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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for GUGCAAA
Z-value: 1.10
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miRNA associated with seed GUGCAAA
Network of associatons between targets according to the STRING database.
First level regulatory network of GUGCAAA
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_137499293 Show fit | 20.53 |
ENST00000510689.5
ENST00000394945.6 |
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 |
|
| chr15_-_73633310 Show fit | 18.44 |
ENST00000345330.9
|
neuroplastin |
|
| chr1_+_51236252 Show fit | 18.41 |
ENST00000242719.4
|
ring finger protein 11 |
|
| chr9_-_136050502 Show fit | 17.56 |
ENST00000371753.5
|
NACC family member 2 |
|
| chr14_-_59630582 Show fit | 16.52 |
ENST00000395090.5
|
reticulon 1 |
|
| chr6_+_121435595 Show fit | 16.30 |
ENST00000649003.1
ENST00000282561.4 |
gap junction protein alpha 1 |
|
| chr14_+_90397019 Show fit | 16.11 |
ENST00000447653.8
ENST00000356978.9 ENST00000626705.2 |
calmodulin 1 |
|
| chrX_+_135985416 Show fit | 15.15 |
ENST00000370698.7
ENST00000627534.2 ENST00000370695.8 ENST00000630721.3 ENST00000678163.1 |
solute carrier family 9 member A6 |
|
| chr12_+_78864768 Show fit | 14.10 |
ENST00000261205.9
ENST00000457153.6 |
synaptotagmin 1 |
|
| chr15_-_34101807 Show fit | 12.26 |
ENST00000527822.5
ENST00000528949.1 ENST00000256545.9 |
ER membrane protein complex subunit 7 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 28.8 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.3 | 24.4 | GO:0010812 | negative regulation of cell-substrate adhesion(GO:0010812) |
| 2.7 | 19.2 | GO:0048170 | positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 1.8 | 17.9 | GO:0031547 | brain-derived neurotrophic factor receptor signaling pathway(GO:0031547) |
| 2.5 | 17.6 | GO:1902231 | positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231) |
| 4.1 | 16.3 | GO:0010652 | regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) |
| 4.7 | 14.1 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 0.1 | 14.0 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.4 | 13.8 | GO:0018146 | keratan sulfate biosynthetic process(GO:0018146) |
| 0.1 | 13.3 | GO:1900006 | positive regulation of dendrite development(GO:1900006) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 31.4 | GO:0005819 | spindle(GO:0005819) |
| 1.9 | 24.1 | GO:0060077 | inhibitory synapse(GO:0060077) |
| 0.2 | 21.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 21.2 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.1 | 19.7 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.4 | 18.3 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.5 | 17.5 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.5 | 17.4 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
| 0.9 | 16.3 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 15.7 | GO:0005875 | microtubule associated complex(GO:0005875) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 34.0 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 29.6 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.9 | 20.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 3.7 | 18.4 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.3 | 17.0 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.3 | 16.9 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 2.7 | 16.3 | GO:0086075 | gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075) |
| 2.6 | 15.6 | GO:0034046 | poly(G) binding(GO:0034046) |
| 0.2 | 15.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 15.3 | GO:0003779 | actin binding(GO:0003779) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 20.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 17.0 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.3 | 16.7 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.3 | 16.3 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.3 | 14.4 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.3 | 13.0 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
| 0.3 | 13.0 | PID REELIN PATHWAY | Reelin signaling pathway |
| 0.2 | 11.3 | PID MET PATHWAY | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| 0.3 | 10.7 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.2 | 10.7 | PID BMP PATHWAY | BMP receptor signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 25.0 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.1 | 19.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.8 | 16.1 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.7 | 16.1 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.5 | 13.8 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.1 | 13.8 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.4 | 12.5 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.3 | 11.4 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.3 | 10.3 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.7 | 10.2 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |