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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXD10
Z-value: 0.72
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Transcription factors associated with HOXD10
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXD10 | hg38_v1_chr2_+_176116768_176116794 | -0.19 | 5.8e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXD10
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 29.6 | GO:2000623 | regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623) |
| 0.1 | 18.5 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.1 | 17.1 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.2 | 16.5 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 3.8 | 15.2 | GO:0002399 | MHC class II protein complex assembly(GO:0002399) |
| 4.3 | 13.0 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 0.9 | 12.8 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.6 | 11.3 | GO:0040015 | negative regulation of multicellular organism growth(GO:0040015) |
| 0.8 | 10.4 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.1 | 10.1 | GO:0070527 | platelet aggregation(GO:0070527) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 32.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 1.2 | 29.6 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.1 | 25.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 23.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 13.8 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.1 | 12.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.3 | 11.3 | GO:0005826 | actomyosin contractile ring(GO:0005826) |
| 0.1 | 11.3 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 0.8 | 10.4 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 10.1 | GO:0016459 | myosin complex(GO:0016459) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 32.1 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 1.3 | 29.6 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.7 | 16.5 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 16.0 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 14.9 | GO:0003682 | chromatin binding(GO:0003682) |
| 0.3 | 11.3 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.3 | 10.9 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 10.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.2 | 8.9 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 8.8 | GO:0001047 | core promoter binding(GO:0001047) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 39.0 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.2 | 12.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 11.3 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 8.1 | PID IL2 STAT5 PATHWAY | IL2 signaling events mediated by STAT5 |
| 0.0 | 6.9 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 5.6 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.1 | 5.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.2 | 4.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 3.9 | PID TNF PATHWAY | TNF receptor signaling pathway |
| 0.3 | 3.6 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 39.3 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.8 | 29.6 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 19.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 10.4 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.1 | 6.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.1 | 6.3 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 0.2 | 5.4 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.2 | 4.9 | REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION | Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) |
| 0.4 | 4.7 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |
| 0.0 | 4.7 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |