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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXB4_LHX9
Z-value: 0.72
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Transcription factors associated with HOXB4_LHX9
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB4_LHX9
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_168497066 Show fit | 23.85 |
ENST00000261509.10
|
palladin, cytoskeletal associated protein |
|
| chr4_+_168497044 Show fit | 20.59 |
ENST00000505667.6
|
palladin, cytoskeletal associated protein |
|
| chr15_-_72231583 Show fit | 18.41 |
ENST00000566809.1
ENST00000567087.5 ENST00000569050.1 ENST00000568883.5 |
pyruvate kinase M1/2 |
|
| chr14_+_34993240 Show fit | 16.51 |
ENST00000677647.1
|
signal recognition particle 54 |
|
| chr15_-_60398733 Show fit | 15.51 |
ENST00000559818.6
|
annexin A2 |
|
| chr7_-_88226987 Show fit | 14.87 |
ENST00000394641.7
|
sorcin |
|
| chr7_-_88226965 Show fit | 14.82 |
ENST00000490437.5
ENST00000431660.5 |
sorcin |
|
| chr14_+_61697622 Show fit | 14.41 |
ENST00000539097.2
|
hypoxia inducible factor 1 subunit alpha |
|
| chr3_-_64019334 Show fit | 14.05 |
ENST00000480205.5
|
proteasome 26S subunit, non-ATPase 6 |
|
| chr6_-_38703066 Show fit | 13.26 |
ENST00000373365.5
|
glyoxalase I |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 46.0 | GO:0003334 | keratinocyte development(GO:0003334) |
| 4.2 | 29.7 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.6 | 28.0 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 5.5 | 27.3 | GO:0044111 | development involved in symbiotic interaction(GO:0044111) |
| 1.4 | 19.6 | GO:0051096 | positive regulation of helicase activity(GO:0051096) |
| 2.3 | 18.4 | GO:0042866 | pyruvate biosynthetic process(GO:0042866) |
| 0.2 | 17.5 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 2.4 | 17.1 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 4.1 | 16.5 | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617) |
| 0.2 | 14.1 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 46.0 | GO:0002102 | podosome(GO:0002102) |
| 4.2 | 29.7 | GO:0044326 | dendritic spine neck(GO:0044326) |
| 3.9 | 27.3 | GO:0044352 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.0 | 23.4 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.1 | 21.6 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.4 | 19.6 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 1.8 | 16.5 | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting(GO:0005786) |
| 0.7 | 15.3 | GO:0071004 | U2-type prespliceosome(GO:0071004) |
| 0.3 | 14.4 | GO:1904115 | axon cytoplasm(GO:1904115) |
| 0.5 | 14.1 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 43.0 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.7 | 31.6 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.7 | 29.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 5.5 | 27.3 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 25.5 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.4 | 24.7 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.1 | 21.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 18.7 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 4.6 | 18.4 | GO:0004743 | pyruvate kinase activity(GO:0004743) |
| 2.8 | 16.5 | GO:0030942 | endoplasmic reticulum signal peptide binding(GO:0030942) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 44.1 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.1 | 22.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 14.4 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 0.2 | 13.9 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 13.1 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.3 | 11.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.2 | 10.6 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 8.2 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.2 | 8.1 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.2 | 7.4 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 46.0 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 0.1 | 22.6 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.2 | 20.6 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.9 | 14.0 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 0.1 | 12.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.5 | 12.5 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.1 | 11.7 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.4 | 11.2 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.4 | 10.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.3 | 10.5 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |