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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXB8
Z-value: 0.79
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Transcription factors associated with HOXB8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXB8 | hg38_v1_chr17_-_48613468_48613522 | 0.19 | 4.6e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXB8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_107824294 Show fit | 15.41 |
ENST00000369020.8
ENST00000369022.6 |
Scm polycomb group protein like 4 |
|
| chr8_+_81280527 Show fit | 6.79 |
ENST00000297258.11
|
fatty acid binding protein 5 |
|
| chr19_-_10587219 Show fit | 5.82 |
ENST00000591240.5
ENST00000589684.5 ENST00000591676.1 ENST00000250244.11 ENST00000590923.5 |
adaptor related protein complex 1 subunit mu 2 |
|
| chr8_-_80171106 Show fit | 5.78 |
ENST00000519303.6
|
tumor protein D52 |
|
| chr14_-_106658251 Show fit | 5.36 |
ENST00000454421.2
|
immunoglobulin heavy variable 3-64 |
|
| chr3_-_111595339 Show fit | 5.36 |
ENST00000317012.5
|
zinc finger BED-type containing 2 |
|
| chr19_-_20565746 Show fit | 4.82 |
ENST00000594419.1
|
zinc finger protein 737 |
|
| chr8_+_133113483 Show fit | 4.48 |
ENST00000521107.1
|
thyroglobulin |
|
| chr13_+_73054969 Show fit | 4.41 |
ENST00000539231.5
|
Kruppel like factor 5 |
|
| chr5_-_126595237 Show fit | 4.33 |
ENST00000637206.1
ENST00000553117.5 |
aldehyde dehydrogenase 7 family member A1 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 28.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.8 | 10.2 | GO:0052697 | flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697) |
| 0.2 | 7.5 | GO:0019433 | triglyceride catabolic process(GO:0019433) |
| 0.3 | 7.4 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.7 | 6.5 | GO:0052695 | cellular glucuronidation(GO:0052695) |
| 0.0 | 6.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 6.2 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 1.5 | 6.0 | GO:1900158 | positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158) |
| 2.0 | 5.9 | GO:0019285 | glycine betaine biosynthetic process from choline(GO:0019285) glycine betaine metabolic process(GO:0031455) glycine betaine biosynthetic process(GO:0031456) |
| 0.1 | 5.8 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 57.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.1 | 20.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 16.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 15.1 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 14.1 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.3 | 13.9 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.0 | 8.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.0 | 8.2 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 7.9 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 7.8 | GO:0001772 | immunological synapse(GO:0001772) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 22.1 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.1 | 20.4 | GO:0003823 | antigen binding(GO:0003823) |
| 0.2 | 13.4 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.1 | 10.6 | GO:0005179 | hormone activity(GO:0005179) |
| 0.2 | 7.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 7.1 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 6.9 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.1 | 6.7 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.3 | 6.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 6.5 | GO:0045296 | cadherin binding(GO:0045296) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 16.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 9.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.0 | 5.8 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 5.7 | PID AJDISS 2PATHWAY | Posttranslational regulation of adherens junction stability and dissassembly |
| 0.1 | 5.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 5.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 5.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.1 | 5.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.1 | 4.7 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 21.8 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 12.2 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 8.2 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.6 | 7.4 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.4 | 7.4 | REACTOME AMINE DERIVED HORMONES | Genes involved in Amine-derived hormones |
| 0.5 | 7.2 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.4 | 6.9 | REACTOME TRANSPORT OF ORGANIC ANIONS | Genes involved in Transport of organic anions |
| 0.0 | 6.6 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.1 | 6.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.1 | 5.9 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |