ISMARA results: HES1

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for HES1

Z-value: 1.26

Motif logo

Transcription factors associated with HES1

Gene Symbol	Gene ID	Gene Info
HES1 Ensembl NCBI GeneCards UniProt	ENSG00000114315.4	HES1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HES1	hg38_v1_chr3_+_194136138_194136155	-0.18	8.3e-03	Click!

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr6_-_13814490 Show fit	35.59	ENST00000379170.8	MCUR1 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial calcium uniporter regulator 1
chr9_+_89311187 Show fit	27.36	ENST00000314355.7	CKS2 Ensembl NCBI GeneCards UniProt Show fit	CDC28 protein kinase regulatory subunit 2
chr2_-_10448318 Show fit	26.54	ENST00000234111.9	ODC1 Ensembl NCBI GeneCards UniProt Show fit	ornithine decarboxylase 1
chr1_+_165827786 Show fit	22.41	ENST00000642653.1	UCK2 Ensembl NCBI GeneCards UniProt Show fit	uridine-cytidine kinase 2
chr1_+_165827574 Show fit	20.26	ENST00000367879.9	UCK2 Ensembl NCBI GeneCards UniProt Show fit	uridine-cytidine kinase 2
chrX_+_21940693 Show fit	18.67	ENST00000404933.7 ENST00000379404.5	SMS Ensembl NCBI GeneCards UniProt Show fit	spermine synthase
chr3_+_184363427 Show fit	18.46	ENST00000429568.1	POLR2H Ensembl NCBI GeneCards UniProt Show fit	RNA polymerase II, I and III subunit H
chr3_+_184363387 Show fit	18.37	ENST00000452961.5	POLR2H Ensembl NCBI GeneCards UniProt Show fit	RNA polymerase II, I and III subunit H
chr3_+_184363351 Show fit	17.10	ENST00000443489.5	POLR2H Ensembl NCBI GeneCards UniProt Show fit	RNA polymerase II, I and III subunit H
chr1_+_220094086 Show fit	17.02	ENST00000366922.3	IARS2 Ensembl NCBI GeneCards UniProt Show fit	isoleucyl-tRNA synthetase 2, mitochondrial

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.7	69.3	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
10.7	42.7	GO:0006238	CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
8.2	41.2	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
2.4	41.0	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
4.8	38.7	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
1.8	36.9	GO:0006206	pyrimidine nucleobase metabolic process(GO:0006206)
0.3	33.5	GO:0006414	translational elongation(GO:0006414)
0.9	26.0	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
1.1	25.6	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.8	24.5	GO:0006607	NLS-bearing protein import into nucleus(GO:0006607)

Showing 1 to 10 of 295 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	84.1	GO:1904813	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
4.0	64.4	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.1	51.8	GO:0016607	nuclear speck(GO:0016607)
0.9	51.2	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.1	43.1	GO:0005743	mitochondrial inner membrane(GO:0005743)
1.3	38.7	GO:0031304	intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
3.3	36.8	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
1.2	34.8	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2	34.4	GO:0005681	spliceosomal complex(GO:0005681)
0.6	32.0	GO:0042645	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)

Showing 1 to 10 of 143 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
4.0	64.4	GO:0001054	RNA polymerase I activity(GO:0001054)
0.7	47.0	GO:0003743	translation initiation factor activity(GO:0003743)
6.1	42.7	GO:0004849	uridine kinase activity(GO:0004849)
6.8	41.0	GO:0061575	cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
3.4	36.9	GO:0004645	phosphorylase activity(GO:0004645)
0.8	35.4	GO:0008139	nuclear localization sequence binding(GO:0008139)
2.7	35.2	GO:0097100	supercoiled DNA binding(GO:0097100)
0.2	35.2	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.7	34.0	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
6.3	31.7	GO:0047280	nicotinamide phosphoribosyltransferase activity(GO:0047280)

Showing 1 to 10 of 214 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	95.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.0	36.0	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.7	29.5	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.4	29.1	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.3	18.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.4	17.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.4	16.1	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.4	15.3	PID ATR PATHWAY	ATR signaling pathway
0.4	14.8	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.3	14.3	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5

Showing 1 to 10 of 47 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	92.3	REACTOME TRANSLATION	Genes involved in Translation
3.1	64.4	REACTOME RNA POL III CHAIN ELONGATION	Genes involved in RNA Polymerase III Chain Elongation
3.2	63.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
1.5	58.3	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.4	49.5	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.5	47.9	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes
3.4	37.7	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.5	30.5	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.2	28.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5	27.3	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane

Showing 1 to 10 of 87 entries

Results for HES1

Z-value: 1.26

Motif logo

Transcription factors associated with HES1

Activity-expression correlation:

Activity profile of HES1 motif

Sorted Z-values of HES1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HES1

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: