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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXC10_HOXD13
Z-value: 1.02
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Transcription factors associated with HOXC10_HOXD13
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD13 | hg38_v1_chr2_+_176092715_176092729 | 0.23 | 5.8e-04 | Click! |
| HOXC10 | hg38_v1_chr12_+_53985138_53985183 | -0.12 | 7.3e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC10_HOXD13
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.9 | 76.2 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.1 | 42.6 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 7.1 | 35.5 | GO:1904209 | regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) |
| 11.4 | 34.3 | GO:2000097 | regulation of smooth muscle cell-matrix adhesion(GO:2000097) |
| 2.9 | 29.3 | GO:0006537 | glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449) |
| 8.8 | 26.3 | GO:0052047 | interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047) |
| 1.4 | 23.4 | GO:0090360 | platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361) |
| 0.3 | 22.5 | GO:0006501 | C-terminal protein lipidation(GO:0006501) |
| 2.7 | 21.3 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 3.4 | 20.4 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.4 | 82.7 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 55.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.3 | 47.7 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 34.5 | GO:0043025 | neuronal cell body(GO:0043025) |
| 5.6 | 33.8 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.2 | 33.5 | GO:0022626 | cytosolic ribosome(GO:0022626) |
| 2.2 | 32.8 | GO:0030478 | actin cap(GO:0030478) |
| 2.0 | 23.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 1.2 | 23.6 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 22.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 138.0 | GO:0005518 | collagen binding(GO:0005518) |
| 2.7 | 56.6 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.4 | 40.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.5 | 34.3 | GO:0015485 | cholesterol binding(GO:0015485) |
| 2.8 | 33.8 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 1.2 | 32.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 2.1 | 29.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.7 | 27.5 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.2 | 23.0 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.8 | 21.3 | GO:0008430 | selenium binding(GO:0008430) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 86.0 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.4 | 55.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.6 | 28.7 | NABA COLLAGENS | Genes encoding collagen proteins |
| 1.0 | 26.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.4 | 24.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.1 | 24.0 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.4 | 21.0 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 18.4 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.1 | 17.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 15.9 | PID FGF PATHWAY | FGF signaling pathway |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.8 | 76.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.8 | 62.9 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 1.0 | 53.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.4 | 32.3 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 1.2 | 30.9 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.4 | 28.7 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.5 | 18.4 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.8 | 18.2 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 0.2 | 17.8 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |
| 0.1 | 13.4 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |