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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HMGA2
Z-value: 0.54
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Transcription factors associated with HMGA2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMGA2 | hg38_v1_chr12_+_65824818_65824898 | 0.39 | 4.1e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMGA2
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.4 | GO:1904659 | hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659) |
| 1.1 | 6.8 | GO:0071395 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.2 | 6.7 | GO:0042572 | retinol metabolic process(GO:0042572) |
| 1.0 | 6.3 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.5 | 6.2 | GO:0035751 | regulation of lysosomal lumen pH(GO:0035751) |
| 0.3 | 6.0 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.2 | 5.5 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 1.8 | 5.4 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 0.4 | 5.4 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 5.3 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.4 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.0 | 9.0 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 8.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 6.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.6 | 6.2 | GO:0071439 | clathrin complex(GO:0071439) |
| 1.1 | 5.5 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.5 | 5.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 4.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 1.0 | 3.9 | GO:0002945 | cyclin K-CDK13 complex(GO:0002945) |
| 0.1 | 3.5 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 16.4 | GO:0005355 | glucose transmembrane transporter activity(GO:0005355) |
| 0.5 | 11.7 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 1.4 | 6.8 | GO:0047086 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115) |
| 0.1 | 6.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 5.9 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.5 | 5.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.7 | 5.4 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 5.4 | GO:0016504 | peptidase activator activity(GO:0016504) |
| 0.1 | 5.3 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 1.0 | 4.8 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 6.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.2 | 5.4 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 4.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 3.5 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 3.3 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 3.2 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 2.9 | PID HIV NEF PATHWAY | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| 0.0 | 2.3 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.4 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.0 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.1 | 13.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 5.9 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.2 | 5.4 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.2 | 5.0 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 4.8 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.1 | 4.5 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.0 | 3.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.2 | 3.5 | REACTOME PYRIMIDINE CATABOLISM | Genes involved in Pyrimidine catabolism |
| 0.0 | 3.3 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |