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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXD1

Z-value: 0.39

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Transcription factors associated with HOXD1

Gene Symbol Gene ID Gene Info
HOXD1
ENSG00000128645.15 HOXD1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXD1hg38_v1_chr2_+_176188658_176188674-0.291.2e-05Click!

Activity profile of HOXD1 motif

Sorted Z-values of HOXD1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_186506713 10.16 ENST00000445547.1
ZC3H15
zinc finger CCCH-type containing 15
chrX_+_77899440 5.80 ENST00000373335.4
ENST00000475465.1
ENST00000650309.2
ENST00000647835.1
COX7B
cytochrome c oxidase subunit 7B
chr12_+_28257195 5.09 ENST00000381259.5
CCDC91
coiled-coil domain containing 91
chr15_-_37101205 4.94 ENST00000338564.9
ENST00000558313.5
ENST00000340545.9
MEIS2
Meis homeobox 2
chr15_-_55270874 4.51 ENST00000567380.5
ENST00000565972.5
ENST00000569493.5
RAB27A
RAB27A, member RAS oncogene family
chrX_+_115593570 4.02 ENST00000539310.5
PLS3
plastin 3
chr3_+_158801926 3.99 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
MFSD1
major facilitator superfamily domain containing 1
chr15_-_55270280 3.81 ENST00000564609.5
RAB27A
RAB27A, member RAS oncogene family
chr4_+_112647059 3.74 ENST00000511529.1
LARP7
La ribonucleoprotein 7, transcriptional regulator
chr12_-_118359639 3.70 ENST00000541786.5
ENST00000419821.6
ENST00000541878.5
TAOK3
TAO kinase 3
chr22_+_24555981 3.63 ENST00000215829.8
ENST00000402849.5
SNRPD3
small nuclear ribonucleoprotein D3 polypeptide
chr6_+_121437378 3.39 ENST00000650427.1
ENST00000647564.1
GJA1
gap junction protein alpha 1
chr6_-_110179995 2.95 ENST00000392586.5
ENST00000419252.1
ENST00000359451.6
ENST00000392588.5
WASF1
WASP family member 1
chr15_-_55270383 2.81 ENST00000396307.6
RAB27A
RAB27A, member RAS oncogene family
chr11_-_95923763 2.65 ENST00000497683.6
ENST00000470293.6
ENST00000674968.1
ENST00000484818.6
ENST00000675454.1
ENST00000675981.1
ENST00000674924.1
ENST00000676166.1
ENST00000676440.1
ENST00000675807.1
ENST00000495134.6
ENST00000675196.1
MTMR2
myotubularin related protein 2
chr12_+_64404338 2.46 ENST00000332707.10
XPOT
exportin for tRNA
chrX_+_108044967 2.43 ENST00000415430.7
VSIG1
V-set and immunoglobulin domain containing 1
chr3_+_111998915 2.38 ENST00000478951.6
TAGLN3
transgelin 3
chrX_+_108045050 2.37 ENST00000458383.1
ENST00000217957.10
VSIG1
V-set and immunoglobulin domain containing 1
chr3_+_111999326 2.17 ENST00000494932.1
TAGLN3
transgelin 3
chr3_+_111999189 2.08 ENST00000455401.6
TAGLN3
transgelin 3
chr13_+_35476740 2.02 ENST00000537702.5
NBEA
neurobeachin
chr3_+_111998739 2.00 ENST00000393917.6
ENST00000273368.8
TAGLN3
transgelin 3
chr6_+_106360668 1.91 ENST00000633556.3
CRYBG1
crystallin beta-gamma domain containing 1
chr5_+_36606355 1.90 ENST00000681909.1
ENST00000513903.5
ENST00000681795.1
ENST00000680125.1
ENST00000612708.5
ENST00000680232.1
ENST00000681776.1
ENST00000681926.1
ENST00000679958.1
ENST00000265113.9
ENST00000504121.5
ENST00000512374.1
ENST00000613445.5
ENST00000679983.1
SLC1A3
solute carrier family 1 member 3
chr12_+_29223730 1.85 ENST00000547116.5
FAR2
fatty acyl-CoA reductase 2
chr12_+_29223659 1.77 ENST00000182377.8
FAR2
fatty acyl-CoA reductase 2
chr11_-_72112750 1.70 ENST00000545680.5
ENST00000543587.5
ENST00000538393.5
ENST00000535234.5
ENST00000227618.8
ENST00000535503.5
ANAPC15
anaphase promoting complex subunit 15
chr19_+_10252206 1.68 ENST00000253099.11
ENST00000393733.6
ENST00000588502.5
MRPL4
mitochondrial ribosomal protein L4
chr11_-_72112068 1.64 ENST00000537644.5
ENST00000538919.5
ENST00000539395.1
ENST00000542531.5
ANAPC15
anaphase promoting complex subunit 15
chr2_+_54123179 1.55 ENST00000606865.1
ACYP2
acylphosphatase 2
chr8_-_48921419 1.54 ENST00000020945.4
SNAI2
snail family transcriptional repressor 2
chr1_-_151459169 1.48 ENST00000368863.6
ENST00000409503.5
ENST00000491586.5
ENST00000533351.5
POGZ
pogo transposable element derived with ZNF domain
chr11_-_72112669 1.47 ENST00000545944.5
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr1_-_151459471 1.43 ENST00000271715.7
POGZ
pogo transposable element derived with ZNF domain
chr6_-_111606260 1.34 ENST00000340026.10
TRAF3IP2
TRAF3 interacting protein 2
chr21_-_31160904 1.31 ENST00000636887.1
TIAM1
TIAM Rac1 associated GEF 1
chr11_-_95924067 1.31 ENST00000676027.1
ENST00000675489.1
ENST00000409459.5
ENST00000676261.1
ENST00000352297.11
ENST00000346299.10
ENST00000676272.1
ENST00000393223.8
ENST00000675022.1
ENST00000675362.1
ENST00000675174.1
ENST00000674989.1
ENST00000675848.1
ENST00000675652.1
ENST00000481642.6
MTMR2
myotubularin related protein 2
chr12_+_15546344 1.00 ENST00000674388.1
ENST00000542557.5
ENST00000445537.6
ENST00000544244.5
ENST00000442921.7
PTPRO
protein tyrosine phosphatase receptor type O
chr7_-_100119323 0.93 ENST00000523306.5
ENST00000344095.8
ENST00000417349.5
ENST00000493322.5
ENST00000520135.5
ENST00000460673.2
ENST00000453269.7
ENST00000452041.5
ENST00000452438.6
ENST00000451699.5
TAF6
TATA-box binding protein associated factor 6
chr20_+_9514562 0.88 ENST00000246070.3
LAMP5
lysosomal associated membrane protein family member 5
chr2_+_11542662 0.78 ENST00000389825.7
ENST00000381483.6
GREB1
growth regulating estrogen receptor binding 1
chrX_+_77910656 0.78 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATP7A
PGK1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr5_-_140346596 0.74 ENST00000230990.7
HBEGF
heparin binding EGF like growth factor
chr6_+_110180116 0.60 ENST00000368932.5
CDC40
cell division cycle 40
chr7_-_100119840 0.57 ENST00000437822.6
TAF6
TATA-box binding protein associated factor 6
chr4_-_25863537 0.57 ENST00000502949.5
ENST00000264868.9
ENST00000513691.1
ENST00000514872.1
SEL1L3
SEL1L family member 3
chr5_+_149357999 0.42 ENST00000274569.9
PCYOX1L
prenylcysteine oxidase 1 like
chr17_-_7263959 0.29 ENST00000571932.2
CLDN7
claudin 7
chr17_+_59155726 0.27 ENST00000578777.5
ENST00000577457.1
ENST00000582995.5
ENST00000262293.9
ENST00000614081.1
PRR11
proline rich 11
chr8_-_121641424 0.23 ENST00000303924.5
HAS2
hyaluronan synthase 2
chr10_+_18260715 0.19 ENST00000615785.4
ENST00000617363.4
ENST00000396576.6
CACNB2
calcium voltage-gated channel auxiliary subunit beta 2
chr6_-_111605859 0.16 ENST00000651359.1
ENST00000650859.1
ENST00000359831.8
ENST00000368761.11
TRAF3IP2
TRAF3 interacting protein 2
chr4_+_143433491 0.15 ENST00000512843.1
GAB1
GRB2 associated binding protein 1
chr5_+_177384430 0.14 ENST00000512593.5
ENST00000324417.6
SLC34A1
solute carrier family 34 member 1
chr8_-_42768602 0.09 ENST00000534622.5
CHRNA6
cholinergic receptor nicotinic alpha 6 subunit
chr1_+_117001744 0.09 ENST00000256652.8
ENST00000682167.1
ENST00000369470.1
CD101
CD101 molecule
chr1_+_177170916 0.07 ENST00000361539.5
BRINP2
BMP/retinoic acid inducible neural specific 2
chr5_+_157731400 0.06 ENST00000231198.12
THG1L
tRNA-histidine guanylyltransferase 1 like
chr6_+_110180418 0.03 ENST00000368930.5
ENST00000307731.2
CDC40
cell division cycle 40
chr3_-_165078480 0.02 ENST00000264382.8
SI
sucrase-isomaltase

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 11.1 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
1.2 3.6 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.8 3.4 GO:0010645 regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.5 1.5 GO:1901420 negative regulation of response to alcohol(GO:1901420)
0.4 5.1 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.4 3.0 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.4 4.0 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.3 1.3 GO:0036135 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.3 5.8 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.3 4.8 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.3 0.8 GO:1904732 copper ion export(GO:0060003) cellular response to lead ion(GO:0071284) regulation of electron carrier activity(GO:1904732)
0.2 1.0 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 4.8 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 1.9 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.2 4.0 GO:0051639 actin filament network formation(GO:0051639)
0.2 2.9 GO:0051382 kinetochore assembly(GO:0051382)
0.1 0.4 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 0.7 GO:0051541 elastin metabolic process(GO:0051541)
0.1 3.6 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.1 2.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 1.5 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.1 4.9 GO:0008542 visual learning(GO:0008542)
0.1 2.5 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.1 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.0 0.2 GO:0070295 renal water absorption(GO:0070295) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0 0.2 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
0.0 1.7 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.0 1.5 GO:0009301 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 11.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.5 3.6 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
0.4 5.8 GO:0045277 respiratory chain complex IV(GO:0045277)
0.2 3.0 GO:0031209 SCAR complex(GO:0031209)
0.2 3.4 GO:0005922 connexon complex(GO:0005922)
0.2 4.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 0.9 GO:0032584 growth cone membrane(GO:0032584)
0.1 3.6 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 1.5 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.1 1.3 GO:0044295 axonal growth cone(GO:0044295)
0.0 1.7 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 4.0 GO:0032432 actin filament bundle(GO:0032432)
0.0 8.6 GO:0043209 myelin sheath(GO:0043209)
0.0 7.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 4.0 GO:0031901 early endosome membrane(GO:0031901)
0.0 2.5 GO:0005643 nuclear pore(GO:0005643)
0.0 0.7 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 1.2 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 4.4 GO:0000790 nuclear chromatin(GO:0000790)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.9 3.6 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.6 3.4 GO:0086075 gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.4 11.1 GO:0031489 myosin V binding(GO:0031489)
0.3 1.6 GO:0003998 acylphosphatase activity(GO:0003998)
0.3 0.8 GO:0004618 copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682)
0.2 5.8 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.2 4.0 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 1.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 1.5 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 0.2 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 2.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 0.4 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
0.1 2.5 GO:0000049 tRNA binding(GO:0000049)
0.1 12.8 GO:0051015 actin filament binding(GO:0051015)
0.1 4.3 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 1.0 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 10.2 GO:0045296 cadherin binding(GO:0045296)
0.0 0.1 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0 0.1 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 4.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 1.5 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 3.4 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 1.3 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.0 3.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 2.7 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 11.1 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.2 4.0 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.2 3.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.2 3.4 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 3.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 5.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.5 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 1.9 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.7 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 1.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.8 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.6 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing