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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for HOXD11_HOXA11
Z-value: 0.76
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Transcription factors associated with HOXD11_HOXA11
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| HOXA11 | hg38_v1_chr7_-_27185223_27185249 | -0.28 | 2.9e-05 | Click! |
| HOXD11 | hg38_v1_chr2_+_176107272_176107297 | -0.19 | 4.4e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of HOXD11_HOXA11
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 26.0 | GO:0000338 | protein deneddylation(GO:0000338) |
| 0.4 | 23.8 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.3 | 22.8 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.1 | 20.2 | GO:0007093 | mitotic cell cycle checkpoint(GO:0007093) |
| 1.1 | 19.3 | GO:0003322 | pancreatic A cell development(GO:0003322) |
| 0.8 | 16.8 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 1.4 | 16.4 | GO:2001288 | positive regulation of caveolin-mediated endocytosis(GO:2001288) |
| 0.1 | 14.6 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.4 | 13.5 | GO:0032402 | melanosome transport(GO:0032402) |
| 2.7 | 11.0 | GO:0035519 | protein K29-linked ubiquitination(GO:0035519) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 30.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 4.7 | 23.4 | GO:0045272 | plasma membrane respiratory chain complex I(GO:0045272) |
| 0.0 | 18.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 4.4 | 17.7 | GO:1990423 | RZZ complex(GO:1990423) |
| 1.7 | 17.3 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.2 | 16.4 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.1 | 14.2 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 12.2 | GO:0005819 | spindle(GO:0005819) |
| 0.6 | 11.9 | GO:0042405 | nuclear inclusion body(GO:0042405) |
| 0.4 | 11.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 22.5 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
| 0.3 | 19.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 1.9 | 17.3 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 0.9 | 16.4 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 12.9 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.4 | 12.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.3 | 11.8 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.2 | 9.9 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.3 | 9.6 | GO:0015248 | sterol transporter activity(GO:0015248) |
| 0.6 | 9.5 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.0 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.1 | 17.4 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 10.6 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.3 | 9.5 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.2 | 8.6 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.1 | 6.8 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.5 | 6.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 6.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 6.4 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| 0.1 | 5.5 | PID CMYB PATHWAY | C-MYB transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 27.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.5 | 19.1 | REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP | Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) |
| 0.2 | 15.8 | REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT | Genes involved in p53-Independent G1/S DNA damage checkpoint |
| 0.2 | 15.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 12.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 12.1 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.3 | 10.1 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.5 | 9.5 | REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY | Genes involved in Adenylate cyclase inhibitory pathway |
| 0.4 | 8.8 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.2 | 6.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |