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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HMX3
Z-value: 0.86
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Transcription factors associated with HMX3
Network of associatons between targets according to the STRING database.
First level regulatory network of HMX3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_151025343 Show fit | 22.42 |
ENST00000521632.1
|
glutathione peroxidase 3 |
|
| chr4_-_87529092 Show fit | 19.18 |
ENST00000503414.5
|
SPARC like 1 |
|
| chr17_-_69150062 Show fit | 14.05 |
ENST00000522787.5
ENST00000521538.5 |
ATP binding cassette subfamily A member 10 |
|
| chr4_+_25160631 Show fit | 13.86 |
ENST00000510415.1
ENST00000507794.2 ENST00000512921.4 |
SEPSECS antisense RNA 1 (head to head) phosphatidylinositol 4-kinase type 2 beta |
|
| chr12_-_91179355 Show fit | 13.37 |
ENST00000550563.5
ENST00000546370.5 |
decorin |
|
| chrX_+_38561530 Show fit | 10.87 |
ENST00000378482.7
ENST00000286824.6 |
tetraspanin 7 |
|
| chr12_-_9115907 Show fit | 10.72 |
ENST00000318602.12
|
alpha-2-macroglobulin |
|
| chr2_-_89100352 Show fit | 10.49 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr11_-_129024157 Show fit | 10.06 |
ENST00000392657.7
|
Rho GTPase activating protein 32 |
|
| chr17_-_81131933 Show fit | 9.83 |
ENST00000417379.6
|
apoptosis associated tyrosine kinase |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 35.6 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 7.5 | 22.4 | GO:0006982 | response to lipid hydroperoxide(GO:0006982) |
| 0.1 | 22.0 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 0.1 | 21.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 6.6 | 19.9 | GO:0001869 | regulation of complement activation, lectin pathway(GO:0001868) negative regulation of complement activation, lectin pathway(GO:0001869) |
| 0.0 | 16.9 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 2.5 | 14.8 | GO:1903282 | negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470) |
| 0.3 | 14.0 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.1 | 13.8 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 1.1 | 13.7 | GO:0070327 | thyroid hormone transport(GO:0070327) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 76.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.0 | 68.2 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 52.3 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 2.7 | 35.6 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 34.4 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.7 | 27.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.3 | 27.0 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 25.9 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.9 | 16.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 16.1 | GO:0043204 | perikaryon(GO:0043204) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 54.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 29.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 28.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.1 | 25.1 | GO:0008430 | selenium binding(GO:0008430) |
| 0.2 | 24.1 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 17.5 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 2.5 | 14.8 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.5 | 14.7 | GO:0071949 | FAD binding(GO:0071949) |
| 2.3 | 13.9 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.1 | 11.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 51.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 32.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 18.3 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 16.5 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 13.9 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 10.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 9.1 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.2 | 8.4 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 8.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 6.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 36.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.5 | 22.0 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.9 | 20.8 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |
| 0.5 | 19.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.2 | 18.9 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.6 | 14.1 | REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS | Genes involved in ABCA transporters in lipid homeostasis |
| 0.7 | 13.9 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.2 | 13.2 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.6 | 12.8 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.1 | 12.7 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |