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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HAND1
Z-value: 0.56
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Transcription factors associated with HAND1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HAND1 | hg38_v1_chr5_-_154478218_154478234 | 0.21 | 2.0e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HAND1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 9.0 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 0.4 | 8.3 | GO:0006068 | ethanol catabolic process(GO:0006068) |
| 0.1 | 7.4 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.1 | 6.9 | GO:0098869 | cellular oxidant detoxification(GO:0098869) |
| 0.0 | 5.0 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.6 | 4.8 | GO:0030450 | regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027) |
| 0.2 | 4.5 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 4.3 | GO:0007032 | endosome organization(GO:0007032) |
| 0.3 | 3.7 | GO:0016191 | synaptic vesicle uncoating(GO:0016191) |
| 1.2 | 3.6 | GO:0016487 | sesquiterpenoid metabolic process(GO:0006714) sesquiterpenoid catabolic process(GO:0016107) farnesol metabolic process(GO:0016487) farnesol catabolic process(GO:0016488) regulation of testosterone biosynthetic process(GO:2000224) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 7.5 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.9 | 6.8 | GO:0097442 | CA3 pyramidal cell dendrite(GO:0097442) |
| 0.0 | 5.6 | GO:0060076 | excitatory synapse(GO:0060076) |
| 0.0 | 5.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 5.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 4.8 | GO:0044215 | other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.3 | 4.5 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.1 | 3.5 | GO:0098636 | protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 2.4 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.4 | 2.2 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 9.0 | GO:0031696 | alpha-2C adrenergic receptor binding(GO:0031696) |
| 1.4 | 8.3 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.2 | 6.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.3 | 6.8 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 1.3 | 6.5 | GO:0047086 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.3 | 4.5 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.7 | 4.3 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.3 | 3.6 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.7 | 3.0 | GO:0004853 | uroporphyrinogen decarboxylase activity(GO:0004853) |
| 0.4 | 3.0 | GO:0003828 | alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 6.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.1 | 4.8 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.0 | 2.2 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.1 | 1.8 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.8 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 1.6 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 1.4 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 1.1 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 6.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.2 | 4.8 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 4.3 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 3.7 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.0 | 3.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 3.0 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 2.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.0 | 2.1 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.1 | 1.8 | REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS | Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus |