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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HDX
Z-value: 0.28
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Transcription factors associated with HDX
Network of associatons between targets according to the STRING database.
First level regulatory network of HDX
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.6 | 6.0 | GO:0032119 | sequestering of zinc ion(GO:0032119) |
| 0.1 | 6.0 | GO:0033198 | response to ATP(GO:0033198) |
| 0.1 | 4.4 | GO:0002228 | natural killer cell mediated immunity(GO:0002228) |
| 0.5 | 3.2 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.8 | 2.5 | GO:0060559 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) |
| 0.3 | 1.6 | GO:0038161 | prolactin signaling pathway(GO:0038161) |
| 0.1 | 1.6 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.3 | 1.4 | GO:1990164 | histone H2A phosphorylation(GO:1990164) |
| 0.0 | 1.1 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.4 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.2 | 8.0 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 6.0 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.2 | 3.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 1.6 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.0 | 1.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.9 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 0.4 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 2.0 | 6.0 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 1.2 | 6.0 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.9 | 4.4 | GO:0023024 | MHC class I protein complex binding(GO:0023024) |
| 0.2 | 3.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 2.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.4 | 1.6 | GO:0004925 | prolactin receptor activity(GO:0004925) |
| 0.0 | 1.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.2 | 1.4 | GO:0035184 | histone threonine kinase activity(GO:0035184) |
| 0.0 | 1.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.2 | 6.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.2 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 1.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 1.6 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.0 | 0.5 | ST TYPE I INTERFERON PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.1 | 3.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 2.5 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 1.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 0.9 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.0 | 0.9 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |
| 0.0 | 0.5 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.0 | 0.4 | REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN | Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin |