ISMARA results: HOXD4

Project

GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

Navigation

Downloads

Results for HOXD4

Z-value: 0.85

Motif logo

Transcription factors associated with HOXD4

Gene Symbol	Gene ID	Gene Info
HOXD4 Ensembl NCBI GeneCards UniProt	ENSG00000170166.6	HOXD4

Activity profile of HOXD4 motif

Sorted Z-values of HOXD4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD4

View svg image
View png image

Top targets:

Search:

Show entries

Promoter	Score	Transcript	Gene	Gene Info
chr5_-_179617581 Show fit	21.21	ENST00000523449.5	HNRNPH1 Ensembl NCBI GeneCards UniProt Show fit	heterogeneous nuclear ribonucleoprotein H1
chr8_-_80029826 Show fit	15.35	ENST00000519386.5	MRPS28 Ensembl NCBI GeneCards UniProt Show fit	mitochondrial ribosomal protein S28
chr3_+_159069252 Show fit	14.70	ENST00000640015.1 ENST00000476809.7 ENST00000485419.7	IQCJ-SCHIP1 Ensembl NCBI GeneCards UniProt Show fit	IQCJ-SCHIP1 readthrough
chr2_-_224569782 Show fit	14.33	ENST00000409096.5	CUL3 Ensembl NCBI GeneCards UniProt Show fit	cullin 3
chr13_-_23433676 Show fit	14.30	ENST00000682547.1 ENST00000455470.6 ENST00000382292.9	SACS Ensembl NCBI GeneCards UniProt Show fit	sacsin molecular chaperone
chrX_+_56563569 Show fit	13.75	ENST00000338222.7	UBQLN2 Ensembl NCBI GeneCards UniProt Show fit	ubiquilin 2
chr11_-_11353241 Show fit	12.75	ENST00000528848.3	CSNK2A3 Ensembl NCBI GeneCards UniProt Show fit	casein kinase 2 alpha 3
chr13_-_23433735 Show fit	11.98	ENST00000423156.2 ENST00000683210.1 ENST00000682775.1 ENST00000684497.1 ENST00000682944.1 ENST00000683489.1 ENST00000684385.1 ENST00000683680.1	SACS Ensembl NCBI GeneCards UniProt Show fit	sacsin molecular chaperone
chr3_+_142623386 Show fit	11.72	ENST00000337777.7 ENST00000497199.5	PLS1 Ensembl NCBI GeneCards UniProt Show fit	plastin 1
chr12_-_56741535 Show fit	11.01	ENST00000647707.1	ENSG00000285625.1 Ensembl NCBI GeneCards UniProt Show fit	novel protein

Showing 1 to 10 of 141 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.5	26.3	GO:0090084	negative regulation of inclusion body assembly(GO:0090084)
0.2	21.1	GO:0008543	fibroblast growth factor receptor signaling pathway(GO:0008543)
1.5	20.6	GO:0001778	plasma membrane repair(GO:0001778)
0.9	18.6	GO:0032060	bleb assembly(GO:0032060)
0.6	14.9	GO:0051084	'de novo' posttranslational protein folding(GO:0051084)
0.2	14.8	GO:0070125	mitochondrial translational elongation(GO:0070125)
4.8	14.3	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
3.4	13.8	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021)
0.1	12.7	GO:0030307	positive regulation of cell growth(GO:0030307)
2.3	11.7	GO:1902896	terminal web assembly(GO:1902896)

Showing 1 to 10 of 83 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.6	26.3	GO:0070852	cell body fiber(GO:0070852)
0.2	21.4	GO:0071013	catalytic step 2 spliceosome(GO:0071013)
4.1	20.6	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	17.2	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.5	15.3	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
1.8	14.3	GO:0005827	polar microtubule(GO:0005827)
0.1	14.3	GO:0005776	autophagosome(GO:0005776)
0.0	13.9	GO:0000139	Golgi membrane(GO:0000139)
2.0	11.7	GO:1990357	terminal web(GO:1990357)
0.0	11.6	GO:0005874	microtubule(GO:0005874)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
1.0	26.3	GO:0070628	proteasome binding(GO:0070628)
0.7	21.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.5	20.6	GO:0000146	microfilament motor activity(GO:0000146)
0.2	15.7	GO:0070888	E-box binding(GO:0070888)
4.8	14.3	GO:0031208	POZ domain binding(GO:0031208)
2.5	12.5	GO:0052828	phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
0.0	11.4	GO:0031625	ubiquitin protein ligase binding(GO:0031625)
0.3	10.9	GO:0044183	protein binding involved in protein folding(GO:0044183)
0.0	10.4	GO:0003714	transcription corepressor activity(GO:0003714)
2.6	10.3	GO:0008177	succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)

Showing 1 to 10 of 72 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	24.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.2	16.2	PID ERBB4 PATHWAY	ErbB4 signaling events
0.4	14.3	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.3	9.4	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.2	8.0	PID ATM PATHWAY	ATM pathway
0.3	7.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	6.4	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	6.3	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.1	6.3	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	5.7	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt

Showing 1 to 10 of 20 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	21.4	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.1	20.7	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.5	14.4	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.6	12.5	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.3	10.9	REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC	Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1	10.8	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.4	10.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.3	9.4	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2	8.7	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.5	8.0	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint

Showing 1 to 10 of 28 entries

Results for HOXD4

Z-value: 0.85

Motif logo

Transcription factors associated with HOXD4

Activity profile of HOXD4 motif

Sorted Z-values of HOXD4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD4

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: