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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXB13
Z-value: 0.37
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Transcription factors associated with HOXB13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB13 | hg38_v1_chr17_-_48728705_48728756 | -0.01 | 9.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB13
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.2 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.0 | 8.0 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 1.3 | 7.7 | GO:0097338 | response to clozapine(GO:0097338) |
| 1.4 | 7.0 | GO:2000542 | negative regulation of gastrulation(GO:2000542) |
| 1.7 | 5.0 | GO:0036292 | DNA rewinding(GO:0036292) |
| 0.6 | 3.4 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.3 | 3.1 | GO:0031666 | positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666) |
| 0.0 | 2.8 | GO:0070527 | platelet aggregation(GO:0070527) |
| 0.2 | 2.3 | GO:1901898 | negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.1 | 2.1 | GO:1903861 | positive regulation of dendrite extension(GO:1903861) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.0 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.0 | 8.0 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.4 | 7.7 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 2.3 | 7.0 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.8 | 5.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.3 | 3.4 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.0 | 3.0 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 2.3 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 2.2 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 1.7 | GO:0044300 | cerebellar mossy fiber(GO:0044300) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 9.2 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.4 | 8.0 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.5 | 7.7 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 7.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.0 | 5.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 3.4 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.0 | 3.0 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.1 | 2.3 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 2.1 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 1.4 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 7.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 7.0 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.0 | 5.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.0 | 1.7 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.1 | 1.4 | PID ALK2 PATHWAY | ALK2 signaling events |
| 0.0 | 1.0 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.1 | 8.0 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.2 | 7.7 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 7.0 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 4.7 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.1 | 3.4 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 3.1 | REACTOME TOLL RECEPTOR CASCADES | Genes involved in Toll Receptor Cascades |
| 0.0 | 3.0 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 2.3 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 1.7 | REACTOME RNA POL III TRANSCRIPTION TERMINATION | Genes involved in RNA Polymerase III Transcription Termination |