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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXA10_HOXB9

Z-value: 0.68

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Transcription factors associated with HOXA10_HOXB9

Gene Symbol Gene ID Gene Info
ENSG00000253293.5 HOXA10
ENSG00000170689.10 HOXB9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB9hg38_v1_chr17_-_48626325_48626379-0.275.0e-05Click!
HOXA10hg38_v1_chr7_-_27174274_27174335,
hg38_v1_chr7_-_27174253_27174267
-0.135.0e-02Click!

Activity profile of HOXA10_HOXB9 motif

Sorted Z-values of HOXA10_HOXB9 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA10_HOXB9

PNG image of the network

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Promoter Score Transcript Gene Gene Info
chr15_-_55249029 10.29 ENST00000566877.5
RAB27A, member RAS oncogene family
chr1_+_84164962 6.66 ENST00000614872.4
ENST00000394839.6
protein kinase cAMP-activated catalytic subunit beta
chr5_+_36608146 5.81 ENST00000381918.4
ENST00000513646.1
solute carrier family 1 member 3
chr6_+_158312459 5.57 ENST00000367097.8
TUB like protein 4
chr3_-_15798184 5.38 ENST00000624145.3
ankyrin repeat domain 28
chr5_+_36606355 5.12 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
solute carrier family 1 member 3
chr12_-_89656051 4.93 ENST00000261173.6
ATPase plasma membrane Ca2+ transporting 1
chr12_-_89656093 4.82 ENST00000359142.7
ATPase plasma membrane Ca2+ transporting 1
chr3_+_158110363 4.46 ENST00000683137.1
arginine and serine rich coiled-coil 1
chr5_+_36596583 4.30 ENST00000680318.1
solute carrier family 1 member 3
chr10_-_72088533 4.24 ENST00000373109.7
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2
chr2_-_51032091 4.08 ENST00000637511.1
ENST00000405472.7
ENST00000405581.3
ENST00000401669.7
neurexin 1
chr14_+_52707178 3.85 ENST00000612399.4
proteasome 26S subunit, ATPase 6
chr6_-_6004040 3.84 ENST00000622188.4
neuritin 1
chr8_+_106726012 3.83 ENST00000449762.6
ENST00000297447.10
oxidation resistance 1
chr1_-_151763334 3.78 ENST00000481777.5
ENST00000368829.3
ENST00000368830.8
mitochondrial ribosomal protein L9
chr15_+_66386902 3.76 ENST00000307102.10
mitogen-activated protein kinase kinase 1
chr3_+_158110052 3.75 ENST00000295930.7
ENST00000471994.5
ENST00000482822.3
ENST00000476899.6
ENST00000683899.1
ENST00000684604.1
ENST00000682164.1
ENST00000464171.5
ENST00000611884.5
ENST00000312179.10
ENST00000475278.6
arginine and serine rich coiled-coil 1
chr10_+_92691813 3.75 ENST00000472590.6
hematopoietically expressed homeobox
chr3_-_18438767 3.73 ENST00000454909.6
SATB homeobox 1
chr14_+_52707192 3.71 ENST00000445930.7
ENST00000555339.5
ENST00000556813.1
proteasome 26S subunit, ATPase 6
chr12_+_78863962 3.64 ENST00000393240.7
synaptotagmin 1
chr6_+_26103922 3.49 ENST00000377803.4
H4 clustered histone 3
chr17_+_50746614 3.45 ENST00000513969.5
ENST00000503728.1
LUC7 like 3 pre-mRNA splicing factor
chr4_-_56656448 3.40 ENST00000553379.6
HOP homeobox
chr18_+_58196736 3.38 ENST00000675221.1
NEDD4 like E3 ubiquitin protein ligase
chr4_-_56656507 3.24 ENST00000381255.7
ENST00000317745.11
ENST00000555760.6
ENST00000556614.6
HOP homeobox
chr11_-_105035113 3.17 ENST00000526568.5
ENST00000531166.5
ENST00000534497.5
ENST00000527979.5
ENST00000533400.6
ENST00000528974.1
ENST00000525825.5
ENST00000353247.9
ENST00000446369.5
ENST00000436863.7
caspase 1
chr7_-_78771265 3.11 ENST00000630991.2
ENST00000629359.2
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr6_+_32844789 2.86 ENST00000414474.5
proteasome 20S subunit beta 9
chr4_-_56681588 2.86 ENST00000554144.5
ENST00000381260.7
HOP homeobox
chr1_+_12464912 2.63 ENST00000543766.2
vacuolar protein sorting 13 homolog D
chr12_+_54498766 2.60 ENST00000545638.2
NCK associated protein 1 like
chrX_-_77634229 2.59 ENST00000675732.1
ATRX chromatin remodeler
chr9_+_131190119 2.58 ENST00000483497.6
nucleoporin 214
chr10_+_92691897 2.54 ENST00000492654.3
hematopoietically expressed homeobox
chr1_+_44405164 2.54 ENST00000355387.6
ring finger protein 220
chr6_+_6588082 2.50 ENST00000379953.6
lymphocyte antigen 86
chr6_-_8102481 2.45 ENST00000502429.5
ENST00000429723.6
ENST00000379715.10
ENST00000507463.1
eukaryotic translation elongation factor 1 epsilon 1
chr5_-_131165272 2.44 ENST00000675491.1
ENST00000506908.2
histidine triad nucleotide binding protein 1
chr5_+_68290637 2.44 ENST00000336483.9
phosphoinositide-3-kinase regulatory subunit 1
chr12_-_49187369 2.43 ENST00000547939.6
tubulin alpha 1a
chr2_+_31234144 2.39 ENST00000322054.10
EH domain containing 3
chr8_+_131939865 2.35 ENST00000520362.5
ENST00000519656.1
EFR3 homolog A
chr5_-_131165231 2.28 ENST00000675100.1
ENST00000304043.10
ENST00000513012.2
histidine triad nucleotide binding protein 1
chr18_-_5396265 2.26 ENST00000579951.2
erythrocyte membrane protein band 4.1 like 3
chr1_+_40738834 2.26 ENST00000525290.5
ENST00000530965.5
ENST00000416859.6
ENST00000308733.9
nuclear transcription factor Y subunit gamma
chr12_+_1691011 2.23 ENST00000357103.5
adiponectin receptor 2
chr9_-_92325322 2.23 ENST00000542613.5
ENST00000542053.5
ENST00000442668.7
ENST00000545558.5
ENST00000432670.6
ENST00000433029.6
ENST00000411621.6
nucleolar protein 8
chr16_+_56191476 2.22 ENST00000262493.12
G protein subunit alpha o1
chr11_-_3379212 2.18 ENST00000429541.6
ENST00000532539.1
ENST00000343338.11
ENST00000620374.4
zinc finger protein 195
chr8_-_80171496 2.18 ENST00000379096.9
ENST00000518937.6
tumor protein D52
chr12_-_118190510 2.17 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAO kinase 3
chr3_-_15797930 2.16 ENST00000683139.1
ankyrin repeat domain 28
chrX_-_123623155 2.11 ENST00000618150.4
THO complex 2
chr10_-_125816510 2.10 ENST00000650587.1
uroporphyrinogen III synthase
chr9_-_92325577 2.09 ENST00000358855.8
ENST00000421075.6
ENST00000536624.5
nucleolar protein 8
chr12_+_54284258 2.09 ENST00000677666.1
heterogeneous nuclear ribonucleoprotein A1
chrX_-_136880715 2.07 ENST00000431446.7
ENST00000320676.11
ENST00000562646.5
RNA binding motif protein X-linked
chr17_-_10549652 2.06 ENST00000245503.10
myosin heavy chain 2
chr17_-_10549612 2.05 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
myosin heavy chain 2
chr4_-_89838289 2.03 ENST00000336904.7
synuclein alpha
chrX_-_123622809 2.02 ENST00000441692.5
THO complex 2
chr6_+_29301701 2.01 ENST00000641895.1
olfactory receptor family 14 subfamily J member 1
chr5_+_136160986 1.92 ENST00000507637.1
SMAD family member 5
chr6_-_69699124 1.91 ENST00000651675.1
LMBR1 domain containing 1
chr7_+_16661182 1.91 ENST00000446596.5
ENST00000452975.6
ENST00000438834.5
basic leucine zipper and W2 domains 2
chr11_-_3379110 1.88 ENST00000005082.13
ENST00000534569.5
ENST00000438262.6
ENST00000528796.5
ENST00000528410.5
ENST00000529678.5
ENST00000618467.4
ENST00000354599.10
ENST00000399602.9
ENST00000526601.5
ENST00000525502.5
ENST00000533036.5
zinc finger protein 195
chr12_-_53677397 1.85 ENST00000338662.6
ENST00000552242.5
ATP synthase membrane subunit c locus 2
chr19_-_29213110 1.84 ENST00000304863.6
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1
chr17_-_31297231 1.78 ENST00000247271.5
oligodendrocyte myelin glycoprotein
chr5_-_88823763 1.77 ENST00000635898.1
ENST00000626391.2
ENST00000628656.2
myocyte enhancer factor 2C
chr5_+_140786136 1.71 ENST00000378133.4
ENST00000504120.4
protocadherin alpha 1
chr2_-_216013582 1.65 ENST00000620139.4
melanoregulin
chr17_-_10549694 1.62 ENST00000622564.4
myosin heavy chain 2
chr19_+_926001 1.60 ENST00000263620.8
AT-rich interaction domain 3A
chr1_-_152414256 1.55 ENST00000271835.3
cornulin
chr14_+_79279403 1.55 ENST00000281127.11
neurexin 3
chr4_+_112647059 1.53 ENST00000511529.1
La ribonucleoprotein 7, transcriptional regulator
chr11_-_102705737 1.50 ENST00000260229.5
matrix metallopeptidase 27
chr2_-_175181663 1.49 ENST00000392541.3
ENST00000284727.9
ENST00000409194.5
ATP synthase membrane subunit c locus 3
chr8_+_2045058 1.49 ENST00000523438.1
myomesin 2
chr12_+_25052634 1.48 ENST00000548766.5
inositol 1,4,5-triphosphate receptor associated 2
chr12_+_20810698 1.48 ENST00000540853.5
ENST00000381545.8
solute carrier organic anion transporter family member 1B3
chr4_+_87975667 1.46 ENST00000237623.11
ENST00000682655.1
ENST00000508233.6
ENST00000360804.4
ENST00000395080.8
secreted phosphoprotein 1
chr4_-_139301204 1.41 ENST00000505036.5
ENST00000539002.5
ENST00000544855.5
NADH:ubiquinone oxidoreductase subunit C1
chr6_+_12717660 1.41 ENST00000674637.1
phosphatase and actin regulator 1
chr5_+_140882116 1.36 ENST00000289272.3
ENST00000409494.5
ENST00000617769.1
protocadherin alpha 13
chr4_-_71784046 1.34 ENST00000513476.5
ENST00000273951.13
GC vitamin D binding protein
chr3_-_139678011 1.34 ENST00000646611.1
ENST00000645290.1
ENST00000647257.1
nicotinamide nucleotide adenylyltransferase 3
chr4_+_67558719 1.32 ENST00000265404.7
ENST00000396225.1
signal transducing adaptor family member 1
chr8_+_2045037 1.31 ENST00000262113.9
myomesin 2
chr3_-_50338226 1.29 ENST00000395126.7
Ras association domain family member 1
chr3_+_42091316 1.28 ENST00000327628.10
trafficking kinesin protein 1
chr6_+_101181254 1.27 ENST00000682090.1
ENST00000421544.6
glutamate ionotropic receptor kainate type subunit 2
chr19_-_4558417 1.26 ENST00000586965.1
semaphorin 6B
chr1_+_220094086 1.25 ENST00000366922.3
isoleucyl-tRNA synthetase 2, mitochondrial
chr20_-_7940444 1.24 ENST00000378789.4
hydroxyacid oxidase 1
chr3_+_138621225 1.23 ENST00000479848.1
Fas apoptotic inhibitory molecule
chr11_-_31810657 1.22 ENST00000379109.7
paired box 6
chr12_+_25052732 1.20 ENST00000547044.5
inositol 1,4,5-triphosphate receptor associated 2
chr11_-_6006946 1.19 ENST00000641156.1
ENST00000641835.1
olfactory receptor family 56 subfamily A member 4
chr1_-_155910881 1.17 ENST00000609492.1
ENST00000368322.7
Ras like without CAAX 1
chr6_+_30328889 1.16 ENST00000396547.5
ENST00000623385.3
tripartite motif containing 39
TRIM39-RPP21 readthrough
chrX_+_37780049 1.13 ENST00000378588.5
cytochrome b-245 beta chain
chr14_-_25010604 1.12 ENST00000550887.5
syntaxin binding protein 6
chr9_+_122941003 1.11 ENST00000373647.9
ENST00000402311.5
RAB GTPase activating protein 1
chr2_-_240820945 1.09 ENST00000428768.2
ENST00000650053.1
ENST00000650130.1
kinesin family member 1A
chr16_-_9943182 1.09 ENST00000535259.6
glutamate ionotropic receptor NMDA type subunit 2A
chr22_-_21938557 1.08 ENST00000424647.1
ENST00000407142.5
protein phosphatase, Mg2+/Mn2+ dependent 1F
chr12_-_81598360 1.07 ENST00000333447.11
ENST00000407050.8
PTPRF interacting protein alpha 2
chr1_+_92168915 1.07 ENST00000637221.2
BTB domain containing 8
chr4_-_86360071 1.07 ENST00000641677.1
ENST00000639234.1
ENST00000641553.1
ENST00000641826.1
ENST00000641537.1
ENST00000395169.9
ENST00000641408.1
ENST00000638225.1
ENST00000641052.1
mitogen-activated protein kinase 10
chr12_-_100092890 1.06 ENST00000550544.5
ENST00000551980.1
ENST00000548045.5
ENST00000545232.6
ENST00000551973.5
UHRF1 binding protein 1 like
chr18_-_55321986 1.05 ENST00000570287.6
transcription factor 4
chr14_+_79279339 1.02 ENST00000557594.5
neurexin 3
chr11_-_31804067 1.01 ENST00000639548.1
ENST00000640125.1
ENST00000481563.6
ENST00000639079.1
ENST00000638762.1
ENST00000638346.1
paired box 6
chr15_-_66386668 1.01 ENST00000568216.5
ENST00000562124.5
ENST00000570251.1
TIMELESS interacting protein
chr18_+_58341038 1.01 ENST00000679791.1
NEDD4 like E3 ubiquitin protein ligase
chr2_+_27217361 0.99 ENST00000264705.9
ENST00000403525.5
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase
chr8_-_103501890 0.99 ENST00000649416.1
novel protein
chr3_+_169911566 0.98 ENST00000428432.6
ENST00000335556.7
sterile alpha motif domain containing 7
chr12_-_62935117 0.97 ENST00000228705.7
protein phosphatase, Mg2+/Mn2+ dependent 1H
chr10_+_89392546 0.97 ENST00000546318.2
ENST00000371804.4
interferon induced protein with tetratricopeptide repeats 1
chr1_+_74235377 0.94 ENST00000326637.8
TNNI3 interacting kinase
chr6_+_44247866 0.89 ENST00000371554.2
heat shock protein 90 alpha family class B member 1
chr10_+_86668501 0.88 ENST00000623056.4
ENST00000263066.11
ENST00000429277.7
ENST00000361373.9
ENST00000372066.8
ENST00000372056.8
ENST00000623007.3
LIM domain binding 3
chr11_-_31810991 0.87 ENST00000640684.1
paired box 6
chr12_+_25052512 0.87 ENST00000557489.5
ENST00000354454.7
ENST00000536173.5
inositol 1,4,5-triphosphate receptor associated 2
chr10_+_100347225 0.86 ENST00000370355.3
stearoyl-CoA desaturase
chr18_-_55402187 0.85 ENST00000630268.2
ENST00000570177.6
transcription factor 4
chr1_-_226739271 0.85 ENST00000429204.6
ENST00000366784.1
inositol-trisphosphate 3-kinase B
chr21_+_33025927 0.84 ENST00000430860.1
ENST00000382357.4
ENST00000333337.3
oligodendrocyte transcription factor 2
chr19_-_48249841 0.84 ENST00000447740.6
caspase recruitment domain family member 8
chr11_-_119101814 0.83 ENST00000682791.1
ENST00000639704.1
ENST00000354202.9
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
chr11_-_31811140 0.82 ENST00000639916.1
paired box 6
chr11_-_31811112 0.81 ENST00000640242.1
ENST00000640613.1
ENST00000606377.7
paired box 6
chr9_-_135961310 0.81 ENST00000371756.4
UBA domain containing 1
chr19_-_3500625 0.81 ENST00000672935.1
deoxyhypusine hydroxylase
chr19_-_3500664 0.81 ENST00000427575.6
deoxyhypusine hydroxylase
chr2_+_161136901 0.81 ENST00000259075.6
ENST00000432002.5
TRAF family member associated NFKB activator
chr18_-_55322215 0.80 ENST00000457482.7
transcription factor 4
chr3_+_112990956 0.76 ENST00000383678.8
ENST00000383677.7
ENST00000619116.4
GTP binding protein 8 (putative)
chr11_-_117316230 0.76 ENST00000313005.11
ENST00000528053.5
beta-secretase 1
chr11_+_10450289 0.75 ENST00000444303.6
adenosine monophosphate deaminase 3
chr11_-_31811034 0.75 ENST00000638250.1
paired box 6
chr19_+_12064720 0.75 ENST00000550826.1
ENST00000439326.8
zinc finger protein 844
chr20_-_51768327 0.74 ENST00000311637.9
ENST00000338821.6
ATPase phospholipid transporting 9A (putative)
chr5_+_72848161 0.73 ENST00000506351.6
transportin 1
chr12_-_81598332 0.72 ENST00000443686.7
PTPRF interacting protein alpha 2
chr21_-_34526850 0.71 ENST00000481448.5
ENST00000381132.6
regulator of calcineurin 1
chr1_+_22052627 0.69 ENST00000400259.5
ENST00000344548.7
ENST00000315554.13
ENST00000656825.1
ENST00000651171.1
ENST00000652582.1
ENST00000667384.1
cell division cycle 42
chr1_+_154429315 0.69 ENST00000476006.5
interleukin 6 receptor
chr1_-_205121964 0.68 ENST00000264515.11
RB binding protein 5, histone lysine methyltransferase complex subunit
chr19_+_21082140 0.66 ENST00000616183.1
ENST00000596053.5
zinc finger protein 714
chr1_+_53014926 0.65 ENST00000430330.6
ENST00000408941.7
ENST00000478274.6
ENST00000484100.5
ENST00000435345.6
ENST00000488965.1
sterol carrier protein 2
chr10_+_94938649 0.65 ENST00000461906.1
ENST00000260682.8
cytochrome P450 family 2 subfamily C member 9
chr4_-_68951763 0.64 ENST00000251566.9
UDP glucuronosyltransferase family 2 member A3
chr1_-_205121986 0.64 ENST00000367164.1
RB binding protein 5, histone lysine methyltransferase complex subunit
chr7_+_74650224 0.62 ENST00000652150.1
ENST00000650807.1
general transcription factor IIi
chr16_+_25111703 0.62 ENST00000380966.8
ENST00000399069.8
leucine carboxyl methyltransferase 1
chr4_+_143433491 0.61 ENST00000512843.1
GRB2 associated binding protein 1
chr13_-_103066411 0.59 ENST00000245312.5
solute carrier family 10 member 2
chr5_-_20575850 0.59 ENST00000507958.5
cadherin 18
chr5_+_72848115 0.58 ENST00000679378.1
transportin 1
chr7_+_80133830 0.57 ENST00000648098.1
ENST00000648476.1
ENST00000648412.1
ENST00000648953.1
ENST00000648306.1
ENST00000648832.1
ENST00000648877.1
ENST00000442586.2
ENST00000649487.1
ENST00000649267.1
G protein subunit alpha i1
chr20_-_8019744 0.57 ENST00000246024.7
thioredoxin related transmembrane protein 4
chr10_-_113854368 0.55 ENST00000369305.1
DNA cross-link repair 1A
chr12_-_70754631 0.54 ENST00000440835.6
ENST00000549308.5
ENST00000550661.1
ENST00000378778.5
protein tyrosine phosphatase receptor type R
chr1_-_48776811 0.53 ENST00000371833.4
BEN domain containing 5
chr13_-_79405784 0.53 ENST00000267229.11
RNA binding motif protein 26
chr3_+_138621207 0.53 ENST00000464668.5
Fas apoptotic inhibitory molecule
chr20_-_35699181 0.53 ENST00000374085.5
ENST00000419569.5
NFS1 cysteine desulfurase
chr5_+_141966820 0.51 ENST00000513019.5
ENST00000394519.5
ENST00000356143.5
ring finger protein 14
chr1_-_161238223 0.51 ENST00000515452.1
nuclear receptor subfamily 1 group I member 3
chr1_-_36149464 0.51 ENST00000373166.8
ENST00000373159.1
ENST00000373162.5
ENST00000616074.4
ENST00000616395.4
trafficking protein particle complex 3
chr16_+_70346856 0.50 ENST00000302243.12
ENST00000417604.6
DEAD-box helicase 19A
chr1_-_7853054 0.49 ENST00000361696.10
urotensin 2
chr10_-_95069489 0.47 ENST00000371270.6
ENST00000535898.5
ENST00000623108.3
cytochrome P450 family 2 subfamily C member 8
chr2_+_108621260 0.46 ENST00000409441.5
LIM zinc finger domain containing 1
chr12_+_55549602 0.46 ENST00000641569.1
ENST00000641851.1
olfactory receptor family 6 subfamily C member 4
chr5_-_111976925 0.40 ENST00000395634.7
neuronal regeneration related protein
chr2_+_108588286 0.40 ENST00000332345.10
LIM zinc finger domain containing 1
chr16_-_21652598 0.40 ENST00000569602.1
ENST00000268389.6
immunoglobulin superfamily member 6
chr10_+_78033760 0.39 ENST00000435275.5
ENST00000613865.5
ENST00000645440.1
ENST00000464716.6
ENST00000360830.9
ENST00000372360.9
ENST00000440692.6
ribosomal protein S24
chr4_-_122456725 0.38 ENST00000226730.5
interleukin 2
chr6_-_109483208 0.37 ENST00000230122.4
zinc finger and BTB domain containing 24
chr12_+_15911324 0.36 ENST00000524480.5
ENST00000428559.7
ENST00000531803.5
ENST00000532964.5
deoxyribose-phosphate aldolase
chr19_+_36100593 0.36 ENST00000680211.1
WD repeat domain 62
chr17_-_35142280 0.34 ENST00000586869.5
ENST00000442241.9
ENST00000360831.9
notchless homolog 1
chr12_-_81758641 0.34 ENST00000552948.5
ENST00000548586.5
PTPRF interacting protein alpha 2
chr13_-_46052712 0.34 ENST00000242848.8
ENST00000679008.1
ENST00000282007.7
zinc finger CCCH-type containing 13
chr3_+_178419123 0.33 ENST00000614557.1
ENST00000455307.5
ENST00000436432.1
potassium large conductance calcium-activated channel, subfamily M, beta member 2 (KCNMB2-IT1 - KCNMB2 readthrough transcript)
long intergenic non-protein coding RNA 1014
chr1_+_153031195 0.33 ENST00000307098.5
small proline rich protein 1B
chr2_+_207559168 0.33 ENST00000448277.5
ENST00000457101.5
cAMP responsive element binding protein 1
chr17_-_10657302 0.32 ENST00000583535.6
myosin heavy chain 3
chr9_+_101185029 0.32 ENST00000395056.2
phospholipid phosphatase related 1
chr3_-_58210961 0.31 ENST00000486455.5
ENST00000394549.7
deoxyribonuclease 1 like 3
chrX_-_81201886 0.30 ENST00000451455.1
ENST00000358130.7
ENST00000436386.5
high mobility group nucleosome binding domain 5
chr11_-_31811231 0.30 ENST00000438681.6
paired box 6

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 6.3 GO:0061011 hepatic duct development(GO:0061011)
1.7 10.3 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.6 9.8 GO:1990034 calcium ion export from cell(GO:1990034)
1.5 15.2 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
1.2 3.6 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
1.1 6.7 GO:0097338 response to clozapine(GO:0097338)
1.1 3.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.9 2.6 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.9 2.6 GO:0034092 negative regulation of maintenance of sister chromatid cohesion(GO:0034092) negative regulation of maintenance of mitotic sister chromatid cohesion(GO:0034183) maintenance of mitotic sister chromatid cohesion, telomeric(GO:0099403) mitotic sister chromatid cohesion, telomeric(GO:0099404) regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904907) negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric(GO:1904908)
0.5 3.8 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.5 2.1 GO:0071418 cellular response to amine stimulus(GO:0071418)
0.5 1.5 GO:2000866 positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866)
0.5 4.3 GO:1902570 protein localization to nucleolus(GO:1902570)
0.4 1.3 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.4 9.5 GO:0001829 trophectodermal cell differentiation(GO:0001829)
0.4 2.1 GO:1903936 cellular response to sodium arsenite(GO:1903936)
0.4 4.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.4 7.9 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.4 5.7 GO:0001778 plasma membrane repair(GO:0001778)
0.4 1.1 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.4 4.1 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.3 2.8 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.3 4.1 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.3 5.8 GO:0003322 pancreatic A cell development(GO:0003322)
0.3 2.0 GO:2000470 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
0.3 1.0 GO:0044205 'de novo' UMP biosynthetic process(GO:0044205)
0.3 1.3 GO:0034628 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process(GO:0034627) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.3 1.0 GO:0051097 negative regulation of helicase activity(GO:0051097)
0.3 1.3 GO:0098957 anterograde axonal transport of mitochondrion(GO:0098957)
0.3 1.9 GO:0001880 Mullerian duct regression(GO:0001880)
0.3 1.9 GO:0038016 insulin receptor internalization(GO:0038016)
0.3 3.1 GO:0003402 planar cell polarity pathway involved in axis elongation(GO:0003402)
0.3 3.7 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.3 0.9 GO:1901388 regulation of transforming growth factor beta activation(GO:1901388) negative regulation of transforming growth factor beta activation(GO:1901389)
0.3 0.8 GO:0021779 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.3 2.2 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.3 2.5 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.3 2.3 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.2 4.2 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.2 0.7 GO:0060661 submandibular salivary gland formation(GO:0060661) hair follicle cell proliferation(GO:0071335) regulation of hair follicle cell proliferation(GO:0071336) positive regulation of hair follicle cell proliferation(GO:0071338)
0.2 1.8 GO:0003172 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2 1.1 GO:0033058 directional locomotion(GO:0033058)
0.2 3.8 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.2 2.4 GO:1903358 Golgi to lysosome transport(GO:0090160) regulation of Golgi organization(GO:1903358)
0.2 2.5 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.2 0.5 GO:0018282 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.2 2.5 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.2 0.7 GO:0002384 hepatic immune response(GO:0002384)
0.2 0.8 GO:0019348 dolichol metabolic process(GO:0019348)
0.2 1.2 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 10.1 GO:0046677 response to antibiotic(GO:0046677)
0.1 1.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 2.4 GO:0051531 NFAT protein import into nucleus(GO:0051531) positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.1 0.5 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.1 0.8 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1 0.7 GO:0032383 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1 0.8 GO:0006196 AMP catabolic process(GO:0006196)
0.1 0.6 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 1.1 GO:0097267 omega-hydroxylase P450 pathway(GO:0097267)
0.1 0.5 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
0.1 0.8 GO:0033029 neutrophil apoptotic process(GO:0001781) regulation of neutrophil apoptotic process(GO:0033029)
0.1 0.4 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.1 1.1 GO:0051601 exocyst localization(GO:0051601)
0.1 2.6 GO:0007158 neuron cell-cell adhesion(GO:0007158) positive regulation of synapse maturation(GO:0090129)
0.1 5.6 GO:0061512 protein localization to cilium(GO:0061512)
0.1 0.8 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 0.3 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.1 0.3 GO:0070857 regulation of bile acid biosynthetic process(GO:0070857)
0.1 1.3 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 1.3 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 1.1 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.1 2.2 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 2.1 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.1 0.3 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.1 4.7 GO:0050850 positive regulation of calcium-mediated signaling(GO:0050850)
0.1 3.4 GO:0006376 mRNA splice site selection(GO:0006376)
0.1 0.4 GO:2000320 T cell homeostatic proliferation(GO:0001777) regulation of T cell homeostatic proliferation(GO:0046013) negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 1.1 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.1 1.0 GO:0031573 DNA replication checkpoint(GO:0000076) intra-S DNA damage checkpoint(GO:0031573)
0.1 1.2 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.1 2.3 GO:0015721 bile acid and bile salt transport(GO:0015721)
0.1 2.6 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.1 1.6 GO:0032402 melanosome transport(GO:0032402)
0.1 0.5 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.1 1.3 GO:0042359 vitamin D metabolic process(GO:0042359)
0.0 3.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 4.0 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0 0.9 GO:0086069 bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0 0.2 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.2 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.6 GO:1904322 response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0 0.7 GO:0070884 regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0 0.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 3.1 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 2.5 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 1.1 GO:0008089 anterograde axonal transport(GO:0008089)
0.0 1.6 GO:0014072 response to isoquinoline alkaloid(GO:0014072) response to morphine(GO:0043278)
0.0 2.4 GO:0014047 glutamate secretion(GO:0014047)
0.0 3.0 GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479)
0.0 0.1 GO:0050720 interleukin-1 beta biosynthetic process(GO:0050720)
0.0 0.6 GO:0035728 response to hepatocyte growth factor(GO:0035728)
0.0 0.7 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 0.4 GO:0098534 centriole replication(GO:0007099) centriole assembly(GO:0098534)
0.0 0.2 GO:0090308 regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0 1.8 GO:0050771 negative regulation of axonogenesis(GO:0050771)
0.0 1.6 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.0 0.1 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0 1.4 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.3 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.0 1.6 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0 1.2 GO:0045214 sarcomere organization(GO:0045214)
0.0 0.2 GO:0007379 segment specification(GO:0007379)
0.0 0.3 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 0.1 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.4 GO:0052695 cellular glucuronidation(GO:0052695)
0.0 3.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 1.9 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.8 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 1.0 GO:1902017 regulation of cilium assembly(GO:1902017)
0.0 1.9 GO:0030183 B cell differentiation(GO:0030183)
0.0 0.8 GO:1901224 positive regulation of NIK/NF-kappaB signaling(GO:1901224)
0.0 2.4 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.5 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.0 0.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 1.4 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.0 1.6 GO:0009408 response to heat(GO:0009408)
0.0 0.1 GO:0051775 response to redox state(GO:0051775)
0.0 0.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 5.7 GO:0005826 actomyosin contractile ring(GO:0005826)
1.1 3.2 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.9 2.6 GO:0031933 telomeric heterochromatin(GO:0031933)
0.8 10.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.8 7.6 GO:0031595 nuclear proteasome complex(GO:0031595)
0.7 3.6 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.6 2.6 GO:1990876 cytoplasmic side of nuclear pore(GO:1990876)
0.6 2.4 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.5 9.8 GO:0032591 dendritic spine membrane(GO:0032591)
0.5 4.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.4 2.9 GO:1990111 spermatoproteasome complex(GO:1990111)
0.4 2.5 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.4 2.4 GO:0020018 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.3 6.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.3 0.9 GO:1990917 sperm head plasma membrane(GO:1990913) ooplasm(GO:1990917)
0.3 2.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.3 0.8 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.2 3.1 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.2 1.5 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.2 2.6 GO:0031209 SCAR complex(GO:0031209)
0.2 2.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.2 3.4 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 1.8 GO:0045275 mitochondrial respiratory chain complex III(GO:0005750) mitochondrial respiratory chain complex IV(GO:0005751) respiratory chain complex III(GO:0045275)
0.1 0.8 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 0.7 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.1 3.1 GO:0032982 myosin filament(GO:0032982)
0.1 1.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 2.3 GO:0033270 paranode region of axon(GO:0033270)
0.1 1.0 GO:0031298 replication fork protection complex(GO:0031298)
0.1 3.7 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 3.8 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 0.7 GO:0000322 storage vacuole(GO:0000322)
0.1 1.1 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 1.1 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 1.1 GO:0000145 exocyst(GO:0000145)
0.1 0.3 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 1.3 GO:0071141 SMAD protein complex(GO:0071141)
0.1 0.2 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 3.4 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.1 4.7 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 9.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 4.1 GO:0042734 presynaptic membrane(GO:0042734)
0.0 2.4 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.5 GO:0030008 TRAPP complex(GO:0030008)
0.0 2.5 GO:0005771 multivesicular body(GO:0005771)
0.0 2.4 GO:1904115 axon cytoplasm(GO:1904115)
0.0 2.4 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 1.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.9 GO:0031143 pseudopodium(GO:0031143)
0.0 1.7 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 1.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 12.4 GO:0043025 neuronal cell body(GO:0043025)
0.0 0.4 GO:0005682 U5 snRNP(GO:0005682)
0.0 1.2 GO:0030672 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 4.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 6.2 GO:0016607 nuclear speck(GO:0016607)
0.0 2.6 GO:0005770 late endosome(GO:0005770)
0.0 2.2 GO:0098793 presynapse(GO:0098793)
0.0 1.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 1.3 GO:0034399 nuclear periphery(GO:0034399)
0.0 1.0 GO:0043657 host(GO:0018995) host cell(GO:0043657)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 15.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.9 2.6 GO:0015616 DNA translocase activity(GO:0015616)
0.8 7.6 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.7 2.2 GO:0055100 adiponectin binding(GO:0055100)
0.7 3.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.5 2.1 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.4 1.3 GO:1902271 D3 vitamins binding(GO:1902271)
0.4 1.7 GO:0061752 telomeric repeat-containing RNA binding(GO:0061752)
0.4 6.7 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.4 1.2 GO:0052854 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.4 10.3 GO:0031489 myosin V binding(GO:0031489)
0.3 2.8 GO:0070699 type II activin receptor binding(GO:0070699)
0.3 2.0 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.3 9.8 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.3 4.0 GO:0050700 CARD domain binding(GO:0050700)
0.3 6.3 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.3 1.3 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.3 0.9 GO:0002135 CTP binding(GO:0002135)
0.3 2.4 GO:0046935 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.3 1.3 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.2 1.0 GO:0004088 carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.2 1.9 GO:0015235 cobalamin transporter activity(GO:0015235)
0.2 6.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.2 0.7 GO:0032427 GBD domain binding(GO:0032427)
0.2 1.8 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 0.7 GO:0070119 ciliary neurotrophic factor binding(GO:0070119)
0.2 1.1 GO:0034875 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.2 0.7 GO:0070538 oleic acid binding(GO:0070538)
0.2 0.9 GO:0016215 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.2 1.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.2 0.8 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.2 4.2 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 0.8 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.2 4.4 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.2 2.8 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 2.6 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 1.2 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.2 3.7 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.1 0.6 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 1.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.1 1.3 GO:0005549 odorant binding(GO:0005549)
0.1 0.8 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.1 5.4 GO:0000146 microfilament motor activity(GO:0000146)
0.1 2.7 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1 1.7 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.1 0.6 GO:0051998 carboxyl-O-methyltransferase activity(GO:0010340) protein carboxyl O-methyltransferase activity(GO:0051998)
0.1 0.8 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.1 1.1 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 4.4 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 0.7 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1 1.8 GO:0003680 AT DNA binding(GO:0003680)
0.1 2.9 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 6.1 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 1.3 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 0.9 GO:0031013 troponin I binding(GO:0031013)
0.1 0.8 GO:0003876 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 0.2 GO:0003826 alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863)
0.1 1.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 1.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 0.4 GO:0043208 glycosphingolipid binding(GO:0043208)
0.1 0.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.1 4.7 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.3 GO:0050811 GABA receptor binding(GO:0050811)
0.1 0.5 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1 1.1 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.6 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 1.1 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 1.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0051373 protein phosphatase 2B binding(GO:0030346) FATZ binding(GO:0051373)
0.0 0.5 GO:0016783 sulfurtransferase activity(GO:0016783)
0.0 1.4 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 1.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 1.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 8.4 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.7 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.4 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.0 5.6 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.3 GO:0008195 phosphatidate phosphatase activity(GO:0008195) lipid phosphatase activity(GO:0042577)
0.0 3.7 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 3.5 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.6 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.5 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.5 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.0 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.0 1.6 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 1.7 GO:0004497 monooxygenase activity(GO:0004497)
0.0 1.6 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.1 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.3 GO:0005537 mannose binding(GO:0005537)
0.0 0.4 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 0.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.0 0.6 GO:0016303 1-phosphatidylinositol-3-kinase activity(GO:0016303)
0.0 0.5 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 6.9 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 13.8 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 7.1 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 1.9 PID ALK2 PATHWAY ALK2 signaling events
0.1 2.8 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 7.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 2.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 2.0 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 0.8 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.1 9.8 PID CMYB PATHWAY C-MYB transcription factor network
0.1 0.7 ST STAT3 PATHWAY STAT3 Pathway
0.1 5.9 PID CDC42 PATHWAY CDC42 signaling events
0.0 2.0 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 1.1 PID REELIN PATHWAY Reelin signaling pathway
0.0 1.1 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
0.0 4.4 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 3.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.8 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 1.3 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 2.5 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.3 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.0 PID ATR PATHWAY ATR signaling pathway
0.0 0.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 1.0 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 0.8 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.3 2.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.3 3.8 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 4.1 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.2 7.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.2 3.6 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.2 14.3 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.2 5.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 10.7 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.1 5.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 1.2 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.1 2.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 1.3 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation
0.1 2.6 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.1 5.2 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 2.8 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.1 1.3 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.1 1.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.1 1.8 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 1.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 0.9 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0 2.0 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.7 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 1.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 3.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.6 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0 3.1 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.8 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 2.2 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.1 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.0 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.0 4.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.6 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.6 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.0 1.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.5 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 0.8 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 1.7 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 1.8 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 1.3 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions