Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for HIVEP1
Z-value: 1.62
Motif logo
Transcription factors associated with HIVEP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HIVEP1 | hg38_v1_chr6_+_12012304_12012338 | 0.14 | 4.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HIVEP1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 154.4 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.0 | 116.3 | GO:0031295 | T cell costimulation(GO:0031295) |
| 1.0 | 102.0 | GO:0050672 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 8.5 | 84.5 | GO:0002480 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480) |
| 0.7 | 68.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 22.6 | 67.7 | GO:0002503 | peptide antigen assembly with MHC class II protein complex(GO:0002503) |
| 5.4 | 65.4 | GO:2001199 | negative regulation of dendritic cell differentiation(GO:2001199) |
| 8.9 | 62.6 | GO:0000255 | allantoin metabolic process(GO:0000255) |
| 17.7 | 53.2 | GO:0035691 | macrophage migration inhibitory factor signaling pathway(GO:0035691) |
| 11.5 | 34.4 | GO:0034147 | regulation of toll-like receptor 5 signaling pathway(GO:0034147) negative regulation of toll-like receptor 5 signaling pathway(GO:0034148) negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070429) tolerance induction to lipopolysaccharide(GO:0072573) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.6 | 220.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 2.6 | 131.4 | GO:0019814 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 7.7 | 84.5 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 83.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 2.1 | 46.0 | GO:0001931 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 3.3 | 43.4 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 41.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.1 | 35.3 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.4 | 27.0 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.3 | 25.9 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 154.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 10.7 | 149.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.6 | 88.1 | GO:0003823 | antigen binding(GO:0003823) |
| 10.6 | 53.2 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 1.8 | 45.9 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 6.4 | 38.6 | GO:0046979 | TAP2 binding(GO:0046979) |
| 2.5 | 34.4 | GO:0061578 | Lys63-specific deubiquitinase activity(GO:0061578) |
| 0.1 | 32.0 | GO:0004713 | protein tyrosine kinase activity(GO:0004713) |
| 0.3 | 26.7 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.7 | 25.2 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 64.3 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 1.3 | 64.2 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 2.5 | 62.6 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 1.1 | 53.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 1.0 | 53.6 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.8 | 34.2 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.7 | 30.9 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 1.0 | 23.5 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.4 | 18.0 | PID THROMBIN PAR1 PATHWAY | PAR1-mediated thrombin signaling events |
| 0.2 | 17.5 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 84.5 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 3.8 | 79.8 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.8 | 70.3 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.5 | 68.7 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 3.1 | 64.1 | REACTOME IL 7 SIGNALING | Genes involved in Interleukin-7 signaling |
| 0.9 | 44.4 | REACTOME GPVI MEDIATED ACTIVATION CASCADE | Genes involved in GPVI-mediated activation cascade |
| 0.8 | 35.5 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 1.0 | 20.6 | REACTOME CD28 DEPENDENT PI3K AKT SIGNALING | Genes involved in CD28 dependent PI3K/Akt signaling |
| 0.7 | 17.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 2.4 | 17.1 | REACTOME PD1 SIGNALING | Genes involved in PD-1 signaling |