ISMARA results: HNF4A

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HNF4A

Z-value: 1.14

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Transcription factors associated with HNF4A

Gene Symbol	Gene ID	Gene Info
HNF4A Ensembl NCBI GeneCards UniProt	ENSG00000101076.18	HNF4A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HNF4A	hg38_v1_chr20_+_44401269_44401301	0.59	8.4e-22	Click!

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

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Promoter	Score	Transcript	Gene	Gene Info
chr5_-_42811884 Show fit	26.99	ENST00000514985.6 ENST00000511224.5 ENST00000507920.5 ENST00000510965.1	SELENOP Ensembl NCBI GeneCards UniProt Show fit	selenoprotein P
chr6_+_31982057 Show fit	23.68	ENST00000428956.7 ENST00000498271.1	C4A Ensembl NCBI GeneCards UniProt Show fit	complement C4A (Rodgers blood group)
chr6_+_32014795 Show fit	23.22	ENST00000435363.7 ENST00000425700.3	C4B Ensembl NCBI GeneCards UniProt Show fit	complement C4B (Chido blood group)
chr9_-_101442403 Show fit	20.66	ENST00000648758.1	ALDOB Ensembl NCBI GeneCards UniProt Show fit	aldolase, fructose-bisphosphate B
chr1_-_15585015 Show fit	20.64	ENST00000375826.4	AGMAT Ensembl NCBI GeneCards UniProt Show fit	agmatinase
chr16_+_8674605 Show fit	17.83	ENST00000268251.13	ABAT Ensembl NCBI GeneCards UniProt Show fit	4-aminobutyrate aminotransferase
chr20_+_57561103 Show fit	17.10	ENST00000319441.6	PCK1 Ensembl NCBI GeneCards UniProt Show fit	phosphoenolpyruvate carboxykinase 1
chr17_+_43780425 Show fit	16.53	ENST00000449302.8	CFAP97D1 Ensembl NCBI GeneCards UniProt Show fit	CFAP97 domain containing 1
chr6_+_31946086 Show fit	13.35	ENST00000425368.7	CFB Ensembl NCBI GeneCards UniProt Show fit	complement factor B
chr9_+_136945234 Show fit	12.45	ENST00000371634.7	C8G Ensembl NCBI GeneCards UniProt Show fit	complement C8 gamma chain

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	46.9	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
4.5	31.8	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
3.4	27.0	GO:0001887	selenium compound metabolic process(GO:0001887)
3.8	26.9	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
1.3	25.8	GO:0006957	complement activation, alternative pathway(GO:0006957)
3.4	23.6	GO:0016098	monoterpenoid metabolic process(GO:0016098)
3.4	20.7	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
4.1	20.6	GO:1901162	primary amino compound biosynthetic process(GO:1901162)
0.6	20.3	GO:0043252	sodium-independent organic anion transport(GO:0043252)
4.7	18.8	GO:0006562	proline catabolic process(GO:0006562)

Showing 1 to 10 of 124 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	62.7	GO:0072562	blood microparticle(GO:0072562)
0.0	42.7	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	42.5	GO:0005615	extracellular space(GO:0005615)
0.0	33.3	GO:0031226	intrinsic component of plasma membrane(GO:0031226)
0.1	30.5	GO:0016323	basolateral plasma membrane(GO:0016323)
1.3	27.0	GO:0031089	platelet dense granule lumen(GO:0031089)
0.3	21.1	GO:0031526	brush border membrane(GO:0031526)
0.5	20.7	GO:0034451	centriolar satellite(GO:0034451)
2.6	18.5	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.1	18.1	GO:0005796	Golgi lumen(GO:0005796)

Showing 1 to 10 of 58 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	49.0	GO:0001848	complement binding(GO:0001848)
1.9	30.2	GO:0008391	arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
2.2	27.0	GO:0008430	selenium binding(GO:0008430)
4.5	26.9	GO:0031708	endothelin B receptor binding(GO:0031708)
3.4	23.7	GO:0001849	complement component C1q binding(GO:0001849)
0.8	23.7	GO:0071949	FAD binding(GO:0071949)
6.9	20.7	GO:0061609	fructose-1-phosphate aldolase activity(GO:0061609)
1.4	20.6	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
4.6	18.5	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
4.5	17.8	GO:0047298	4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298)

Showing 1 to 10 of 109 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	62.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	26.9	PID ENDOTHELIN PATHWAY	Endothelins
0.1	20.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	18.2	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	16.9	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.2	13.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.6	13.4	ST G ALPHA S PATHWAY	G alpha s Pathway
0.2	12.3	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	11.0	PID LKB1 PATHWAY	LKB1 signaling events
0.2	11.0	PID HNF3A PATHWAY	FOXA1 transcription factor network

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	50.4	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
2.0	38.3	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.2	37.4	REACTOME G ALPHA Q SIGNALLING EVENTS	Genes involved in G alpha (q) signalling events
1.4	31.8	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.4	25.1	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	24.9	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.2	22.8	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
1.0	20.6	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.4	17.8	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
1.1	17.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism

Showing 1 to 10 of 47 entries

Results for HNF4A

Z-value: 1.14

Motif logo

Transcription factors associated with HNF4A

Activity-expression correlation:

Activity profile of HNF4A motif

Sorted Z-values of HNF4A motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF4A

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: