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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXA10_HOXB9
Z-value: 0.68
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Transcription factors associated with HOXA10_HOXB9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB9 | hg38_v1_chr17_-_48626325_48626379 | -0.27 | 5.0e-05 | Click! |
| HOXA10 | hg38_v1_chr7_-_27174274_27174335, hg38_v1_chr7_-_27174253_27174267 | -0.13 | 5.0e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA10_HOXB9
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 15.2 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 1.7 | 10.3 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.2 | 10.1 | GO:0046677 | response to antibiotic(GO:0046677) |
| 1.6 | 9.8 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.4 | 9.5 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.4 | 7.9 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 1.1 | 6.7 | GO:0097338 | response to clozapine(GO:0097338) |
| 2.1 | 6.3 | GO:0061011 | hepatic duct development(GO:0061011) |
| 0.3 | 5.8 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.4 | 5.7 | GO:0001778 | plasma membrane repair(GO:0001778) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 12.4 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.8 | 10.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.5 | 9.8 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 9.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.8 | 7.6 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.3 | 6.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 6.2 | GO:0016607 | nuclear speck(GO:0016607) |
| 1.1 | 5.7 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 4.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 4.5 | GO:0000790 | nuclear chromatin(GO:0000790) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 15.2 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.4 | 10.3 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.3 | 9.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 8.4 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.8 | 7.6 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.4 | 6.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 6.7 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.3 | 6.3 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 6.1 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 5.6 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 13.8 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 9.8 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 7.9 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 7.1 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 6.9 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 5.9 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.0 | 4.4 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.0 | 3.1 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 2.8 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 10.7 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.4 | 10.3 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 7.0 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 5.8 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.1 | 5.5 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 5.2 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.0 | 4.3 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 4.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.3 | 3.8 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |