ISMARA results: HIF1A

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for HIF1A

Z-value: 0.93

Motif logo

Transcription factors associated with HIF1A

Gene Symbol	Gene ID	Gene Info
HIF1A Ensembl NCBI GeneCards UniProt	ENSG00000100644.17	HIF1A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HIF1A	hg38_v1_chr14_+_61695435_61695598, hg38_v1_chr14_+_61695777_61695813, hg38_v1_chr14_+_61697622_61697717	0.62	1.5e-24	Click!

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr1_-_8879170 Show fit	37.39	ENST00000489867.2	ENO1 Ensembl NCBI GeneCards UniProt Show fit	enolase 1
chr1_-_8878706 Show fit	24.15	ENST00000646156.1	ENO1 Ensembl NCBI GeneCards UniProt Show fit	enolase 1
chr3_-_196082078 Show fit	23.06	ENST00000360110.9 ENST00000392396.7 ENST00000420415.5	TFRC Ensembl NCBI GeneCards UniProt Show fit	transferrin receptor
chr1_-_8878646 Show fit	21.64	ENST00000643438.1	ENO1 Ensembl NCBI GeneCards UniProt Show fit	enolase 1
chr1_-_25906457 Show fit	21.01	ENST00000426559.6	STMN1 Ensembl NCBI GeneCards UniProt Show fit	stathmin 1
chrX_+_78104229 Show fit	20.07	ENST00000373316.5	PGK1 Ensembl NCBI GeneCards UniProt Show fit	phosphoglycerate kinase 1
chr11_-_14643617 Show fit	19.23	ENST00000418988.2	PSMA1 Ensembl NCBI GeneCards UniProt Show fit	proteasome 20S subunit alpha 1
chr3_-_81761636 Show fit	18.11	ENST00000429644.7	GBE1 Ensembl NCBI GeneCards UniProt Show fit	1,4-alpha-glucan branching enzyme 1
chr3_-_146161167 Show fit	17.95	ENST00000360060.7 ENST00000282903.10	PLOD2 Ensembl NCBI GeneCards UniProt Show fit	procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
chr1_-_8878677 Show fit	16.97	ENST00000234590.10 ENST00000647408.1	ENO1 Ensembl NCBI GeneCards UniProt Show fit	enolase 1

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
9.1	100.1	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
3.8	45.5	GO:1905098	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.3	31.1	GO:0002181	cytoplasmic translation(GO:0002181)
1.3	23.1	GO:0045780	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
1.8	22.8	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
1.3	22.5	GO:0006089	lactate metabolic process(GO:0006089)
0.2	21.2	GO:0006521	regulation of cellular amino acid metabolic process(GO:0006521)
1.0	20.1	GO:0031639	plasminogen activation(GO:0031639)
2.5	19.8	GO:0034625	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	19.8	GO:0045087	innate immune response(GO:0045087)

Showing 1 to 10 of 153 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
12.5	100.1	GO:0000015	phosphopyruvate hydratase complex(GO:0000015)
0.0	81.5	GO:0070062	extracellular exosome(GO:0070062)
0.2	42.7	GO:0043209	myelin sheath(GO:0043209)
0.3	31.0	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.1	30.0	GO:0005874	microtubule(GO:0005874)
1.0	26.2	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.3	21.6	GO:0015030	Cajal body(GO:0015030)
1.7	20.5	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
1.6	19.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
1.4	19.2	GO:1990712	HFE-transferrin receptor complex(GO:1990712)

Showing 1 to 10 of 80 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
12.5	100.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.2	46.0	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	32.0	GO:0015631	tubulin binding(GO:0015631)
0.9	28.5	GO:0008266	poly(U) RNA binding(GO:0008266)
0.6	27.6	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.4	26.1	GO:0003743	translation initiation factor activity(GO:0003743)
7.7	23.1	GO:0004998	transferrin receptor activity(GO:0004998)
3.2	22.5	GO:0004457	lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
2.0	21.7	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
6.7	20.1	GO:0004618	phosphoglycerate kinase activity(GO:0004618)

Showing 1 to 10 of 118 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	182.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
2.4	49.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.5	44.7	PID ILK PATHWAY	Integrin-linked kinase signaling
0.8	42.1	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.1	25.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	21.8	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.3	16.7	PID PLK1 PATHWAY	PLK1 signaling events
0.5	12.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.3	9.9	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	8.8	PID FANCONI PATHWAY	Fanconi anemia pathway

Showing 1 to 10 of 24 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	146.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
1.3	38.1	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.5	37.5	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.4	31.5	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.3	31.0	REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION	Genes involved in 3' -UTR-mediated translational regulation
0.8	28.5	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.7	25.7	REACTOME MEIOTIC RECOMBINATION	Genes involved in Meiotic Recombination
0.2	24.0	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.4	23.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.6	19.8	REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS	Genes involved in Synthesis of very long-chain fatty acyl-CoAs

Showing 1 to 10 of 54 entries

Results for HIF1A

Z-value: 0.93

Motif logo

Transcription factors associated with HIF1A

Activity-expression correlation:

Activity profile of HIF1A motif

Sorted Z-values of HIF1A motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HIF1A

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: