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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXB3
Z-value: 0.74
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Transcription factors associated with HOXB3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB3 | hg38_v1_chr17_-_48590231_48590258 | 0.43 | 2.4e-11 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB3
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_25160631 Show fit | 17.11 |
ENST00000510415.1
ENST00000507794.2 ENST00000512921.4 |
SEPSECS antisense RNA 1 (head to head) phosphatidylinositol 4-kinase type 2 beta |
|
| chr8_-_30812867 Show fit | 9.79 |
ENST00000518243.5
|
protein phosphatase 2 catalytic subunit beta |
|
| chr5_+_36608146 Show fit | 9.05 |
ENST00000381918.4
ENST00000513646.1 |
solute carrier family 1 member 3 |
|
| chrX_-_13817027 Show fit | 8.67 |
ENST00000493677.5
ENST00000355135.6 ENST00000316715.9 |
glycoprotein M6B |
|
| chr4_+_112860981 Show fit | 7.18 |
ENST00000671704.1
|
ankyrin 2 |
|
| chr1_-_230745574 Show fit | 6.97 |
ENST00000681269.1
|
angiotensinogen |
|
| chr4_+_112860912 Show fit | 6.95 |
ENST00000671951.1
|
ankyrin 2 |
|
| chr8_+_22275309 Show fit | 6.86 |
ENST00000356766.11
ENST00000521356.5 |
piwi like RNA-mediated gene silencing 2 |
|
| chr19_+_17527250 Show fit | 6.75 |
ENST00000599164.6
ENST00000449408.6 ENST00000600871.5 ENST00000599124.1 |
niban apoptosis regulator 3 |
|
| chr4_+_112861053 Show fit | 6.73 |
ENST00000672221.1
|
ankyrin 2 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 20.9 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
| 1.6 | 15.7 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 0.1 | 12.7 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 0.2 | 12.4 | GO:0007032 | endosome organization(GO:0007032) |
| 0.1 | 9.4 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 8.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.7 | 8.7 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.1 | 8.0 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 1.1 | 7.8 | GO:0048241 | epinephrine transport(GO:0048241) |
| 0.1 | 7.7 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 20.9 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 11.7 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 11.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 10.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.2 | 9.3 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 8.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 1.7 | 6.9 | GO:0071546 | pi-body(GO:0071546) |
| 0.4 | 6.7 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.4 | 6.4 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 6.3 | GO:0005911 | cell-cell junction(GO:0005911) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 22.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 20.9 | GO:0030507 | spectrin binding(GO:0030507) |
| 2.9 | 17.1 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 1.1 | 15.7 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 12.7 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.1 | 11.3 | GO:0002020 | protease binding(GO:0002020) |
| 0.1 | 9.7 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.1 | 9.3 | GO:0004521 | endoribonuclease activity(GO:0004521) |
| 0.0 | 8.6 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.3 | 8.0 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.5 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.1 | 7.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.0 | 7.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.8 | PID CD40 PATHWAY | CD40/CD40L signaling |
| 0.0 | 5.7 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.0 | 3.7 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 3.6 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.0 | 3.5 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.1 | 3.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 19.0 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |
| 0.2 | 17.6 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 12.3 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 12.3 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.7 | 9.8 | REACTOME ABACAVIR TRANSPORT AND METABOLISM | Genes involved in Abacavir transport and metabolism |
| 0.6 | 9.7 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 8.2 | REACTOME GENERIC TRANSCRIPTION PATHWAY | Genes involved in Generic Transcription Pathway |
| 0.5 | 7.7 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |
| 0.1 | 6.4 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 5.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |