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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HES7_HES5

Z-value: 0.79

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Transcription factors associated with HES7_HES5

Gene Symbol Gene ID Gene Info
ENSG00000179111.9 HES7
ENSG00000197921.6 HES5

Activity profile of HES7_HES5 motif

Sorted Z-values of HES7_HES5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HES7_HES5

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr1_-_25906931 32.88 ENST00000357865.6
stathmin 1
chr1_-_25906411 16.66 ENST00000455785.7
stathmin 1
chr1_-_25905989 14.94 ENST00000399728.5
stathmin 1
chr1_-_25906457 14.00 ENST00000426559.6
stathmin 1
chr4_-_144019287 9.97 ENST00000638448.1
ENST00000513128.5
ENST00000506516.6
ENST00000429670.3
ENST00000502664.6
glycophorin B (MNS blood group)
chr4_-_144140683 9.41 ENST00000324022.14
glycophorin A (MNS blood group)
chr4_-_144140635 9.18 ENST00000512064.5
ENST00000512789.5
ENST00000504786.5
ENST00000503627.2
ENST00000642713.1
ENST00000643148.1
ENST00000642738.1
ENST00000642295.1
ENST00000646447.1
ENST00000535709.6
glycophorin A (MNS blood group)
chr19_+_4304632 8.66 ENST00000597590.5
fibronectin type III and SPRY domain containing 1
chr2_-_2326210 7.81 ENST00000647755.1
myelin transcription factor 1 like
chr4_-_144140725 7.16 ENST00000360771.8
glycophorin A (MNS blood group)
chr19_+_4304588 7.16 ENST00000221856.11
fibronectin type III and SPRY domain containing 1
chr4_-_144140712 7.13 ENST00000641688.3
glycophorin A (MNS blood group)
chr11_+_125904467 6.90 ENST00000263576.11
ENST00000530414.5
ENST00000530129.6
DEAD-box helicase 25
chr1_+_15756659 6.54 ENST00000375771.5
filamin binding LIM protein 1
chr2_-_2326378 6.42 ENST00000647618.1
myelin transcription factor 1 like
chr19_-_3700390 6.28 ENST00000679885.1
ENST00000537021.1
ENST00000589578.5
ENST00000539785.5
ENST00000335312.8
phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
chr16_-_21837770 6.17 ENST00000537951.1
nuclear pore complex interacting protein family member B4
chr16_-_21405319 5.85 ENST00000542817.1
nuclear pore complex interacting protein family member B3
chr16_+_22533600 5.68 ENST00000357370.6
nuclear pore complex interacting protein family member B5
chr9_+_68705414 5.51 ENST00000541509.5
phosphatidylinositol-4-phosphate 5-kinase type 1 beta
chr13_+_34942263 5.50 ENST00000379939.7
ENST00000400445.7
neurobeachin
chr16_-_30225829 5.48 ENST00000543463.1
nuclear pore complex interacting protein family, member B13
chr16_-_29485859 5.32 ENST00000458643.3
nuclear pore complex interacting protein family member B12
chr5_+_153490655 5.13 ENST00000518142.5
ENST00000285900.10
glutamate ionotropic receptor AMPA type subunit 1
chr4_-_143905529 4.89 ENST00000358615.9
ENST00000437468.2
glycophorin E (MNS blood group)
chr4_+_127965429 4.71 ENST00000513371.1
ENST00000611882.1
abhydrolase domain containing 18
chr19_+_57584131 4.70 ENST00000536878.6
ENST00000597219.1
ENST00000598689.1
ENST00000597850.2
zinc finger protein interacting with K protein 1
chr11_+_35618450 4.64 ENST00000317811.6
four-jointed box kinase 1
chr3_-_183825513 4.55 ENST00000318631.8
ENST00000431348.1
MAP6 domain containing 1
chr8_+_6708626 4.55 ENST00000285518.11
1-acylglycerol-3-phosphate O-acyltransferase 5
chr14_-_77271200 4.42 ENST00000298352.5
neuroglobin
chr4_-_170003738 4.11 ENST00000502832.1
ENST00000393704.3
microfibril associated protein 3 like
chr22_-_50085331 3.98 ENST00000395876.6
modulator of VRAC current 1
chr22_-_50085414 3.89 ENST00000311597.10
modulator of VRAC current 1
chr15_+_68578970 3.86 ENST00000261861.10
coronin 2B
chr11_+_35662739 3.70 ENST00000299413.7
tripartite motif containing 44
chr14_+_65412717 3.59 ENST00000673929.1
fucosyltransferase 8
chr22_+_30356974 3.43 ENST00000445005.5
ENST00000430839.5
ENST00000338306.8
coiled-coil domain containing 157
chr14_-_67359769 3.42 ENST00000555431.5
ENST00000554236.5
ENST00000555474.5
ENST00000216442.12
ATPase H+ transporting V1 subunit D
chr14_+_65412949 3.37 ENST00000674118.1
ENST00000553924.5
ENST00000358307.6
ENST00000557338.5
ENST00000554610.1
fucosyltransferase 8
chr6_-_73452253 3.32 ENST00000370318.5
ENST00000370315.4
cyclic GMP-AMP synthase
chr21_-_32612806 3.29 ENST00000673807.1
CFAP298-TCP10L readthrough
chr11_+_60429595 3.24 ENST00000528905.1
ENST00000528093.1
membrane spanning 4-domains A5
chr1_+_27935022 3.16 ENST00000411604.5
ENST00000373888.8
sphingomyelin phosphodiesterase acid like 3B
chr11_+_60429567 3.11 ENST00000300190.7
membrane spanning 4-domains A5
chr3_-_126101506 3.01 ENST00000509064.5
ENST00000508835.5
solute carrier family 41 member 3
chr1_-_6180265 2.97 ENST00000262450.8
chromodomain helicase DNA binding protein 5
chr4_-_18021727 2.79 ENST00000675605.1
ENST00000675927.1
ENST00000674942.1
ENST00000675143.1
ENST00000382226.5
ENST00000326877.8
ENST00000635767.1
ligand dependent nuclear receptor corepressor like
chr10_-_69409275 2.78 ENST00000373307.5
tachykinin receptor 2
chr17_-_7916280 2.64 ENST00000324348.9
ring finger protein 227
chr16_+_5071806 2.64 ENST00000684335.1
ENST00000684190.1
ENST00000586840.1
ENST00000262374.10
ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
chr3_-_9843942 2.55 ENST00000424438.5
ENST00000433555.1
ENST00000427174.5
ENST00000418713.5
ENST00000433535.6
ENST00000383820.9
ENST00000433972.1
RNA pseudouridine synthase D3
chr7_+_118214633 2.52 ENST00000477532.5
ankyrin repeat domain 7
chr20_-_47356670 2.50 ENST00000540497.5
ENST00000461685.5
ENST00000617418.4
ENST00000435836.5
ENST00000471951.6
ENST00000352431.6
ENST00000360911.7
ENST00000458360.6
zinc finger MYND-type containing 8
chrX_+_10158448 2.48 ENST00000380829.5
ENST00000421085.7
ENST00000674669.1
ENST00000454850.1
chloride voltage-gated channel 4
chr10_-_131982006 2.45 ENST00000368636.8
BCL2 interacting protein 3
chrX_+_134460138 2.42 ENST00000298556.8
hypoxanthine phosphoribosyltransferase 1
chr16_+_84175933 2.35 ENST00000569735.1
dynein axonemal assembly factor 1
chr3_+_48989876 2.34 ENST00000343546.8
prolyl 4-hydroxylase, transmembrane
chr11_-_46846233 2.28 ENST00000529230.6
ENST00000312055.9
cytoskeleton associated protein 5
chr10_+_48306698 2.28 ENST00000374179.8
mitogen-activated protein kinase 8
chr4_+_127965394 2.23 ENST00000645843.2
ENST00000388795.9
abhydrolase domain containing 18
chr1_+_28505943 2.22 ENST00000398958.6
ENST00000649185.1
ENST00000427469.5
ENST00000683442.1
ENST00000434290.6
ENST00000373833.10
ENST00000413987.1
regulator of chromosome condensation 1
small nucleolar RNA host gene 3
chr3_+_38496329 2.18 ENST00000287675.10
ENST00000630638.1
ENST00000422077.6
exo/endonuclease G
chr17_-_7915929 2.17 ENST00000635932.1
ENST00000640240.1
ring finger protein 227
chr7_-_1459461 2.12 ENST00000297508.8
MICAL like 2
chr2_+_64989343 2.10 ENST00000234256.4
solute carrier family 1 member 4
chr11_-_777467 2.05 ENST00000397472.6
ENST00000524550.5
ENST00000319863.13
ENST00000526325.5
glutamine amidotransferase like class 1 domain containing 1
chr22_+_30356620 2.03 ENST00000399824.6
ENST00000405659.5
coiled-coil domain containing 157
chr14_+_24171853 1.93 ENST00000620473.4
ENST00000557806.5
ENST00000611366.5
REC8 meiotic recombination protein
chr12_-_84912705 1.91 ENST00000679933.1
ENST00000680260.1
ENST00000551010.2
ENST00000679453.1
ENST00000681281.1
solute carrier family 6 member 15
chr10_+_91220603 1.79 ENST00000336126.6
polycomb group ring finger 5
chr20_-_47356721 1.76 ENST00000262975.8
ENST00000446994.6
ENST00000355972.8
ENST00000396281.8
ENST00000619049.4
ENST00000611941.4
ENST00000372023.7
zinc finger MYND-type containing 8
chr12_+_102957666 1.76 ENST00000266744.4
achaete-scute family bHLH transcription factor 1
chr19_+_840991 1.75 ENST00000234347.10
proteinase 3
chr10_+_48306639 1.75 ENST00000395611.7
ENST00000432379.5
ENST00000374189.5
mitogen-activated protein kinase 8
chr21_+_44353633 1.72 ENST00000397932.6
ENST00000300481.13
transient receptor potential cation channel subfamily M member 2
chr19_-_40404270 1.66 ENST00000673881.1
periaxin
chr5_+_149730260 1.56 ENST00000360453.8
ENST00000394320.7
ENST00000309241.10
PPARG coactivator 1 beta
chr14_+_65411845 1.54 ENST00000556518.5
ENST00000557164.5
fucosyltransferase 8
chr2_+_73984902 1.49 ENST00000409262.8
tet methylcytosine dioxygenase 3
chr6_+_11537738 1.48 ENST00000379426.2
transmembrane protein 170B
chr8_+_143291384 1.41 ENST00000521537.1
ENST00000518432.5
ENST00000330143.8
ENST00000520333.1
zinc finger protein 696
chr17_+_50095285 1.39 ENST00000503614.5
pyruvate dehydrogenase kinase 2
chr5_-_115262851 1.37 ENST00000379615.3
ENST00000419445.6
protein geranylgeranyltransferase type I subunit beta
chr4_+_127965361 1.36 ENST00000444616.5
abhydrolase domain containing 18
chr14_+_85533167 1.35 ENST00000682132.1
fibronectin leucine rich transmembrane protein 2
chr14_-_81221231 1.32 ENST00000434192.2
general transcription factor IIA subunit 1
chr20_-_45910898 1.31 ENST00000372420.5
phospholipid transfer protein
chrX_-_20141810 1.30 ENST00000379593.1
ENST00000379607.10
eukaryotic translation initiation factor 1A X-linked
chr19_-_52008081 1.28 ENST00000602063.5
ENST00000597747.5
ENST00000594083.5
ENST00000593650.5
ENST00000599631.5
ENST00000598071.6
ENST00000601178.5
ENST00000376716.9
ENST00000391795.7
zinc finger protein 615
chr9_-_97633343 1.27 ENST00000341170.5
thiosulfate sulfurtransferase like domain containing 2
chr21_+_44353607 1.24 ENST00000397928.6
transient receptor potential cation channel subfamily M member 2
chr14_-_81220951 1.24 ENST00000553612.6
general transcription factor IIA subunit 1
chr11_-_68751441 1.18 ENST00000544963.1
ENST00000443940.6
ENST00000255087.10
testis expressed metallothionein like protein
chr2_-_231464475 1.17 ENST00000322723.9
ENST00000678828.1
ENST00000679348.1
ENST00000678246.1
ENST00000678364.1
ENST00000676690.1
nucleolin
chr9_+_706841 1.16 ENST00000382293.7
KN motif and ankyrin repeat domains 1
chr16_+_75222609 1.11 ENST00000495583.1
chymotrypsinogen B1
chr16_-_5065911 1.10 ENST00000472572.8
ENST00000474471.7
chromosome 16 open reading frame 89
chr1_-_20717996 1.09 ENST00000400463.8
ENST00000247986.2
kinesin family member 17
chr15_+_58771280 1.08 ENST00000559228.6
ENST00000450403.3
MINDY lysine 48 deubiquitinase 2
chr16_-_81096163 1.06 ENST00000566566.2
ENST00000569885.6
ENST00000561801.2
ENST00000639689.1
ENST00000638948.1
ENST00000564536.2
ENST00000638192.1
ENST00000640345.1
glycine cleavage system protein H
novel protein
novel protein
chr2_+_112645930 1.05 ENST00000272542.8
solute carrier family 20 member 1
chr3_+_46242453 1.04 ENST00000452454.1
ENST00000395940.3
ENST00000457243.1
C-C motif chemokine receptor 3
chr3_+_46242371 1.04 ENST00000545097.1
C-C motif chemokine receptor 3
chr12_+_6535278 1.02 ENST00000396858.5
glyceraldehyde-3-phosphate dehydrogenase
chr5_+_149141573 0.98 ENST00000506113.5
actin binding LIM protein family member 3
chr7_-_6272639 0.91 ENST00000396741.3
cytohesin 3
chr18_-_46757012 0.91 ENST00000315087.12
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
chr22_+_18077908 0.90 ENST00000329627.11
peroxisomal biogenesis factor 26
chrX_+_153056458 0.85 ENST00000593810.3
PNMA family member 3
chr7_+_74209947 0.83 ENST00000475494.5
ENST00000398475.5
linker for activation of T cells family member 2
chr5_+_179699003 0.83 ENST00000681733.1
ENST00000680006.1
ENST00000680013.1
ENST00000681076.1
ENST00000681168.1
calnexin
chr3_+_38039199 0.83 ENST00000346219.7
ENST00000308059.11
DLEC1 cilia and flagella associated protein
chr4_+_183506082 0.82 ENST00000412117.1
inhibitor of growth family member 2
chr5_+_149141483 0.82 ENST00000326685.11
ENST00000309868.12
actin binding LIM protein family member 3
chr2_+_201116238 0.79 ENST00000342795.9
CASP8 and FADD like apoptosis regulator
chrX_+_153056408 0.78 ENST00000619635.1
PNMA family member 3
chr10_-_11611754 0.78 ENST00000609104.5
USP6 N-terminal like
chr1_-_66924791 0.77 ENST00000371023.7
ENST00000371022.3
ENST00000371026.8
dynein axonemal intermediate chain 4
chrX_+_154295788 0.75 ENST00000369915.8
transketolase like 1
chr5_+_153490727 0.73 ENST00000340592.9
glutamate ionotropic receptor AMPA type subunit 1
chr8_+_17922837 0.73 ENST00000325083.12
pericentriolar material 1
chr17_+_50095331 0.73 ENST00000503176.6
pyruvate dehydrogenase kinase 2
chr6_-_113971120 0.73 ENST00000520895.5
ENST00000521163.5
ENST00000524334.1
ENST00000519065.6
ENST00000368632.6
histone deacetylase 2
chr22_+_18077976 0.69 ENST00000399744.8
peroxisomal biogenesis factor 26
chr5_+_179698906 0.60 ENST00000452673.6
ENST00000680614.1
ENST00000680812.1
ENST00000681265.1
ENST00000680894.1
ENST00000681894.1
ENST00000679642.1
ENST00000680827.1
ENST00000680984.1
ENST00000680042.1
ENST00000681476.1
ENST00000681072.1
ENST00000247461.9
ENST00000502673.6
ENST00000513246.6
ENST00000680618.1
ENST00000680092.1
ENST00000506654.6
calnexin
chr9_-_21240002 0.59 ENST00000380222.4
interferon alpha 14
chr8_+_103021027 0.57 ENST00000518857.5
ENST00000395862.7
ENST00000518738.2
ENST00000521514.5
ATPase H+ transporting V1 subunit C1
chr11_+_64359142 0.55 ENST00000528057.5
ENST00000334205.9
ribosomal protein S6 kinase A4
chr5_+_149141817 0.55 ENST00000504238.5
actin binding LIM protein family member 3
chr17_+_49495286 0.55 ENST00000172229.8
nerve growth factor receptor
chrX_-_154295085 0.54 ENST00000617225.4
ENST00000619903.4
testis expressed 28
chr11_+_46347526 0.53 ENST00000456247.6
ENST00000421244.6
ENST00000318201.12
diacylglycerol kinase zeta
chr2_-_2326161 0.50 ENST00000649810.1
ENST00000648318.1
myelin transcription factor 1 like
chr16_+_283157 0.49 ENST00000219406.11
ENST00000404312.5
ENST00000456379.1
protein disulfide isomerase family A member 2
chr5_-_55233586 0.46 ENST00000282572.5
cyclin O
chr11_+_65386611 0.45 ENST00000531296.1
ENST00000533782.5
ENST00000355991.9
ENST00000317568.10
ENST00000416776.6
ENST00000526201.1
FERM domain containing 8
chr21_+_44012296 0.45 ENST00000291574.9
ENST00000380221.7
trafficking protein particle complex 10
chr20_-_38165261 0.43 ENST00000361475.7
transglutaminase 2
chr16_+_83968244 0.38 ENST00000305202.9
N-terminal EF-hand calcium binding protein 2
chr17_-_44947637 0.34 ENST00000587309.5
ENST00000593135.6
kinesin family member 18B
chr14_+_67619911 0.33 ENST00000261783.4
arginase 2
chr12_+_111766887 0.33 ENST00000416293.7
ENST00000261733.7
aldehyde dehydrogenase 2 family member
chr1_+_239386556 0.32 ENST00000676153.1
cholinergic receptor muscarinic 3
chr14_+_67360313 0.30 ENST00000256383.11
eukaryotic translation initiation factor 2 subunit alpha
chr10_-_131981912 0.30 ENST00000540159.3
BCL2 interacting protein 3
chr10_-_131981948 0.29 ENST00000633835.1
BCL2 interacting protein 3
chr19_+_44777860 0.29 ENST00000341505.4
ENST00000647358.2
Cbl proto-oncogene C
chr2_+_219253243 0.29 ENST00000490341.3
tubulin alpha 4b
chr7_+_149838365 0.27 ENST00000460379.1
ENST00000223210.5
zinc finger protein 862
chr17_-_40937641 0.26 ENST00000209718.8
keratin 23
chr15_+_43826961 0.24 ENST00000381246.6
ENST00000452115.1
ENST00000263795.11
WD repeat domain 76
chr2_-_85888897 0.23 ENST00000639305.1
ENST00000638986.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr6_+_98834560 0.22 ENST00000328345.8
POU class 3 homeobox 2
chr2_-_85888958 0.20 ENST00000377332.8
ENST00000639119.1
ENST00000638572.2
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr1_+_13254212 0.19 ENST00000622421.2
PRAME family member 5
chr19_+_12995554 0.16 ENST00000397661.6
nuclear factor I X
chrX_-_16870325 0.14 ENST00000468092.1
ENST00000404022.5
ENST00000380087.7
RB binding protein 7, chromatin remodeling factor
chr11_-_63608542 0.14 ENST00000540943.1
phospholipase A and acyltransferase 3
chr9_+_128787331 0.14 ENST00000223865.8
TBC1 domain family member 13
chr15_-_23039560 0.12 ENST00000615383.5
ENST00000620435.4
tubulin gamma complex associated protein 5
chr21_+_44350126 0.10 ENST00000300482.9
ENST00000431901.5
transient receptor potential cation channel subfamily M member 2
chr9_+_128787243 0.09 ENST00000372648.10
TBC1 domain family member 13
chr19_+_12995467 0.08 ENST00000592199.6
nuclear factor I X
chr21_-_46155567 0.08 ENST00000291670.9
ENST00000397748.5
ENST00000397743.1
ENST00000397746.8
formimidoyltransferase cyclodeaminase
chr14_+_89955895 0.07 ENST00000393452.7
ENST00000554180.5
ENST00000335725.9
ENST00000393454.6
ENST00000553617.5
ENST00000556867.1
ENST00000553527.1
tyrosyl-DNA phosphodiesterase 1
chr2_+_200305873 0.07 ENST00000439084.5
ENST00000409718.5
spermatogenesis associated serine rich 2 like
chr17_+_47971105 0.06 ENST00000338399.9
ENST00000578018.5
ENST00000579175.5
CDK5 regulatory subunit associated protein 3
chr22_+_24495242 0.05 ENST00000382760.2
ENST00000326010.10
beta-ureidopropionase 1
chr19_+_571274 0.05 ENST00000545507.6
ENST00000346916.9
basigin (Ok blood group)
chr2_-_231464156 0.05 ENST00000453992.6
ENST00000454824.6
ENST00000417652.6
nucleolin
chr2_-_85888685 0.04 ENST00000638178.1
ENST00000640982.1
ENST00000640992.1
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr12_-_55688891 0.04 ENST00000557555.2
integrin subunit alpha 7
chr12_+_31073849 0.00 ENST00000228264.10
ENST00000542838.6
ENST00000438391.6
ENST00000415475.6
ENST00000545668.5
ENST00000350437.8
DEAD/H-box helicase 11

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 78.8 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
2.8 8.5 GO:0036071 N-glycan fucosylation(GO:0036071)
1.3 4.0 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
1.1 4.3 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.7 5.9 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.6 3.0 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.6 1.8 GO:0021779 noradrenergic neuron development(GO:0003358) neuroblast differentiation(GO:0014016) spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780) regulation of timing of neuron differentiation(GO:0060164) olfactory pit development(GO:0060166)
0.6 4.5 GO:0006498 N-terminal protein lipidation(GO:0006498)
0.6 2.8 GO:0035106 operant conditioning(GO:0035106)
0.5 7.9 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.5 2.6 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.5 4.0 GO:0035524 proline transmembrane transport(GO:0035524)
0.5 6.5 GO:0033623 regulation of integrin activation(GO:0033623)
0.4 3.0 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.4 2.4 GO:0043103 hypoxanthine salvage(GO:0043103)
0.4 2.4 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
0.4 14.1 GO:0048665 neuron fate specification(GO:0048665)
0.4 1.1 GO:0098935 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.3 3.1 GO:0071502 cellular response to temperature stimulus(GO:0071502)
0.3 4.5 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.3 1.7 GO:0097029 mature conventional dendritic cell differentiation(GO:0097029)
0.3 1.2 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.3 1.4 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.3 1.3 GO:0042360 vitamin E metabolic process(GO:0042360)
0.3 1.0 GO:0052042 induction of programmed cell death(GO:0012502) peptidyl-cysteine S-trans-nitrosylation(GO:0035606) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501)
0.3 2.3 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 4.4 GO:0015671 oxygen transport(GO:0015671)
0.2 1.1 GO:0019464 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.2 2.0 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.2 31.7 GO:0046718 viral entry into host cell(GO:0046718)
0.2 1.6 GO:0006390 transcription from mitochondrial promoter(GO:0006390)
0.2 4.6 GO:0010842 retina layer formation(GO:0010842)
0.2 1.4 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.2 0.8 GO:0006772 thiamine metabolic process(GO:0006772)
0.1 1.5 GO:1901538 DNA methylation involved in embryo development(GO:0043045) histone H3-K4 trimethylation(GO:0080182) changes to DNA methylation involved in embryo development(GO:1901538)
0.1 0.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.1 7.7 GO:0048488 synaptic vesicle endocytosis(GO:0048488)
0.1 2.6 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 2.7 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 1.6 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.1 0.7 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 2.1 GO:0050812 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.1 4.0 GO:0090383 phagosome acidification(GO:0090383)
0.1 1.0 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.1 6.9 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.1 0.6 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.1 0.6 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
0.1 0.4 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 0.4 GO:1904020 regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021)
0.1 2.2 GO:0051290 protein heterotetramerization(GO:0051290)
0.1 0.3 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.8 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 2.5 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 0.5 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 2.1 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.5 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.0 0.9 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 1.1 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 5.5 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.9 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 2.3 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 1.1 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.6 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 0.3 GO:0006069 ethanol oxidation(GO:0006069)
0.0 0.1 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
0.0 0.3 GO:0000050 urea cycle(GO:0000050)
0.0 0.1 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.0 2.1 GO:0006968 cellular defense response(GO:0006968)
0.0 2.3 GO:1903955 positive regulation of protein targeting to mitochondrion(GO:1903955)
0.0 0.3 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0 0.1 GO:0019482 beta-alanine metabolic process(GO:0019482)
0.0 2.5 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 10.5 GO:0051301 cell division(GO:0051301)
0.0 0.2 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.0 0.1 GO:0000012 single strand break repair(GO:0000012)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 5.9 GO:0044308 axonal spine(GO:0044308)
0.8 6.9 GO:0033391 chromatoid body(GO:0033391)
0.6 1.9 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.5 1.4 GO:0005953 CAAX-protein geranylgeranyltransferase complex(GO:0005953)
0.4 2.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.4 7.7 GO:0001931 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.3 1.5 GO:0001940 male pronucleus(GO:0001940)
0.3 2.6 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.3 1.1 GO:1990075 periciliary membrane compartment(GO:1990075)
0.3 1.1 GO:0005960 glycine cleavage complex(GO:0005960)
0.2 15.8 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.2 82.7 GO:0005874 microtubule(GO:0005874)
0.1 0.6 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.1 3.4 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.1 11.0 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.0 GO:0097452 GAIT complex(GO:0097452)
0.1 0.3 GO:0032279 asymmetric synapse(GO:0032279)
0.1 3.0 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 4.3 GO:0043198 dendritic shaft(GO:0043198)
0.1 1.4 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 3.2 GO:0090545 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1 7.2 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.8 GO:0016580 Sin3 complex(GO:0016580)
0.1 7.8 GO:0005901 caveola(GO:0005901)
0.1 1.6 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.7 GO:0000242 pericentriolar material(GO:0000242)
0.0 2.4 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 1.2 GO:0016592 mediator complex(GO:0016592)
0.0 2.2 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 3.6 GO:0043204 perikaryon(GO:0043204)
0.0 4.5 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 1.7 GO:0035578 azurophil granule lumen(GO:0035578)
0.0 0.7 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.1 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 1.2 GO:0032587 ruffle membrane(GO:0032587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.9 11.8 GO:0052812 phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812)
2.8 8.5 GO:0046921 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
1.0 4.0 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.9 2.8 GO:0016497 substance K receptor activity(GO:0016497)
0.7 3.0 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
0.7 5.9 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.5 4.0 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.5 1.4 GO:0004662 CAAX-protein geranylgeranyltransferase activity(GO:0004662)
0.4 8.7 GO:0031005 filamin binding(GO:0031005)
0.4 1.1 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.4 2.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.3 1.0 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.3 1.0 GO:0035605 peptidyl-cysteine S-nitrosylase activity(GO:0035605)
0.3 4.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.3 2.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.2 31.7 GO:0001618 virus receptor activity(GO:0001618)
0.2 2.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.2 2.6 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.2 84.0 GO:0015631 tubulin binding(GO:0015631)
0.2 0.8 GO:0004802 transketolase activity(GO:0004802)
0.2 0.6 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.2 1.1 GO:0016807 cysteine-type carboxypeptidase activity(GO:0016807) cysteine-type exopeptidase activity(GO:0070004)
0.2 4.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.2 1.6 GO:0050682 AF-2 domain binding(GO:0050682)
0.2 2.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.2 2.4 GO:0070840 dynein complex binding(GO:0070840)
0.1 0.9 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.1 0.4 GO:0031687 A2A adenosine receptor binding(GO:0031687)
0.1 0.5 GO:0047291 neolactotetraosylceramide alpha-2,3-sialyltransferase activity(GO:0004513) lactosylceramide alpha-2,3-sialyltransferase activity(GO:0047291)
0.1 2.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 4.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 3.1 GO:0099604 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.1 2.6 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 2.2 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 6.9 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 3.3 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 13.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 1.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.3 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 1.4 GO:0045499 chemorepellent activity(GO:0045499)
0.1 0.4 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 7.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 3.0 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.5 GO:0097506 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.6 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.6 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 2.4 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.0 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 3.1 GO:0015399 primary active transmembrane transporter activity(GO:0015399) P-P-bond-hydrolysis-driven transmembrane transporter activity(GO:0015405) ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 0.1 GO:0070259 tyrosyl-DNA phosphodiesterase activity(GO:0070259)
0.0 1.6 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.3 GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0 1.6 GO:0051117 ATPase binding(GO:0051117)
0.0 0.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 78.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 15.8 PID RHOA PATHWAY RhoA signaling pathway
0.1 5.8 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 2.3 PID AURORA A PATHWAY Aurora A signaling
0.0 3.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.9 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.0 1.8 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.6 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 3.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.7 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.4 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.3 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 6.3 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 8.5 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.2 4.6 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.2 5.9 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.1 4.0 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.1 4.5 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 2.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1 5.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 2.4 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 1.4 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 2.6 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 4.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 2.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 2.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 1.9 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.0 0.3 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.0 2.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.8 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 1.1 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 0.5 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 1.6 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.0 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.6 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 2.2 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.0 0.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 1.0 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides