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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOMEZ
Z-value: 1.18
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Transcription factors associated with HOMEZ
Network of associatons between targets according to the STRING database.
First level regulatory network of HOMEZ
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 61.4 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 1.6 | 57.1 | GO:0006293 | nucleotide-excision repair, preincision complex stabilization(GO:0006293) |
| 13.3 | 40.0 | GO:1902524 | positive regulation of protein K48-linked ubiquitination(GO:1902524) |
| 0.6 | 38.5 | GO:0006283 | transcription-coupled nucleotide-excision repair(GO:0006283) |
| 2.3 | 34.5 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 4.2 | 33.8 | GO:0006659 | phosphatidylserine biosynthetic process(GO:0006659) |
| 0.4 | 33.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.3 | 32.7 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 7.0 | 28.2 | GO:0002188 | translation reinitiation(GO:0002188) |
| 2.5 | 27.5 | GO:2000645 | negative regulation of receptor catabolic process(GO:2000645) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 67.6 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.4 | 55.1 | GO:0001741 | XY body(GO:0001741) |
| 0.2 | 52.5 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.1 | 47.7 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 2.1 | 36.9 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.3 | 36.3 | GO:0005901 | caveola(GO:0005901) |
| 0.2 | 30.5 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.4 | 29.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 29.2 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 2.2 | 28.7 | GO:0005751 | mitochondrial respiratory chain complex IV(GO:0005751) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 72.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.4 | 61.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.6 | 51.1 | GO:0003684 | damaged DNA binding(GO:0003684) |
| 0.6 | 42.1 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 10.0 | 40.0 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 2.1 | 33.8 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 1.1 | 32.9 | GO:0015002 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 1.4 | 30.2 | GO:0052629 | phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629) |
| 0.6 | 30.0 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 3.1 | 24.7 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 85.1 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.3 | 39.1 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.6 | 32.0 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.8 | 31.2 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.6 | 20.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.5 | 18.6 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.2 | 18.0 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.3 | 17.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 16.2 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.4 | 15.2 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 68.4 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 0.7 | 56.1 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.8 | 41.6 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.9 | 40.0 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 2.6 | 39.3 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 2.3 | 37.5 | REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the late endosome membrane |
| 0.2 | 34.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.9 | 32.7 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.9 | 32.1 | REACTOME ELONGATION ARREST AND RECOVERY | Genes involved in Elongation arrest and recovery |
| 0.2 | 26.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |