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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HMBOX1
Z-value: 0.85
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Transcription factors associated with HMBOX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMBOX1 | hg38_v1_chr8_+_28890365_28890421 | -0.34 | 3.4e-07 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMBOX1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_152036984 Show fit | 29.27 |
ENST00000271638.3
|
S100 calcium binding protein A11 |
|
| chr6_+_27147094 Show fit | 27.68 |
ENST00000377459.3
|
H2A clustered histone 12 |
|
| chr3_+_33114033 Show fit | 20.26 |
ENST00000449224.1
|
cartilage associated protein |
|
| chrX_-_20218941 Show fit | 16.18 |
ENST00000457145.6
|
ribosomal protein S6 kinase A3 |
|
| chr14_+_55611977 Show fit | 15.96 |
ENST00000395309.7
ENST00000413890.6 |
kinectin 1 |
|
| chr9_+_73151833 Show fit | 15.87 |
ENST00000456643.5
ENST00000257497.11 ENST00000415424.5 |
annexin A1 |
|
| chr3_-_149377637 Show fit | 14.51 |
ENST00000305366.8
|
transmembrane 4 L six family member 1 |
|
| chr1_+_40988513 Show fit | 14.12 |
ENST00000649215.1
|
CTP synthase 1 |
|
| chr14_+_34993240 Show fit | 13.31 |
ENST00000677647.1
|
signal recognition particle 54 |
|
| chr6_-_8102481 Show fit | 13.08 |
ENST00000502429.5
ENST00000429723.6 ENST00000379715.10 ENST00000507463.1 |
eukaryotic translation elongation factor 1 epsilon 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 31.5 | GO:0035372 | protein localization to microtubule(GO:0035372) |
| 0.3 | 24.3 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 7.8 | 23.3 | GO:1901874 | negative regulation of post-translational protein modification(GO:1901874) |
| 0.5 | 16.2 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 0.1 | 16.0 | GO:0007018 | microtubule-based movement(GO:0007018) |
| 5.3 | 15.9 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.6 | 15.4 | GO:2000009 | negative regulation of protein localization to cell surface(GO:2000009) |
| 0.1 | 14.2 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 3.5 | 14.1 | GO:0044210 | 'de novo' CTP biosynthetic process(GO:0044210) |
| 3.3 | 13.3 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 39.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.4 | 31.5 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.2 | 28.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.2 | 19.4 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 1.9 | 17.0 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 2.6 | 15.9 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.1 | 14.5 | GO:0001650 | fibrillar center(GO:0001650) |
| 2.2 | 13.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.9 | 13.0 | GO:0030478 | actin cap(GO:0030478) |
| 0.9 | 12.8 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 31.1 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 1.2 | 29.3 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 18.8 | GO:0032403 | protein complex binding(GO:0032403) |
| 0.3 | 18.6 | GO:0019894 | kinesin binding(GO:0019894) |
| 2.8 | 17.0 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
| 0.4 | 16.2 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 3.2 | 15.9 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 15.1 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.3 | 14.6 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 14.6 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 17.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 16.2 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.4 | 15.1 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.2 | 11.8 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.2 | 11.5 | PID MYC PATHWAY | C-MYC pathway |
| 0.6 | 11.3 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.2 | 9.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 5.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 5.6 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.8 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 23.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.2 | 17.9 | REACTOME ER PHAGOSOME PATHWAY | Genes involved in ER-Phagosome pathway |
| 0.1 | 17.0 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.4 | 16.2 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.1 | 14.9 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 1.5 | 13.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 0.5 | 12.7 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 0.3 | 11.2 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.3 | 10.4 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |