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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HMX1
Z-value: 1.13
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Transcription factors associated with HMX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HMX1 | hg38_v1_chr4_-_8871817_8871857 | -0.70 | 4.0e-33 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HMX1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 49.6 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 7.8 | 39.2 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 2.9 | 34.4 | GO:0070495 | regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098) |
| 6.8 | 33.8 | GO:0033383 | geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337) |
| 2.5 | 32.7 | GO:0021769 | orbitofrontal cortex development(GO:0021769) |
| 0.8 | 26.7 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 1.7 | 26.1 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 8.7 | 26.0 | GO:0034238 | macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239) positive regulation of macrophage fusion(GO:0034241) |
| 3.2 | 26.0 | GO:0046604 | positive regulation of mitotic centrosome separation(GO:0046604) |
| 1.5 | 23.6 | GO:2000828 | parathyroid hormone secretion(GO:0035898) post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 39.2 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.4 | 33.7 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.2 | 33.3 | GO:0016363 | nuclear matrix(GO:0016363) |
| 1.6 | 32.7 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 1.0 | 32.0 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.6 | 31.1 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.3 | 21.6 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 20.9 | GO:0030496 | midbody(GO:0030496) |
| 0.4 | 19.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.2 | 19.1 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.8 | 43.2 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 9.8 | 39.2 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 6.8 | 33.8 | GO:0004161 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.1 | 32.4 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 29.5 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.4 | 27.8 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 1.0 | 26.7 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.6 | 26.0 | GO:0043236 | laminin binding(GO:0043236) |
| 1.0 | 23.6 | GO:0051430 | mu-type opioid receptor binding(GO:0031852) corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430) |
| 0.5 | 22.5 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 42.7 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.4 | 34.1 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.8 | 32.2 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.6 | 28.7 | PID IL8 CXCR2 PATHWAY | IL8- and CXCR2-mediated signaling events |
| 0.3 | 24.5 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.2 | 21.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 19.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 19.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 17.5 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.5 | 16.9 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.6 | 39.2 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |
| 0.8 | 36.9 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.8 | 33.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.3 | 31.8 | REACTOME LATE PHASE OF HIV LIFE CYCLE | Genes involved in Late Phase of HIV Life Cycle |
| 0.7 | 29.0 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.2 | 25.5 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.7 | 23.6 | REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR | Genes involved in Prostacyclin signalling through prostacyclin receptor |
| 0.5 | 22.2 | REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS | Genes involved in Regulation of Water Balance by Renal Aquaporins |
| 1.9 | 16.9 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 1.2 | 14.8 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |