Project
GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for HOXC8
Z-value: 1.38
Motif logo
Transcription factors associated with HOXC8
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXC8 | hg38_v1_chr12_+_54008961_54009005 | -0.58 | 1.2e-20 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC8
| Promoter | Score | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr8_-_27838034 Show fit | 34.48 |
ENST00000522944.5
|
PDZ binding kinase |
|
| chr21_-_29061351 Show fit | 33.50 |
ENST00000432178.5
|
chaperonin containing TCP1 subunit 8 |
|
| chr5_+_168486462 Show fit | 28.57 |
ENST00000231572.8
ENST00000626454.1 |
arginyl-tRNA synthetase 1 |
|
| chr8_+_54135203 Show fit | 26.28 |
ENST00000260102.9
ENST00000519831.5 |
mitochondrial ribosomal protein L15 |
|
| chr13_-_37105664 Show fit | 25.06 |
ENST00000379800.4
|
casein kinase 1 alpha 1 like |
|
| chrX_+_120604084 Show fit | 24.42 |
ENST00000371317.10
|
MCTS1 re-initiation and release factor |
|
| chr12_+_68686951 Show fit | 23.21 |
ENST00000378905.6
ENST00000229179.9 |
nucleoporin 107 |
|
| chr20_+_3786772 Show fit | 23.20 |
ENST00000344256.10
ENST00000379598.9 |
cell division cycle 25B |
|
| chr19_+_49676140 Show fit | 23.12 |
ENST00000527382.5
ENST00000528623.5 |
protein arginine methyltransferase 1 |
|
| chr3_-_64023986 Show fit | 23.09 |
ENST00000394431.6
|
proteasome 26S subunit, non-ATPase 6 |
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 80.4 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
| 1.5 | 78.2 | GO:0051123 | RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123) |
| 0.6 | 77.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 1.6 | 61.3 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.9 | 60.7 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 12.8 | 51.2 | GO:0002188 | translation reinitiation(GO:0002188) |
| 3.6 | 50.4 | GO:1904871 | regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) |
| 3.5 | 45.3 | GO:1900623 | regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625) |
| 4.9 | 43.9 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 1.0 | 31.2 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 113.4 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.6 | 58.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.9 | 50.4 | GO:0002199 | zona pellucida receptor complex(GO:0002199) |
| 2.3 | 47.6 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.5 | 45.6 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 45.6 | GO:0016607 | nuclear speck(GO:0016607) |
| 4.1 | 45.3 | GO:0035692 | macrophage migration inhibitory factor receptor complex(GO:0035692) |
| 7.2 | 43.0 | GO:0042721 | mitochondrial inner membrane protein insertion complex(GO:0042721) |
| 0.3 | 40.6 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.2 | 40.2 | GO:0005819 | spindle(GO:0005819) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 178.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.3 | 116.0 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 71.5 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.7 | 67.7 | GO:0070491 | repressing transcription factor binding(GO:0070491) |
| 0.5 | 67.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.9 | 63.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.3 | 50.0 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
| 1.5 | 46.2 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 1.2 | 46.2 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 1.3 | 37.9 | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 54.5 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.9 | 52.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 3.5 | 49.3 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.8 | 47.9 | PID ATR PATHWAY | ATR signaling pathway |
| 1.2 | 45.3 | SA MMP CYTOKINE CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.6 | 36.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.9 | 28.1 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.5 | 26.0 | PID MYC PATHWAY | C-MYC pathway |
| 0.2 | 22.7 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.5 | 19.4 | PID BARD1 PATHWAY | BARD1 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 97.3 | REACTOME ASSEMBLY OF THE PRE REPLICATIVE COMPLEX | Genes involved in Assembly of the pre-replicative complex |
| 0.9 | 75.8 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 1.0 | 74.4 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 1.3 | 72.2 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 2.3 | 67.8 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.6 | 65.1 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 1.0 | 61.9 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 1.7 | 53.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.5 | 50.9 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.6 | 47.6 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |