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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXC9
Z-value: 0.74
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Transcription factors associated with HOXC9
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXC9
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 10.6 | GO:0009786 | regulation of asymmetric cell division(GO:0009786) |
| 0.4 | 7.4 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.0 | 6.9 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.0 | 6.8 | GO:0030183 | B cell differentiation(GO:0030183) |
| 1.6 | 6.5 | GO:0046900 | tetrahydrofolylpolyglutamate metabolic process(GO:0046900) |
| 1.1 | 6.3 | GO:1990034 | calcium ion export from cell(GO:1990034) |
| 0.5 | 5.5 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 1.4 | 5.4 | GO:0071418 | cellular response to amine stimulus(GO:0071418) |
| 0.9 | 5.3 | GO:0006001 | fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) |
| 0.6 | 5.3 | GO:2000332 | response to linoleic acid(GO:0070543) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 17.2 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 1.2 | 10.6 | GO:0036449 | microtubule minus-end(GO:0036449) meiotic spindle(GO:0072687) |
| 0.1 | 7.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.7 | 7.4 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.1 | 6.4 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.3 | 6.3 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.0 | 5.9 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 5.6 | GO:0045121 | membrane raft(GO:0045121) |
| 0.0 | 5.6 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.2 | 5.5 | GO:0035371 | microtubule plus-end(GO:0035371) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 9.4 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 8.1 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.8 | 7.4 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.5 | 7.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.4 | 6.5 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.2 | 6.3 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 6.1 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 5.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 0.3 | 5.5 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 8.1 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.1 | 5.3 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 4.4 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 2.9 | PID MYC PATHWAY | C-MYC pathway |
| 0.0 | 2.8 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 2.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 2.5 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.5 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.0 | 2.3 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.6 | REACTOME GLUCURONIDATION | Genes involved in Glucuronidation |
| 0.1 | 9.4 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.1 | 8.0 | REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS | Genes involved in Amino acid and oligopeptide SLC transporters |
| 0.1 | 6.3 | REACTOME G ALPHA Z SIGNALLING EVENTS | Genes involved in G alpha (z) signalling events |
| 0.1 | 6.1 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.1 | 5.7 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.2 | 5.4 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 5.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 5.0 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.1 | 4.5 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |