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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXA6
Z-value: 0.67
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Transcription factors associated with HOXA6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA6 | hg38_v1_chr7_-_27147774_27147774 | 0.38 | 9.3e-09 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA6
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_41194741 Show fit | 12.53 |
ENST00000643541.1
ENST00000426215.5 ENST00000645210.1 ENST00000646381.1 ENST00000405570.6 ENST00000642248.1 ENST00000433400.6 |
catenin beta 1 |
|
| chr12_-_91182652 Show fit | 12.11 |
ENST00000552145.5
ENST00000546745.5 |
decorin |
|
| chr12_-_16608183 Show fit | 11.04 |
ENST00000354662.5
ENST00000538051.5 |
LIM domain only 3 |
|
| chr12_-_91182784 Show fit | 10.87 |
ENST00000547568.6
ENST00000052754.10 ENST00000552962.5 |
decorin |
|
| chr12_-_16608073 Show fit | 10.47 |
ENST00000441439.6
|
LIM domain only 3 |
|
| chr5_-_88883701 Show fit | 9.02 |
ENST00000636998.1
|
myocyte enhancer factor 2C |
|
| chr17_-_55511434 Show fit | 8.70 |
ENST00000636752.1
|
small integral membrane protein 36 |
|
| chr7_-_126533850 Show fit | 8.01 |
ENST00000444921.3
|
glutamate metabotropic receptor 8 |
|
| chr4_-_173530219 Show fit | 7.76 |
ENST00000359562.4
|
heart and neural crest derivatives expressed 2 |
|
| chr12_-_16605939 Show fit | 7.36 |
ENST00000541295.5
ENST00000535535.5 |
LIM domain only 3 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.7 | 39.9 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.1 | 36.2 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 1.8 | 23.0 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.8 | 20.6 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 2.5 | 20.0 | GO:0003172 | primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185) |
| 0.6 | 13.6 | GO:0035855 | megakaryocyte development(GO:0035855) |
| 4.2 | 12.6 | GO:0022012 | subpallium cell proliferation in forebrain(GO:0022012) lateral ganglionic eminence cell proliferation(GO:0022018) lambdoid suture morphogenesis(GO:0060366) sagittal suture morphogenesis(GO:0060367) anterior semicircular canal development(GO:0060873) lateral semicircular canal development(GO:0060875) |
| 2.5 | 12.5 | GO:0007403 | glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793) |
| 0.3 | 12.1 | GO:0048665 | neuron fate specification(GO:0048665) |
| 0.4 | 9.4 | GO:0051934 | dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934) catecholamine uptake(GO:0090493) dopamine uptake(GO:0090494) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 35.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 1.8 | 23.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.5 | 21.3 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.1 | 17.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 16.6 | GO:0098794 | postsynapse(GO:0098794) |
| 0.3 | 12.6 | GO:0016592 | mediator complex(GO:0016592) |
| 2.1 | 12.5 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.0 | 8.7 | GO:0045121 | membrane raft(GO:0045121) |
| 0.1 | 8.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 7.9 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 36.2 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.6 | 27.7 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.3 | 23.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.7 | 12.5 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 2.3 | 9.4 | GO:0005334 | norepinephrine:sodium symporter activity(GO:0005334) |
| 0.9 | 9.4 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.4 | 9.1 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.1 | 9.1 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.5 | 8.1 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
| 0.2 | 8.0 | GO:0008066 | glutamate receptor activity(GO:0008066) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 36.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.5 | 24.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.3 | 20.0 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 0.2 | 13.3 | PID HEDGEHOG GLI PATHWAY | Hedgehog signaling events mediated by Gli proteins |
| 0.4 | 12.5 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 6.6 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.1 | 5.2 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.0 | 5.0 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 4.7 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 4.2 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 66.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.9 | 23.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.6 | 21.3 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.3 | 8.1 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.4 | 8.0 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.0 | 7.1 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |
| 0.1 | 7.0 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 4.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 4.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.2 | 4.2 | REACTOME DESTABILIZATION OF MRNA BY BRF1 | Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1) |