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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXA9
Z-value: 0.75
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Transcription factors associated with HOXA9
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA9 | hg38_v1_chr7_-_27165517_27165545 | 0.03 | 6.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXA9
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_-_13817346 Show fit | 20.53 |
ENST00000356942.9
|
glycoprotein M6B |
|
| chrX_-_13817027 Show fit | 13.95 |
ENST00000493677.5
ENST00000355135.6 ENST00000316715.9 |
glycoprotein M6B |
|
| chr3_-_195583931 Show fit | 10.99 |
ENST00000343267.8
ENST00000421243.5 ENST00000453131.1 |
apolipoprotein D |
|
| chr2_+_20447065 Show fit | 10.55 |
ENST00000272233.6
|
ras homolog family member B |
|
| chr3_-_58627596 Show fit | 9.40 |
ENST00000474531.5
ENST00000465970.1 |
family with sequence similarity 107 member A |
|
| chr2_+_112275588 Show fit | 9.40 |
ENST00000409871.6
ENST00000343936.4 |
zinc finger CCCH-type containing 6 |
|
| chr8_+_79611036 Show fit | 8.69 |
ENST00000220876.12
ENST00000518111.5 |
stathmin 2 |
|
| chr2_-_223602284 Show fit | 7.70 |
ENST00000421386.1
ENST00000305409.3 ENST00000433889.1 |
secretogranin II |
|
| chr14_+_92323154 Show fit | 7.05 |
ENST00000532405.6
ENST00000676001.1 ENST00000531433.5 |
solute carrier family 24 member 4 |
|
| chr3_+_41200104 Show fit | 6.89 |
ENST00000643297.1
ENST00000450969.6 |
catenin beta 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 34.5 | GO:0051581 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 3.7 | 11.0 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 0.3 | 10.2 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 0.9 | 9.5 | GO:0043152 | induction of bacterial agglutination(GO:0043152) |
| 0.3 | 9.3 | GO:0006825 | copper ion transport(GO:0006825) |
| 2.2 | 8.7 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.6 | 7.7 | GO:0048245 | eosinophil chemotaxis(GO:0048245) |
| 0.8 | 7.6 | GO:0036309 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 0.3 | 7.5 | GO:0061154 | endothelial tube morphogenesis(GO:0061154) |
| 0.4 | 7.1 | GO:0097186 | amelogenesis(GO:0097186) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 54.2 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.1 | 25.5 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 24.9 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 16.3 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 11.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.6 | 10.5 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.1 | 10.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 8.9 | GO:0043034 | costamere(GO:0043034) |
| 0.4 | 7.7 | GO:0031045 | dense core granule(GO:0031045) |
| 0.0 | 7.3 | GO:0016324 | apical plasma membrane(GO:0016324) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.8 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.1 | 14.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 10.7 | GO:0030507 | spectrin binding(GO:0030507) |
| 3.2 | 9.5 | GO:0035375 | zymogen binding(GO:0035375) |
| 0.1 | 9.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 1.0 | 8.3 | GO:0004322 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.2 | 7.8 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 0.2 | 7.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 7.4 | GO:0005516 | calmodulin binding(GO:0005516) |
| 1.2 | 7.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.1 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 9.5 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 6.9 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 6.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 6.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 6.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 6.0 | PID RHODOPSIN PATHWAY | Visual signal transduction: Rods |
| 0.1 | 5.8 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.2 | 4.1 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.0 | 3.7 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 10.6 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.4 | 9.7 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.0 | 9.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.2 | 6.9 | REACTOME CTNNB1 PHOSPHORYLATION CASCADE | Genes involved in Beta-catenin phosphorylation cascade |
| 0.1 | 6.8 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 6.3 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.2 | 6.1 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.2 | 5.8 | REACTOME REGULATION OF IFNA SIGNALING | Genes involved in Regulation of IFNA signaling |
| 0.1 | 5.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 5.6 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |