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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GUAGUGU
Z-value: 0.73
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miRNA associated with seed GUAGUGU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-142-3p.1
|
MIMAT0000434 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GUAGUGU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.0 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 4.7 | 14.2 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 1.6 | 9.8 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 1.3 | 8.8 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 2.2 | 8.7 | GO:0030047 | actin modification(GO:0030047) |
| 0.8 | 8.2 | GO:0032510 | endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510) |
| 0.1 | 8.2 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 8.1 | GO:0006457 | protein folding(GO:0006457) |
| 2.6 | 7.9 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.2 | 7.1 | GO:0060612 | adipose tissue development(GO:0060612) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 3.8 | 11.3 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.2 | 11.1 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 11.1 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 9.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.6 | 8.2 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 1.1 | 7.9 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 7.8 | GO:0030175 | filopodium(GO:0030175) |
| 1.5 | 7.6 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.1 | 7.6 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 14.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 2.8 | 11.3 | GO:1990430 | extracellular matrix protein binding(GO:1990430) |
| 2.6 | 10.4 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.2 | 8.6 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.5 | 8.2 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
| 0.2 | 8.0 | GO:0003785 | actin monomer binding(GO:0003785) |
| 1.6 | 7.9 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.3 | 7.6 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 7.1 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 19.2 | PID S1P S1P1 PATHWAY | S1P1 pathway |
| 0.3 | 15.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 11.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 9.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.1 | 8.7 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 6.1 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.2 | 5.3 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 4.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 4.5 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.1 | 3.7 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.3 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.8 | 14.2 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.3 | 13.8 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 10.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 6.3 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.6 | 5.1 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 4.9 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 4.6 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |
| 0.2 | 3.2 | REACTOME MTORC1 MEDIATED SIGNALLING | Genes involved in mTORC1-mediated signalling |
| 0.0 | 3.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |