ISMARA results: HIC2

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HIC2

Z-value: 2.00

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Transcription factors associated with HIC2

Gene Symbol	Gene ID	Gene Info
HIC2 Ensembl NCBI GeneCards UniProt	ENSG00000169635.10	HIC2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIC2	hg38_v1_chr22_+_21420636_21420669	0.20	3.8e-03	Click!

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr12_-_7091873 Show fit	31.17	ENST00000538050.5 ENST00000536053.6	C1R Ensembl NCBI GeneCards UniProt Show fit	complement C1r
chr12_-_14885845 Show fit	28.94	ENST00000539261.6 ENST00000228938.5	MGP Ensembl NCBI GeneCards UniProt Show fit	matrix Gla protein
chr22_+_32801697 Show fit	26.04	ENST00000266085.7	TIMP3 Ensembl NCBI GeneCards UniProt Show fit	TIMP metallopeptidase inhibitor 3
chr12_-_7092422 Show fit	24.96	ENST00000543835.5 ENST00000647956.2 ENST00000535233.6	C1R Ensembl NCBI GeneCards UniProt Show fit	complement C1r
chr13_+_41457543 Show fit	24.00	ENST00000379359.4	RGCC Ensembl NCBI GeneCards UniProt Show fit	regulator of cell cycle
chr9_+_136977496 Show fit	23.22	ENST00000371625.8 ENST00000457950.5	PTGDS Ensembl NCBI GeneCards UniProt Show fit	prostaglandin D2 synthase
chr4_+_25160631 Show fit	21.47	ENST00000510415.1 ENST00000507794.2 ENST00000512921.4	SEPSECS-AS1 Ensembl NCBI GeneCards UniProt Show fit PI4K2B Ensembl NCBI GeneCards UniProt Show fit	SEPSECS antisense RNA 1 (head to head) phosphatidylinositol 4-kinase type 2 beta
chr11_-_5227063 Show fit	21.00	ENST00000335295.4 ENST00000485743.1 ENST00000647020.1	HBB Ensembl NCBI GeneCards UniProt Show fit	hemoglobin subunit beta
chr10_+_122461545 Show fit	19.61	ENST00000368984.8	HTRA1 Ensembl NCBI GeneCards UniProt Show fit	HtrA serine peptidase 1
chr17_+_1771688 Show fit	18.92	ENST00000572048.1 ENST00000573763.1	SERPINF1 Ensembl NCBI GeneCards UniProt Show fit	serpin family F member 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	82.3	GO:0030449	regulation of complement activation(GO:0030449)
0.8	56.6	GO:0006953	acute-phase response(GO:0006953)
0.9	45.0	GO:0050919	negative chemotaxis(GO:0050919)
2.0	42.1	GO:0019371	cyclooxygenase pathway(GO:0019371)
1.4	39.2	GO:0001502	cartilage condensation(GO:0001502)
8.3	33.2	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.2	32.3	GO:0030073	insulin secretion(GO:0030073)
7.7	30.9	GO:1902528	regulation of protein linear polyubiquitination(GO:1902528) positive regulation of protein linear polyubiquitination(GO:1902530)
0.7	29.6	GO:0090314	positive regulation of protein targeting to membrane(GO:0090314)
2.8	28.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)

Showing 1 to 10 of 633 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	310.3	GO:0005615	extracellular space(GO:0005615)
0.1	180.2	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.3	110.9	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.8	90.0	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.5	87.0	GO:0072562	blood microparticle(GO:0072562)
0.3	79.5	GO:0016323	basolateral plasma membrane(GO:0016323)
0.3	44.9	GO:0031225	anchored component of membrane(GO:0031225)
1.2	38.1	GO:0032809	neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.2	37.4	GO:0098793	presynapse(GO:0098793)
1.9	34.2	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)

Showing 1 to 10 of 219 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	197.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.0	102.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.8	65.3	GO:0005201	extracellular matrix structural constituent(GO:0005201)
2.7	51.6	GO:0038191	neuropilin binding(GO:0038191)
1.6	45.7	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.8	43.2	GO:0005158	insulin receptor binding(GO:0005158)
0.9	42.5	GO:0008009	chemokine activity(GO:0008009)
10.3	41.2	GO:0004667	prostaglandin-D synthase activity(GO:0004667)
0.7	40.4	GO:0070412	R-SMAD binding(GO:0070412)
0.6	37.2	GO:0030507	spectrin binding(GO:0030507)

Showing 1 to 10 of 434 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	197.6	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	103.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6	100.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.1	76.2	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3	59.2	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.8	58.2	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.6	44.6	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.7	33.4	NABA COLLAGENS	Genes encoding collagen proteins
0.8	33.2	PID TCR CALCIUM PATHWAY	Calcium signaling in the CD4+ TCR pathway
0.4	27.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks

Showing 1 to 10 of 93 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	124.0	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.4	45.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.7	40.7	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
0.6	40.0	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
1.6	39.6	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.2	38.8	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
1.0	32.5	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
1.7	31.4	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
1.6	31.4	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.6	30.4	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases

Showing 1 to 10 of 139 entries

Results for HIC2

Z-value: 2.00

Motif logo

Transcription factors associated with HIC2

Activity-expression correlation:

Activity profile of HIC2 motif

Sorted Z-values of HIC2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HIC2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: