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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HES7_HES5
Z-value: 0.79
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Transcription factors associated with HES7_HES5
Network of associatons between targets according to the STRING database.
First level regulatory network of HES7_HES5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.6 | 78.8 | GO:1905098 | negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 0.2 | 31.7 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 0.4 | 14.1 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.0 | 10.5 | GO:0051301 | cell division(GO:0051301) |
| 2.8 | 8.5 | GO:0036071 | N-glycan fucosylation(GO:0036071) |
| 0.5 | 7.9 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
| 0.1 | 7.7 | GO:0048488 | synaptic vesicle endocytosis(GO:0048488) |
| 0.1 | 6.9 | GO:0010501 | RNA secondary structure unwinding(GO:0010501) |
| 0.5 | 6.5 | GO:0033623 | regulation of integrin activation(GO:0033623) |
| 0.7 | 5.9 | GO:0099566 | regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 82.7 | GO:0005874 | microtubule(GO:0005874) |
| 0.2 | 15.8 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.1 | 11.0 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.1 | 7.8 | GO:0005901 | caveola(GO:0005901) |
| 0.4 | 7.7 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.1 | 7.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.8 | 6.9 | GO:0033391 | chromatoid body(GO:0033391) |
| 1.2 | 5.9 | GO:0044308 | axonal spine(GO:0044308) |
| 0.0 | 4.5 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.1 | 4.3 | GO:0043198 | dendritic shaft(GO:0043198) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 84.0 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.2 | 31.7 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 13.0 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 2.9 | 11.8 | GO:0052812 | phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) |
| 0.4 | 8.7 | GO:0031005 | filamin binding(GO:0031005) |
| 2.8 | 8.5 | GO:0046921 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 0.1 | 7.9 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.1 | 6.9 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.7 | 5.9 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.2 | 4.5 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 78.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 15.8 | PID RHOA PATHWAY | RhoA signaling pathway |
| 0.1 | 5.8 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.0 | 3.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 3.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.8 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 1.3 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 0.9 | ST PHOSPHOINOSITIDE 3 KINASE PATHWAY | PI3K Pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.5 | REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI | Genes involved in N-glycan antennae elongation in the medial/trans-Golgi |
| 0.3 | 6.3 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.2 | 5.9 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 5.5 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.2 | 4.6 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.1 | 4.5 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |
| 0.1 | 4.0 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.1 | 4.0 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 2.8 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 2.8 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |