00000366843.6
ENST00000366844.7 |
ENAH actin regulator |
|
| chrX_+_120604084 Show fit | 4.15 |
ENST00000371317.10
|
MCTS1 re-initiation and release factor |
|
| chr14_+_61695777 Show fit | 4.07 |
ENST00000323441.10
|
hypoxia inducible factor 1 subunit alpha |
|
| chr11_-_115504389 Show fit | 3.91 |
ENST00000545380.5
ENST00000452722.7 ENST00000331581.11 ENST00000537058.5 ENST00000536727.5 ENST00000542447.6 |
cell adhesion molecule 1 |
|
| chr9_+_128683645 Show fit | 3.77 |
ENST00000372692.8
|
SET nuclear proto-oncogene |
|
| chr11_+_74949241 Show fit | 3.76 |
ENST00000610881.4
ENST00000530257.5 ENST00000526361.1 ENST00000532972.5 ENST00000263672.11 |
signal peptidase complex subunit 2 |
|
| chr17_-_59707404 Show fit | 3.76 |
ENST00000393038.3
|
peptidyl-tRNA hydrolase 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.4 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 1.5 | 6.2 | GO:0048205 | COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 1.5 | 5.8 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 0.8 | 5.5 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.9 | 5.2 | GO:1903553 | positive regulation of extracellular exosome assembly(GO:1903553) |
| 1.0 | 4.2 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.6 | 3.9 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.5 | 3.8 | GO:2000210 | positive regulation of anoikis(GO:2000210) |
| 0.1 | 3.8 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.1 | 3.8 | GO:0006337 | nucleosome disassembly(GO:0006337) negative regulation of histone acetylation(GO:0035067) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.5 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 6.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 5.2 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 4.8 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 4.2 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 4.2 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.1 | 4.1 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.0 | 3.9 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.4 | 3.8 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.0 | 3.6 | GO:0005811 | lipid particle(GO:0005811) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.4 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 5.8 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.4 | 5.2 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.1 | 5.0 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 4.7 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 4.3 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 4.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.8 | 3.8 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.1 | 3.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 3.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 6.9 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 6.3 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 5.0 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 4.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.1 | 4.8 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 4.4 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 4.4 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.6 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.0 | 7.6 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 5.8 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 5.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.2 | 5.2 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.1 | 4.9 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.2 | 3.8 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |
| 0.0 | 3.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 3.2 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 3.2 | REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION | Genes involved in Amino acid synthesis and interconversion (transamination) |