ISMARA results: HOXA1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXA1

Z-value: 1.15

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Transcription factors associated with HOXA1

Gene Symbol	Gene ID	Gene Info
HOXA1 Ensembl NCBI GeneCards UniProt	ENSG00000105991.10	HOXA1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXA1	hg38_v1_chr7_-_27095972_27096039	-0.12	9.0e-02	Click!

Activity profile of HOXA1 motif

Sorted Z-values of HOXA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA1

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Top targets:

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Promoter	Score	Transcript	Gene	Gene Info
chr8_+_103140692 Show fit	56.49	ENST00000438105.2 ENST00000309982.10 ENST00000297574.6	BAALC Ensembl NCBI GeneCards UniProt Show fit	BAALC binder of MAP3K1 and KLF4
chr20_-_23637933 Show fit	39.95	ENST00000398411.5	CST3 Ensembl NCBI GeneCards UniProt Show fit	cystatin C
chr16_+_83968244 Show fit	34.18	ENST00000305202.9	NECAB2 Ensembl NCBI GeneCards UniProt Show fit	N-terminal EF-hand calcium binding protein 2
chr20_-_23637947 Show fit	33.11	ENST00000376925.8	CST3 Ensembl NCBI GeneCards UniProt Show fit	cystatin C
chr8_-_27611325 Show fit	27.65	ENST00000523500.5	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr5_-_42825884 Show fit	25.85	ENST00000506577.5	SELENOP Ensembl NCBI GeneCards UniProt Show fit	selenoprotein P
chr17_-_44911281 Show fit	21.83	ENST00000638304.1 ENST00000591880.2 ENST00000586125.2 ENST00000639921.1	GFAP Ensembl NCBI GeneCards UniProt Show fit	glial fibrillary acidic protein
chr8_-_27605271 Show fit	20.52	ENST00000522098.1	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin
chr8_-_27258414 Show fit	19.91	ENST00000523048.5	STMN4 Ensembl NCBI GeneCards UniProt Show fit	stathmin 4
chr8_-_27611424 Show fit	19.68	ENST00000405140.7	CLU Ensembl NCBI GeneCards UniProt Show fit	clusterin

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
14.1	84.5	GO:0060313	negative regulation of blood vessel remodeling(GO:0060313)
13.6	67.9	GO:1902847	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
8.5	34.2	GO:1904021	regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021)
0.7	33.2	GO:0007019	microtubule depolymerization(GO:0007019)
0.2	28.3	GO:0007368	determination of left/right symmetry(GO:0007368)
7.0	28.2	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
3.2	25.9	GO:0001887	selenium compound metabolic process(GO:0001887)
2.5	25.1	GO:0048680	positive regulation of axon regeneration(GO:0048680) negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
2.2	22.0	GO:0036309	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.5	21.8	GO:1904714	regulation of chaperone-mediated autophagy(GO:1904714)

Showing 1 to 10 of 139 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	91.1	GO:0099572	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.0	73.1	GO:0005771	multivesicular body(GO:0005771)
4.5	67.9	GO:0097418	neurofibrillary tangle(GO:0097418)
0.4	54.5	GO:0042734	presynaptic membrane(GO:0042734)
0.2	42.2	GO:0030426	growth cone(GO:0030426)
0.1	40.9	GO:0030424	axon(GO:0030424)
0.3	29.8	GO:0005604	basement membrane(GO:0005604)
0.4	26.3	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
1.3	25.9	GO:0031089	platelet dense granule lumen(GO:0031089)
0.4	22.1	GO:0031430	M band(GO:0031430)

Showing 1 to 10 of 62 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	76.5	GO:0001540	beta-amyloid binding(GO:0001540)
3.0	67.9	GO:0051787	misfolded protein binding(GO:0051787)
11.4	34.2	GO:0031687	A2A adenosine receptor binding(GO:0031687)
0.2	29.1	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
2.8	28.2	GO:0030911	TPR domain binding(GO:0030911)
0.1	27.8	GO:0015631	tubulin binding(GO:0015631)
0.2	26.7	GO:0017048	Rho GTPase binding(GO:0017048)
2.2	25.9	GO:0008430	selenium binding(GO:0008430)
4.2	25.1	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
1.3	24.2	GO:0008179	adenylate cyclase binding(GO:0008179)

Showing 1 to 10 of 112 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	87.3	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.5	67.9	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.7	34.4	PID RAS PATHWAY	Regulation of Ras family activation
0.4	25.6	ST ADRENERGIC	Adrenergic Pathway
0.7	21.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.4	14.5	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.2	14.1	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.3	13.7	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.2	11.4	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	10.2	PID TCPTP PATHWAY	Signaling events mediated by TCPTP

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	75.3	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
1.4	64.4	REACTOME AMYLOIDS	Genes involved in Amyloids
0.6	26.8	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.3	21.8	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.8	17.9	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.4	17.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
1.4	16.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.6	13.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.2	11.4	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.2	10.1	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK

Showing 1 to 10 of 47 entries

Results for HOXA1

Z-value: 1.15

Motif logo

Transcription factors associated with HOXA1

Activity-expression correlation:

Activity profile of HOXA1 motif

Sorted Z-values of HOXA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: