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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HINFP
Z-value: 0.56
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Transcription factors associated with HINFP
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HINFP | hg38_v1_chr11_+_119121559_119121624 | 0.07 | 3.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HINFP
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_94394886 Show fit | 10.15 |
ENST00000297268.11
ENST00000620463.1 |
collagen type I alpha 2 chain |
|
| chr11_-_125592448 Show fit | 6.23 |
ENST00000648911.1
|
fasciculation and elongation protein zeta 1 |
|
| chr6_-_106975616 Show fit | 5.90 |
ENST00000610952.1
|
CD24 molecule |
|
| chr6_-_106975452 Show fit | 5.84 |
ENST00000619869.1
ENST00000619133.4 |
CD24 molecule |
|
| chr8_-_27605271 Show fit | 5.67 |
ENST00000522098.1
|
clusterin |
|
| chr5_+_176238365 Show fit | 5.42 |
ENST00000341199.10
ENST00000430704.6 ENST00000443967.5 ENST00000429602.7 |
SUMO interacting motifs containing 1 |
|
| chr6_-_106975309 Show fit | 4.81 |
ENST00000615659.1
|
CD24 molecule |
|
| chr4_-_499102 Show fit | 4.29 |
ENST00000338977.5
ENST00000511833.3 |
zinc finger protein 721 |
|
| chr16_-_23557331 Show fit | 3.96 |
ENST00000563232.1
ENST00000449606.7 |
glutamyl-tRNA synthetase 2, mitochondrial |
|
| chr9_+_128203397 Show fit | 3.50 |
ENST00000628346.2
ENST00000486160.3 ENST00000627061.2 ENST00000627543.2 ENST00000634267.2 |
dynamin 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 16.6 | GO:0032595 | B cell receptor transport within lipid bilayer(GO:0032595) B cell receptor transport into membrane raft(GO:0032597) protein transport out of membrane raft(GO:0032599) chemokine receptor transport out of membrane raft(GO:0032600) negative regulation of transforming growth factor beta3 production(GO:0032913) chemokine receptor transport within lipid bilayer(GO:0033606) |
| 0.7 | 10.2 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.8 | 9.9 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 1.5 | 7.6 | GO:0035801 | adrenal cortex development(GO:0035801) adrenal cortex formation(GO:0035802) |
| 0.1 | 7.6 | GO:0031338 | regulation of vesicle fusion(GO:0031338) |
| 2.3 | 6.9 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 0.7 | 6.2 | GO:1902902 | negative regulation of autophagosome assembly(GO:1902902) |
| 1.1 | 5.7 | GO:1902847 | regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998) |
| 0.8 | 4.7 | GO:0032383 | regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383) |
| 0.8 | 4.1 | GO:0071494 | cellular response to UV-C(GO:0071494) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 16.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.8 | 10.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 9.9 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 7.8 | GO:0099572 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.1 | 6.9 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 6.5 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.4 | 5.7 | GO:0097418 | neurofibrillary tangle(GO:0097418) |
| 0.1 | 5.7 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 5.5 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.5 | 4.7 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 26.4 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.4 | 13.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.8 | 10.2 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.1 | 9.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.0 | 8.5 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 6.2 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 5.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.3 | 5.7 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 1.4 | 5.4 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 1.0 | 5.1 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.1 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.3 | 9.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 9.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 8.1 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 6.9 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.1 | 5.0 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.1 | 4.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.2 | 4.1 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 3.9 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.1 | 3.1 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.4 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 0.6 | 10.2 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.3 | 9.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.3 | 6.9 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 0.0 | 5.2 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 4.7 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.0 | 4.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 4.2 | REACTOME CGMP EFFECTS | Genes involved in cGMP effects |
| 0.0 | 4.1 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.2 | 4.0 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |