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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXC6_HOXA7
Z-value: 0.76
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Transcription factors associated with HOXC6_HOXA7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXC6 | hg38_v1_chr12_+_54028433_54028455 | -0.23 | 6.4e-04 | Click! |
| HOXA7 | hg38_v1_chr7_-_27156646_27156693 | 0.10 | 1.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC6_HOXA7
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_+_49513353 Show fit | 13.76 |
ENST00000596975.5
|
Fc fragment of IgG receptor and transporter |
|
| chr2_-_89027700 Show fit | 12.81 |
ENST00000483158.1
|
immunoglobulin kappa variable 3-11 |
|
| chr2_+_90038848 Show fit | 12.61 |
ENST00000390270.2
|
immunoglobulin kappa variable 3D-20 |
|
| chr17_+_1771688 Show fit | 11.83 |
ENST00000572048.1
ENST00000573763.1 |
serpin family F member 1 |
|
| chr2_+_87338511 Show fit | 11.39 |
ENST00000421835.2
|
immunoglobulin kappa variable 3/OR2-268 (non-functional) |
|
| chr14_-_106470788 Show fit | 11.29 |
ENST00000434710.1
|
immunoglobulin heavy variable 3-43 |
|
| chr2_+_90234809 Show fit | 11.15 |
ENST00000443397.5
|
immunoglobulin kappa variable 3D-7 |
|
| chr2_-_88979016 Show fit | 10.13 |
ENST00000390247.2
|
immunoglobulin kappa variable 3-7 (non-functional) |
|
| chr2_+_90172802 Show fit | 9.64 |
ENST00000390277.3
|
immunoglobulin kappa variable 3D-11 |
|
| chr2_-_89143133 Show fit | 9.25 |
ENST00000492167.1
|
immunoglobulin kappa variable 3-20 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 50.2 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.3 | 49.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.9 | 27.9 | GO:0072643 | interferon-gamma secretion(GO:0072643) |
| 1.7 | 22.4 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.9 | 18.5 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 4.6 | 13.8 | GO:0002416 | IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416) |
| 1.7 | 11.8 | GO:0071279 | negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279) |
| 0.2 | 11.2 | GO:0080171 | lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171) |
| 2.9 | 8.7 | GO:0070105 | positive regulation of interleukin-6-mediated signaling pathway(GO:0070105) |
| 2.0 | 7.9 | GO:0002881 | negative regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002881) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 73.5 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 51.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.7 | 22.4 | GO:0005589 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 18.0 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
| 0.4 | 13.2 | GO:0035371 | microtubule plus-end(GO:0035371) |
| 0.1 | 12.8 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.1 | 11.8 | GO:0043203 | axon hillock(GO:0043203) |
| 0.2 | 11.3 | GO:0042571 | immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 9.4 | GO:0016363 | nuclear matrix(GO:0016363) |
| 3.1 | 9.3 | GO:0071756 | IgM immunoglobulin complex(GO:0071753) IgM immunoglobulin complex, circulating(GO:0071754) pentameric IgM immunoglobulin complex(GO:0071756) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 75.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.3 | 27.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 3.7 | 18.5 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 3.4 | 13.8 | GO:0019770 | IgG receptor activity(GO:0019770) |
| 0.1 | 13.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 12.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 11.8 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 8.7 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 2.0 | 7.9 | GO:0016495 | C-X3-C chemokine receptor activity(GO:0016495) |
| 0.2 | 6.0 | GO:0038187 | signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 21.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 17.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 11.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.9 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 4.0 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 3.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.1 | 2.3 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 2.0 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 1.8 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 1.6 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.7 | REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS | Genes involved in Phase 1 - Functionalization of compounds |
| 0.8 | 22.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 8.0 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.1 | 5.6 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.5 | 5.2 | REACTOME ENDOSOMAL VACUOLAR PATHWAY | Genes involved in Endosomal/Vacuolar pathway |
| 0.2 | 4.9 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.1 | 4.5 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.2 | 3.3 | REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 | Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| 0.0 | 2.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.3 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |