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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXB5
Z-value: 0.46
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Transcription factors associated with HOXB5
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB5 | hg38_v1_chr17_-_48593748_48593786 | 0.21 | 1.4e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB5
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chrX_+_48521817 Show fit | 11.73 |
ENST00000446158.5
ENST00000414061.1 |
EBP cholestenol delta-isomerase |
|
| chrX_+_48521788 Show fit | 7.71 |
ENST00000651615.1
ENST00000495186.6 |
novel protein EBP cholestenol delta-isomerase |
|
| chr19_-_49640092 Show fit | 6.22 |
ENST00000246792.4
|
RAS related |
|
| chr14_-_102238439 Show fit | 5.40 |
ENST00000522534.5
|
MOK protein kinase |
|
| chr15_+_73926443 Show fit | 4.40 |
ENST00000261921.8
|
lysyl oxidase like 1 |
|
| chr2_-_46941710 Show fit | 3.97 |
ENST00000409207.5
|
multiple coagulation factor deficiency 2, ER cargo receptor complex subunit |
|
| chr1_-_161223408 Show fit | 3.16 |
ENST00000491350.1
|
apolipoprotein A2 |
|
| chr1_-_161223559 Show fit | 3.15 |
ENST00000469730.2
ENST00000463273.5 ENST00000464492.5 ENST00000367990.7 ENST00000470459.6 ENST00000463812.1 ENST00000468465.5 |
apolipoprotein A2 |
|
| chr3_-_127822455 Show fit | 2.64 |
ENST00000265052.10
|
monoglyceride lipase |
|
| chr3_+_51385282 Show fit | 2.29 |
ENST00000528157.7
|
mesencephalic astrocyte derived neurotrophic factor |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.2 | 19.4 | GO:0033489 | cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490) |
| 1.6 | 6.3 | GO:0060620 | regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910) |
| 0.1 | 6.2 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.1 | 6.2 | GO:0018279 | protein N-linked glycosylation via asparagine(GO:0018279) |
| 0.1 | 4.4 | GO:0035904 | aorta development(GO:0035904) |
| 0.0 | 3.6 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.9 | 3.5 | GO:0042361 | menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377) |
| 0.1 | 2.9 | GO:0050832 | defense response to fungus(GO:0050832) |
| 0.3 | 2.6 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.1 | 2.3 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 20.3 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.4 | 6.3 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 6.3 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 6.2 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.1 | 5.4 | GO:0097546 | ciliary base(GO:0097546) |
| 0.0 | 4.9 | GO:0001669 | acrosomal vesicle(GO:0001669) |
| 0.0 | 4.4 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.3 | 3.6 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.2 | 2.9 | GO:0033202 | Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202) |
| 0.0 | 2.9 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 19.4 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.1 | 7.0 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 1.3 | 6.3 | GO:0070653 | high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.1 | 6.2 | GO:0019003 | GDP binding(GO:0019003) |
| 0.2 | 4.4 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.0 | 3.6 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
| 0.1 | 3.5 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.2 | 2.6 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.4 | 2.1 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
| 0.1 | 1.7 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 19.4 | SIG PIP3 SIGNALING IN CARDIAC MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 5.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 3.6 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.0 | 0.8 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 0.6 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 0.1 | 6.5 | REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE | Genes involved in Cytochrome P450 - arranged by substrate type |
| 0.3 | 6.3 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.3 | 6.2 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.1 | 6.2 | REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION | Genes involved in Transport to the Golgi and subsequent modification |
| 0.1 | 2.6 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 2.1 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 1.3 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.8 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.0 | 0.6 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |