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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HMGA1
Z-value: 1.04
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Transcription factors associated with HMGA1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMGA1 | hg38_v1_chr6_+_34236865_34236887 | -0.20 | 3.5e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMGA1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_13817346 Show fit | 33.57 |
ENST00000356942.9
|
glycoprotein M6B |
|
| chrX_+_103776493 Show fit | 18.03 |
ENST00000433491.5
ENST00000612423.4 ENST00000443502.5 |
proteolipid protein 1 |
|
| chr10_+_119819244 Show fit | 16.00 |
ENST00000637174.1
|
inositol polyphosphate-5-phosphatase F |
|
| chr4_-_142305826 Show fit | 14.80 |
ENST00000514525.1
|
inositol polyphosphate-4-phosphatase type II B |
|
| chr4_+_87975667 Show fit | 13.49 |
ENST00000237623.11
ENST00000682655.1 ENST00000508233.6 ENST00000360804.4 ENST00000395080.8 |
secreted phosphoprotein 1 |
|
| chr3_+_319683 Show fit | 13.36 |
ENST00000620033.4
|
cell adhesion molecule L1 like |
|
| chr12_-_16600703 Show fit | 11.67 |
ENST00000616247.4
|
LIM domain only 3 |
|
| chr2_-_224947030 Show fit | 11.66 |
ENST00000409592.7
|
dedicator of cytokinesis 10 |
|
| chr2_+_148978361 Show fit | 11.25 |
ENST00000678720.1
ENST00000678856.1 ENST00000677080.1 |
kinesin family member 5C |
|
| chr4_+_87975829 Show fit | 10.24 |
ENST00000614857.5
|
secreted phosphoprotein 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 50.4 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 7.9 | 23.7 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.2 | 22.8 | GO:0043647 | inositol phosphate metabolic process(GO:0043647) |
| 0.2 | 20.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.5 | 19.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.9 | 18.0 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 2.4 | 17.1 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 4.0 | 16.0 | GO:0031161 | phosphatidylinositol catabolic process(GO:0031161) |
| 0.1 | 15.6 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 2.3 | 13.8 | GO:0097338 | response to clozapine(GO:0097338) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 25.0 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.1 | 22.1 | GO:0045121 | membrane raft(GO:0045121) |
| 0.2 | 20.9 | GO:0045334 | clathrin-coated endocytic vesicle(GO:0045334) |
| 0.1 | 19.4 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 15.8 | GO:0030425 | dendrite(GO:0030425) |
| 0.1 | 15.5 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.1 | 13.7 | GO:0030427 | site of polarized growth(GO:0030427) |
| 0.6 | 13.2 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.8 | 11.8 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.1 | 11.6 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 28.2 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 4.0 | 20.2 | GO:0016316 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828) |
| 0.7 | 18.7 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 1.5 | 18.0 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 2.0 | 16.0 | GO:0052832 | inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834) |
| 0.0 | 14.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.9 | 13.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 13.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.2 | 12.0 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 10.2 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 41.1 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 10.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 9.7 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.1 | 7.8 | PID ATR PATHWAY | ATR signaling pathway |
| 0.2 | 7.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 7.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 7.0 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 6.1 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 6.1 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.2 | 5.3 | PID S1P S1P4 PATHWAY | S1P4 pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 22.7 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.5 | 19.1 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 0.2 | 13.9 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.4 | 13.1 | REACTOME DCC MEDIATED ATTRACTIVE SIGNALING | Genes involved in DCC mediated attractive signaling |
| 0.3 | 11.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 11.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.1 | 11.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 8.4 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.3 | 7.6 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 7.1 | REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS | Genes involved in Association of TriC/CCT with target proteins during biosynthesis |