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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXB6_PRRX2
Z-value: 2.66
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Transcription factors associated with HOXB6_PRRX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| PRRX2 | hg38_v1_chr9_+_129665603_129665672 | 0.52 | 3.0e-16 | Click! |
| HOXB6 | hg38_v1_chr17_-_48604959_48605000 | -0.08 | 2.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB6_PRRX2
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_16608073 Show fit | 181.25 |
ENST00000441439.6
|
LIM domain only 3 |
|
| chr12_-_16608183 Show fit | 171.95 |
ENST00000354662.5
ENST00000538051.5 |
LIM domain only 3 |
|
| chr4_-_175812746 Show fit | 154.44 |
ENST00000393658.6
|
glycoprotein M6A |
|
| chr2_-_2324323 Show fit | 136.23 |
ENST00000648339.1
ENST00000647694.1 |
myelin transcription factor 1 like |
|
| chr2_-_2324642 Show fit | 86.94 |
ENST00000650485.1
ENST00000649207.1 |
myelin transcription factor 1 like |
|
| chr2_-_174846405 Show fit | 84.97 |
ENST00000409597.5
ENST00000413882.6 |
chimerin 1 |
|
| chr12_-_16606795 Show fit | 80.48 |
ENST00000447609.5
|
LIM domain only 3 |
|
| chr5_-_88883701 Show fit | 73.54 |
ENST00000636998.1
|
myocyte enhancer factor 2C |
|
| chr16_+_7332839 Show fit | 73.07 |
ENST00000355637.9
|
RNA binding fox-1 homolog 1 |
|
| chr16_+_7303245 Show fit | 71.50 |
ENST00000674626.1
|
RNA binding fox-1 homolog 1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 79.8 | 558.9 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 1.4 | 378.0 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 7.9 | 282.9 | GO:0048665 | neuron fate specification(GO:0048665) |
| 19.1 | 210.3 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 2.6 | 193.5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 6.0 | 161.0 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 2.4 | 155.5 | GO:0003254 | regulation of membrane depolarization(GO:0003254) |
| 3.9 | 143.6 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.9 | 143.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 13.7 | 136.6 | GO:0036371 | protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 328.9 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.9 | 300.9 | GO:0060076 | excitatory synapse(GO:0060076) |
| 2.5 | 299.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.9 | 237.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 3.5 | 205.3 | GO:0031430 | M band(GO:0031430) |
| 4.4 | 177.5 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.7 | 172.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 0.7 | 162.2 | GO:0098794 | postsynapse(GO:0098794) |
| 0.0 | 155.8 | GO:0016021 | integral component of membrane(GO:0016021) |
| 6.2 | 154.1 | GO:0044295 | axonal growth cone(GO:0044295) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 21.6 | 453.4 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 1.9 | 363.1 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 8.8 | 210.3 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.7 | 185.3 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.9 | 182.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 1.6 | 177.7 | GO:0005262 | calcium channel activity(GO:0005262) |
| 2.0 | 169.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 2.3 | 164.0 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 2.6 | 160.6 | GO:0030507 | spectrin binding(GO:0030507) |
| 8.6 | 146.7 | GO:0003680 | AT DNA binding(GO:0003680) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 301.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 2.3 | 148.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 1.8 | 134.6 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 2.0 | 123.7 | PID MAPK TRK PATHWAY | Trk receptor signaling mediated by the MAPK pathway |
| 1.9 | 118.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 1.9 | 112.9 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.9 | 81.1 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.9 | 74.9 | PID LKB1 PATHWAY | LKB1 signaling events |
| 1.1 | 74.7 | PID FGF PATHWAY | FGF signaling pathway |
| 0.6 | 36.8 | PID NFAT 3PATHWAY | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.0 | 592.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 4.7 | 178.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 6.6 | 144.7 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.7 | 128.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 3.1 | 124.2 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 | Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| 2.5 | 106.7 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 3.8 | 102.0 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 3.6 | 93.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 1.8 | 71.9 | REACTOME RAP1 SIGNALLING | Genes involved in Rap1 signalling |
| 2.7 | 71.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |