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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GUCAGUU
Z-value: 0.40
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miRNA associated with seed GUCAGUU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-223-3p
|
MIMAT0000280 |
Network of associatons between targets according to the STRING database.
First level regulatory network of GUCAGUU
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 6.0 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.3 | 5.1 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.2 | 3.5 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.2 | 3.5 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.3 | 3.4 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 0.2 | 3.4 | GO:0051256 | mitotic spindle midzone assembly(GO:0051256) |
| 0.8 | 3.1 | GO:2001247 | positive regulation of phosphatidylcholine biosynthetic process(GO:2001247) |
| 0.2 | 3.0 | GO:0036500 | ATF6-mediated unfolded protein response(GO:0036500) |
| 0.0 | 3.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 2.8 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 6.0 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 5.6 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 5.3 | GO:0000785 | chromatin(GO:0000785) |
| 1.0 | 5.1 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.1 | 5.0 | GO:0045171 | intercellular bridge(GO:0045171) |
| 0.0 | 3.4 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 3.1 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 3.1 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.2 | 3.0 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.0 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 4.8 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 3.7 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 3.5 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.1 | 3.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 0.3 | 3.3 | GO:0001135 | transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135) |
| 0.1 | 3.1 | GO:0102391 | decanoate--CoA ligase activity(GO:0102391) |
| 0.1 | 3.0 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 2.9 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 2.8 | GO:0046790 | virion binding(GO:0046790) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.1 | 3.2 | PID SYNDECAN 2 PATHWAY | Syndecan-2-mediated signaling events |
| 0.0 | 2.9 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 2.7 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 2.5 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.0 | 2.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.4 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.0 | 0.9 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.6 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 3.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 3.4 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 3.1 | REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS | Genes involved in Synthesis of very long-chain fatty acyl-CoAs |
| 0.2 | 3.0 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.0 | 2.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.0 | 2.6 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.1 | 2.4 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.1 | 2.2 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 2.0 | REACTOME RNA POL III CHAIN ELONGATION | Genes involved in RNA Polymerase III Chain Elongation |