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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXC12_HOXD12
Z-value: 1.05
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Transcription factors associated with HOXC12_HOXD12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD12 | hg38_v1_chr2_+_176099787_176099812 | -0.46 | 5.7e-13 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC12_HOXD12
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.9 | 62.7 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) |
| 1.3 | 42.4 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.9 | 42.2 | GO:0031577 | spindle checkpoint(GO:0031577) |
| 0.5 | 40.5 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 24.8 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
| 2.9 | 23.3 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 1.5 | 21.4 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.3 | 19.4 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.4 | 19.3 | GO:0014904 | myotube cell development(GO:0014904) |
| 0.7 | 17.7 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.3 | 62.7 | GO:0071541 | eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541) |
| 0.9 | 37.7 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.5 | 37.3 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 27.5 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.1 | 25.4 | GO:0016607 | nuclear speck(GO:0016607) |
| 6.0 | 23.9 | GO:1990423 | RZZ complex(GO:1990423) |
| 0.2 | 23.3 | GO:0000784 | nuclear chromosome, telomeric region(GO:0000784) |
| 1.4 | 21.4 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 7.0 | 21.1 | GO:0033597 | mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298) |
| 0.2 | 19.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 20.9 | 62.7 | GO:0098808 | mRNA cap binding(GO:0098808) |
| 0.2 | 49.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.1 | 24.7 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 1.3 | 23.8 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.4 | 22.7 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.7 | 21.4 | GO:0070034 | telomerase RNA binding(GO:0070034) |
| 0.2 | 20.4 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 2.8 | 19.3 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 1.9 | 19.3 | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162) |
| 0.1 | 18.3 | GO:0042393 | histone binding(GO:0042393) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 32.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.2 | 20.3 | PID P73PATHWAY | p73 transcription factor network |
| 0.3 | 20.1 | PID ERBB1 INTERNALIZATION PATHWAY | Internalization of ErbB1 |
| 0.3 | 17.3 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.2 | 15.2 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.4 | 14.5 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.3 | 13.4 | PID MYC PATHWAY | C-MYC pathway |
| 0.2 | 13.3 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.3 | 12.5 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.0 | 12.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 58.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.2 | 32.6 | REACTOME MRNA PROCESSING | Genes involved in mRNA Processing |
| 0.8 | 25.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 24.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.7 | 24.5 | REACTOME SIGNALING BY FGFR1 FUSION MUTANTS | Genes involved in Signaling by FGFR1 fusion mutants |
| 0.2 | 23.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.3 | 22.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.8 | 21.1 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 0.8 | 18.3 | REACTOME PURINE SALVAGE | Genes involved in Purine salvage |
| 1.3 | 15.6 | REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE | Genes involved in mRNA Decay by 3' to 5' Exoribonuclease |