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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXA5
Z-value: 0.47
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Transcription factors associated with HOXA5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA5 | hg38_v1_chr7_-_27143672_27143719 | -0.29 | 1.1e-05 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA5
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.5 | 17.9 | GO:1902938 | regulation of intracellular calcium activated chloride channel activity(GO:1902938) neuron projection maintenance(GO:1990535) |
| 1.7 | 8.7 | GO:0001971 | negative regulation of activation of membrane attack complex(GO:0001971) |
| 0.1 | 7.9 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
| 0.2 | 7.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.2 | 6.0 | GO:0042744 | hydrogen peroxide catabolic process(GO:0042744) |
| 1.3 | 5.1 | GO:0000961 | negative regulation of mitochondrial RNA catabolic process(GO:0000961) |
| 0.7 | 4.3 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.0 | 3.8 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.6 | 3.6 | GO:0032468 | Golgi calcium ion homeostasis(GO:0032468) |
| 0.4 | 3.4 | GO:0071578 | zinc II ion transmembrane import(GO:0071578) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 26.6 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 6.5 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 6.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.2 | 4.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 4.3 | GO:0036126 | sperm flagellum(GO:0036126) |
| 0.0 | 3.6 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.3 | 3.4 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 3.4 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.2 | 3.0 | GO:0044615 | nuclear pore nuclear basket(GO:0044615) |
| 0.7 | 2.9 | GO:0005715 | late recombination nodule(GO:0005715) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 17.9 | GO:1903135 | cupric ion binding(GO:1903135) |
| 0.0 | 9.2 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.3 | 8.7 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 7.7 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.2 | 7.5 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.7 | 6.0 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.3 | 4.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 3.6 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.2 | 3.4 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 3.4 | GO:0035064 | methylated histone binding(GO:0035064) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 17.9 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.2 | 10.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 7.0 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 6.0 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.1 | 4.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.0 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.0 | 2.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 2.6 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.2 | 2.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 1.7 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.2 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 7.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 4.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 3.6 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 3.4 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.2 | 3.4 | REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP | Genes involved in Destabilization of mRNA by Tristetraprolin (TTP) |
| 0.0 | 3.4 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 3.0 | REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN | Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein |
| 0.1 | 2.9 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.1 | 2.9 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |