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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXA2_HOXB1
Z-value: 0.80
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Transcription factors associated with HOXA2_HOXB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB1 | hg38_v1_chr17_-_48530910_48531026 | 0.48 | 3.3e-14 | Click! |
| HOXA2 | hg38_v1_chr7_-_27102669_27102691 | 0.42 | 9.8e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA2_HOXB1
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_+_151239951 Show fit | 19.81 |
ENST00000402676.7
|
A-kinase anchoring protein 12 |
|
| chrX_-_13817346 Show fit | 16.48 |
ENST00000356942.9
|
glycoprotein M6B |
|
| chr11_-_111911759 Show fit | 16.30 |
ENST00000650687.2
|
crystallin alpha B |
|
| chr6_+_151240368 Show fit | 16.04 |
ENST00000253332.5
|
A-kinase anchoring protein 12 |
|
| chr14_-_21048431 Show fit | 15.86 |
ENST00000555026.5
|
NDRG family member 2 |
|
| chr4_-_89836213 Show fit | 14.98 |
ENST00000618500.4
ENST00000508895.5 |
synuclein alpha |
|
| chrX_-_13817027 Show fit | 12.26 |
ENST00000493677.5
ENST00000355135.6 ENST00000316715.9 |
glycoprotein M6B |
|
| chr16_+_7510102 Show fit | 10.90 |
ENST00000682918.1
ENST00000683326.1 ENST00000570626.2 |
RNA binding fox-1 homolog 1 |
|
| chr4_-_89835617 Show fit | 10.38 |
ENST00000611107.1
ENST00000345009.8 ENST00000505199.5 ENST00000502987.5 |
synuclein alpha |
|
| chr7_+_86643902 Show fit | 10.10 |
ENST00000361669.7
|
glutamate metabotropic receptor 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 54.1 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 3.0 | 35.9 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 1.0 | 16.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.9 | 15.9 | GO:0090361 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.8 | 14.4 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.2 | 12.7 | GO:1901385 | regulation of voltage-gated calcium channel activity(GO:1901385) |
| 0.9 | 9.3 | GO:0035865 | cellular response to potassium ion(GO:0035865) |
| 0.1 | 9.2 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 2.3 | 9.0 | GO:1990928 | response to amino acid starvation(GO:1990928) |
| 1.5 | 9.0 | GO:0060529 | squamous basal epithelial stem cell differentiation involved in prostate gland acinus development(GO:0060529) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 46.8 | GO:0005938 | cell cortex(GO:0005938) |
| 0.1 | 42.2 | GO:0045121 | membrane raft(GO:0045121) |
| 0.7 | 25.4 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 1.0 | 16.3 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 15.9 | GO:0030426 | growth cone(GO:0030426) |
| 0.2 | 15.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 14.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 12.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.0 | 11.9 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 10.2 | GO:0005759 | mitochondrial matrix(GO:0005759) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 35.9 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 4.2 | 25.4 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.5 | 16.3 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 15.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.5 | 15.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 3.4 | 10.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 0.1 | 10.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 9.9 | GO:0005179 | hormone activity(GO:0005179) |
| 0.0 | 9.8 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 3.1 | 9.3 | GO:0047783 | steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 25.4 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 15.9 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.2 | 12.1 | PID PI3K PLC TRK PATHWAY | Trk receptor signaling mediated by PI3K and PLC-gamma |
| 0.1 | 9.0 | PID TCPTP PATHWAY | Signaling events mediated by TCPTP |
| 0.1 | 9.0 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 8.4 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 7.4 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.1 | 6.8 | PID ENDOTHELIN PATHWAY | Endothelins |
| 0.1 | 6.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.0 | 6.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 25.4 | REACTOME AMYLOIDS | Genes involved in Amyloids |
| 0.7 | 14.4 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 13.7 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.1 | 12.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.6 | 11.6 | REACTOME ENDOGENOUS STEROLS | Genes involved in Endogenous sterols |
| 0.1 | 9.2 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.4 | 9.0 | REACTOME FGFR2C LIGAND BINDING AND ACTIVATION | Genes involved in FGFR2c ligand binding and activation |
| 0.0 | 7.7 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 7.5 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 0.2 | 6.4 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |