ISMARA results: HIC1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HIC1

Z-value: 2.13

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Transcription factors associated with HIC1

Gene Symbol	Gene ID	Gene Info
HIC1 Ensembl NCBI GeneCards UniProt	ENSG00000177374.13	HIC1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIC1	hg38_v1_chr17_+_2056073_2056310, hg38_v1_chr17_+_2055094_2055110	0.46	1.1e-12	Click!

Activity profile of HIC1 motif

Sorted Z-values of HIC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr16_+_176659 Show fit	57.38	ENST00000320868.9 ENST00000397797.1	HBA1 Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit alpha 1
chr6_-_56954747 Show fit	42.39	ENST00000680361.1	DST Ensembl NCBI GeneCards UniProt Show fit	dystonin
chr16_+_172869 Show fit	40.90	ENST00000251595.11 ENST00000397806.1 ENST00000484216.1	HBA2 Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit alpha 2
chr4_-_108762964 Show fit	37.29	ENST00000512646.5 ENST00000411864.6 ENST00000296486.8 ENST00000510706.5	ETNPPL Ensembl NCBI GeneCards UniProt Show fit	ethanolamine-phosphate phospho-lyase
chr7_-_158829499 Show fit	36.85	ENST00000275418.13	ESYT2 Ensembl NCBI GeneCards UniProt Show fit	extended synaptotagmin 2
chrX_-_2500555 Show fit	36.44	ENST00000381218.8	ZBED1 Ensembl NCBI GeneCards UniProt Show fit	zinc finger BED-type containing 1
chr9_+_127612222 Show fit	36.00	ENST00000637953.1 ENST00000636962.2	STXBP1 Ensembl NCBI GeneCards UniProt Show fit	syntaxin binding protein 1
chr15_+_80404320 Show fit	35.48	ENST00000303329.9 ENST00000622346.4	ARNT2 Ensembl NCBI GeneCards UniProt Show fit	aryl hydrocarbon receptor nuclear translocator 2
chr5_+_134905100 Show fit	34.29	ENST00000512783.5 ENST00000254908.11	PCBD2 Ensembl NCBI GeneCards UniProt Show fit	pterin-4 alpha-carbinolamine dehydratase 2
chr10_+_122461545 Show fit	33.14	ENST00000368984.8	HTRA1 Ensembl NCBI GeneCards UniProt Show fit	HtrA serine peptidase 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.6	91.2	GO:0051823	regulation of synapse structural plasticity(GO:0051823)
0.9	83.1	GO:0006687	glycosphingolipid metabolic process(GO:0006687)
1.2	71.7	GO:0006198	cAMP catabolic process(GO:0006198)
11.2	67.2	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
5.5	65.7	GO:0008090	retrograde axonal transport(GO:0008090)
16.3	65.0	GO:1903294	regulation of glutamate secretion, neurotransmission(GO:1903294) positive regulation of glutamate secretion, neurotransmission(GO:1903296)
2.2	64.7	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
3.0	57.4	GO:0015671	oxygen transport(GO:0015671)
6.8	54.5	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
1.6	54.4	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)

Showing 1 to 10 of 487 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	163.5	GO:0005887	integral component of plasma membrane(GO:0005887)
0.0	116.7	GO:0016021	integral component of membrane(GO:0016021)
0.6	112.9	GO:0070382	exocytic vesicle(GO:0070382)
1.0	109.3	GO:0005905	clathrin-coated pit(GO:0005905)
2.9	98.9	GO:0016327	apicolateral plasma membrane(GO:0016327)
12.6	75.5	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.5	70.7	GO:0032587	ruffle membrane(GO:0032587)
2.8	69.2	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
1.3	63.7	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
12.4	62.0	GO:0031673	H zone(GO:0031673)

Showing 1 to 10 of 187 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	90.0	GO:0017075	syntaxin-1 binding(GO:0017075)
2.0	90.0	GO:0004683	calmodulin-dependent protein kinase activity(GO:0004683)
0.9	80.3	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
1.6	71.7	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
4.8	67.6	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
13.4	67.2	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.2	65.8	GO:0003924	GTPase activity(GO:0003924)
0.5	60.4	GO:0004222	metalloendopeptidase activity(GO:0004222)
2.4	59.3	GO:0051010	microtubule plus-end binding(GO:0051010)
3.8	57.4	GO:0005344	oxygen transporter activity(GO:0005344)

Showing 1 to 10 of 337 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	136.6	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.2	97.2	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
2.1	88.6	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.7	59.3	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.3	55.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	54.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
1.0	45.1	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
1.0	43.8	PID NCADHERIN PATHWAY	N-cadherin signaling events
1.8	43.0	PID LPA4 PATHWAY	LPA4-mediated signaling events
1.7	34.2	PID ALK2 PATHWAY	ALK2 signaling events

Showing 1 to 10 of 82 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	87.3	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
3.9	86.5	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.9	81.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	68.2	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
1.2	62.8	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
2.3	60.9	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
1.0	52.4	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.3	49.3	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.6	45.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
1.0	42.7	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis

Showing 1 to 10 of 124 entries

Results for HIC1

Z-value: 2.13

Motif logo

Transcription factors associated with HIC1

Activity-expression correlation:

Activity profile of HIC1 motif

Sorted Z-values of HIC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: