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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXB2_UNCX_HOXD3
Z-value: 0.82
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Transcription factors associated with HOXB2_UNCX_HOXD3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD3 | hg38_v1_chr2_+_176157293_176157332 | -0.37 | 2.5e-08 | Click! |
| HOXB2 | hg38_v1_chr17_-_48545077_48545117 | 0.04 | 5.2e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB2_UNCX_HOXD3
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 42.8 | GO:1903435 | positive regulation of constitutive secretory pathway(GO:1903435) |
| 0.8 | 36.2 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.2 | 28.1 | GO:0006414 | translational elongation(GO:0006414) |
| 0.2 | 27.8 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.9 | 26.4 | GO:0097340 | inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) |
| 0.3 | 26.1 | GO:0002479 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent(GO:0002479) |
| 0.1 | 23.8 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 0.9 | 23.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.2 | 22.6 | GO:0045047 | protein targeting to ER(GO:0045047) |
| 4.7 | 18.6 | GO:0007113 | endomitotic cell cycle(GO:0007113) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 62.9 | GO:0045009 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.1 | 38.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.1 | 29.2 | GO:0030529 | intracellular ribonucleoprotein complex(GO:0030529) |
| 0.1 | 26.8 | GO:0098791 | Golgi subcompartment(GO:0098791) |
| 0.3 | 20.7 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.2 | 19.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 19.0 | GO:0005769 | early endosome(GO:0005769) |
| 1.7 | 18.3 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 1.0 | 17.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.5 | 16.7 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 40.8 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.8 | 36.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.8 | 31.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 26.8 | GO:0001047 | core promoter binding(GO:0001047) |
| 0.6 | 26.3 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 25.9 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.6 | 22.0 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 1.9 | 18.8 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 2.7 | 18.6 | GO:0019788 | NEDD8 transferase activity(GO:0019788) |
| 0.1 | 18.1 | GO:0003823 | antigen binding(GO:0003823) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 43.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.3 | 34.5 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.6 | 30.7 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.6 | 22.7 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.5 | 22.7 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 20.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.5 | 19.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.4 | 19.1 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.7 | 18.6 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.7 | 17.6 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 54.5 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.2 | 53.1 | REACTOME TRANSLATION | Genes involved in Translation |
| 0.5 | 47.2 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 1.6 | 38.8 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.2 | 36.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.2 | 33.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.2 | 20.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.8 | 18.3 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.5 | 17.3 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 0.9 | 17.1 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |