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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HOXD4

Z-value: 0.85

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Transcription factors associated with HOXD4

Gene Symbol Gene ID Gene Info
HOXD4
ENSG00000170166.6 HOXD4

Activity profile of HOXD4 motif

Sorted Z-values of HOXD4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXD4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr5_-_179617581 21.21 ENST00000523449.5
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1
chr8_-_80029826 15.35 ENST00000519386.5
MRPS28
mitochondrial ribosomal protein S28
chr3_+_159069252 14.70 ENST00000640015.1
ENST00000476809.7
ENST00000485419.7
IQCJ-SCHIP1
IQCJ-SCHIP1 readthrough
chr2_-_224569782 14.33 ENST00000409096.5
CUL3
cullin 3
chr13_-_23433676 14.30 ENST00000682547.1
ENST00000455470.6
ENST00000382292.9
SACS
sacsin molecular chaperone
chrX_+_56563569 13.75 ENST00000338222.7
UBQLN2
ubiquilin 2
chr11_-_11353241 12.75 ENST00000528848.3
CSNK2A3
casein kinase 2 alpha 3
chr13_-_23433735 11.98 ENST00000423156.2
ENST00000683210.1
ENST00000682775.1
ENST00000684497.1
ENST00000682944.1
ENST00000683489.1
ENST00000684385.1
ENST00000683680.1
SACS
sacsin molecular chaperone
chr3_+_142623386 11.72 ENST00000337777.7
ENST00000497199.5
PLS1
plastin 1
chr12_-_56741535 11.01 ENST00000647707.1
ENSG00000285625.1
novel protein
chr21_-_29061351 10.87 ENST00000432178.5
CCT8
chaperonin containing TCP1 subunit 8
chr1_-_17045219 10.29 ENST00000491274.5
SDHB
succinate dehydrogenase complex iron sulfur subunit B
chr19_+_48325522 9.76 ENST00000594198.1
ENST00000270221.11
ENST00000597279.5
ENST00000593437.1
EMP3
epithelial membrane protein 3
chr11_+_102112445 9.62 ENST00000524575.5
YAP1
Yes1 associated transcriptional regulator
chr14_+_61697622 9.38 ENST00000539097.2
HIF1A
hypoxia inducible factor 1 subunit alpha
chr19_+_48325323 8.81 ENST00000596315.5
EMP3
epithelial membrane protein 3
chr12_+_15956585 8.63 ENST00000526530.1
DERA
deoxyribose-phosphate aldolase
chr15_+_80072559 8.44 ENST00000560228.5
ENST00000559835.5
ENST00000559775.5
ENST00000558688.5
ENST00000560392.5
ENST00000560976.5
ENST00000558272.5
ENST00000558390.5
ZFAND6
zinc finger AN1-type containing 6
chr7_+_55365317 8.05 ENST00000254770.3
LANCL2
LanC like 2
chr18_-_36798482 7.96 ENST00000590258.2
TPGS2
tubulin polyglutamylase complex subunit 2
chrX_-_23884017 7.92 ENST00000633372.1
APOO
apolipoprotein O
chr17_-_10549652 7.72 ENST00000245503.10
MYH2
myosin heavy chain 2
chr1_-_86914102 7.63 ENST00000331835.10
ENST00000401030.4
ENST00000370554.5
SELENOF
selenoprotein F
chr17_-_10549612 7.56 ENST00000532183.6
ENST00000397183.6
ENST00000420805.1
MYH2
myosin heavy chain 2
chr4_-_142305935 7.32 ENST00000511838.5
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr1_-_86914319 7.25 ENST00000611507.4
ENST00000616787.4
SELENOF
selenoprotein F
chr2_+_186590022 7.12 ENST00000261023.8
ENST00000374907.7
ITGAV
integrin subunit alpha V
chr7_+_112423137 7.09 ENST00000005558.8
ENST00000621379.4
IFRD1
interferon related developmental regulator 1
chr14_+_77708076 6.88 ENST00000238688.9
ENST00000557342.6
ENST00000557623.5
ENST00000557431.5
ENST00000556831.5
ENST00000556375.5
ENST00000553981.1
SLIRP
SRA stem-loop interacting RNA binding protein
chr7_+_101817601 6.87 ENST00000292535.12
ENST00000546411.7
ENST00000549414.6
ENST00000550008.6
ENST00000556210.1
CUX1
cut like homeobox 1
chr3_+_158801926 6.86 ENST00000622669.4
ENST00000392813.8
ENST00000415822.8
ENST00000651862.1
ENST00000264266.12
MFSD1
major facilitator superfamily domain containing 1
chr7_+_92057602 6.72 ENST00000491695.2
AKAP9
A-kinase anchoring protein 9
chr17_-_75848641 6.50 ENST00000586257.5
WBP2
WW domain binding protein 2
chr1_-_246193727 6.44 ENST00000391836.3
SMYD3
SET and MYND domain containing 3
chr8_+_97644164 6.43 ENST00000336273.8
MTDH
metadherin
chr3_+_69763726 6.34 ENST00000448226.9
MITF
melanocyte inducing transcription factor
chr18_-_24311495 6.29 ENST00000357041.8
OSBPL1A
oxysterol binding protein like 1A
chr2_+_108621260 6.25 ENST00000409441.5
LIMS1
LIM zinc finger domain containing 1
chrX_-_10677720 6.17 ENST00000453318.6
MID1
midline 1
chr9_+_470291 5.96 ENST00000382303.5
KANK1
KN motif and ankyrin repeat domains 1
chr1_+_150067820 5.82 ENST00000419023.3
ENST00000644526.1
VPS45
vacuolar protein sorting 45 homolog
chr4_+_168497066 5.82 ENST00000261509.10
PALLD
palladin, cytoskeletal associated protein
chr5_-_62403506 5.77 ENST00000680062.1
DIMT1
DIMT1 rRNA methyltransferase and ribosome maturation factor
chr9_-_125484490 5.70 ENST00000444226.1
MAPKAP1
MAPK associated protein 1
chr10_-_29736956 5.54 ENST00000674475.1
SVIL
supervillin
chr17_-_10549694 5.32 ENST00000622564.4
MYH2
myosin heavy chain 2
chr12_-_118190510 5.31 ENST00000540561.5
ENST00000537952.1
ENST00000537822.1
TAOK3
TAO kinase 3
chr4_-_142305826 5.23 ENST00000514525.1
INPP4B
inositol polyphosphate-4-phosphatase type II B
chr6_-_36547400 5.05 ENST00000229812.8
STK38
serine/threonine kinase 38
chr1_+_150067668 5.02 ENST00000611412.4
ENST00000644510.2
ENST00000643611.1
VPS45
vacuolar protein sorting 45 homolog
chr5_+_52787899 4.81 ENST00000274311.3
ENST00000282588.7
PELO
ITGA1
pelota mRNA surveillance and ribosome rescue factor
integrin subunit alpha 1
chr2_+_27663441 4.75 ENST00000326019.10
ENST00000613058.4
SLC4A1AP
solute carrier family 4 member 1 adaptor protein
chr3_-_149576203 4.74 ENST00000472417.1
WWTR1
WW domain containing transcription regulator 1
chr6_+_113857333 4.52 ENST00000612661.2
MARCKS
myristoylated alanine rich protein kinase C substrate
chr5_+_141966820 4.45 ENST00000513019.5
ENST00000394519.5
ENST00000356143.5
RNF14
ring finger protein 14
chr1_+_84164962 4.40 ENST00000614872.4
ENST00000394839.6
PRKACB
protein kinase cAMP-activated catalytic subunit beta
chr3_+_173398438 4.27 ENST00000457714.5
NLGN1
neuroligin 1
chr22_-_28711931 4.16 ENST00000434810.5
ENST00000456369.5
CHEK2
checkpoint kinase 2
chrX_-_154371210 3.97 ENST00000369856.8
ENST00000422373.6
ENST00000360319.9
FLNA
filamin A
chr1_+_86914616 3.97 ENST00000370550.10
ENST00000370551.8
HS2ST1
heparan sulfate 2-O-sulfotransferase 1
chr4_+_168497044 3.94 ENST00000505667.6
PALLD
palladin, cytoskeletal associated protein
chr5_-_180072086 3.91 ENST00000261947.4
RNF130
ring finger protein 130
chr15_-_55917129 3.90 ENST00000338963.6
ENST00000508342.5
NEDD4
NEDD4 E3 ubiquitin protein ligase
chr2_-_169573856 3.89 ENST00000453153.7
ENST00000445210.1
FASTKD1
FAST kinase domains 1
chr22_-_28712136 3.83 ENST00000464581.6
CHEK2
checkpoint kinase 2
chr7_-_105269007 3.76 ENST00000357311.7
SRPK2
SRSF protein kinase 2
chr7_+_77798832 3.75 ENST00000415251.6
ENST00000275575.11
PHTF2
putative homeodomain transcription factor 2
chr2_-_74392025 3.46 ENST00000440727.1
ENST00000409240.5
DCTN1
dynactin subunit 1
chr1_-_100894818 3.27 ENST00000370114.8
EXTL2
exostosin like glycosyltransferase 2
chr8_+_23288081 3.21 ENST00000265806.12
ENST00000519952.6
ENST00000518840.6
R3HCC1
R3H domain and coiled-coil containing 1
chr3_+_97821984 3.19 ENST00000389622.7
CRYBG3
crystallin beta-gamma domain containing 3
chr16_+_24537693 3.14 ENST00000564314.5
ENST00000567686.5
RBBP6
RB binding protein 6, ubiquitin ligase
chr17_-_7315312 3.05 ENST00000577040.2
ENST00000389167.9
ENST00000380728.7
GPS2
G protein pathway suppressor 2
chr17_+_21126947 3.00 ENST00000579303.5
DHRS7B
dehydrogenase/reductase 7B
chr1_-_100894775 2.95 ENST00000416479.1
ENST00000370113.7
EXTL2
exostosin like glycosyltransferase 2
chrX_-_120575783 2.81 ENST00000680673.1
CUL4B
cullin 4B
chr7_+_77798750 2.78 ENST00000416283.6
ENST00000422959.6
ENST00000307305.12
ENST00000424760.5
PHTF2
putative homeodomain transcription factor 2
chr7_-_80919017 2.74 ENST00000265361.8
SEMA3C
semaphorin 3C
chr22_-_30246739 2.71 ENST00000403987.3
ENST00000249075.4
LIF
LIF interleukin 6 family cytokine
chr3_-_125055987 2.70 ENST00000311127.9
HEG1
heart development protein with EGF like domains 1
chr12_+_14365661 2.70 ENST00000261168.9
ENST00000538511.5
ENST00000545723.1
ENST00000543189.5
ATF7IP
activating transcription factor 7 interacting protein
chr10_-_14330879 2.66 ENST00000357447.7
FRMD4A
FERM domain containing 4A
chr2_-_98663464 2.53 ENST00000414521.6
MGAT4A
alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A
chr15_-_55917080 2.46 ENST00000506154.1
NEDD4
NEDD4 E3 ubiquitin protein ligase
chr6_+_143677935 2.38 ENST00000440869.6
ENST00000367582.7
ENST00000451827.6
PHACTR2
phosphatase and actin regulator 2
chr7_-_29146436 2.21 ENST00000396276.7
CPVL
carboxypeptidase vitellogenic like
chr10_+_84424919 2.16 ENST00000543283.2
ENST00000494586.5
CCSER2
coiled-coil serine rich protein 2
chr15_+_78873723 2.02 ENST00000559690.5
ENST00000559158.5
MORF4L1
mortality factor 4 like 1
chr6_-_136526472 1.97 ENST00000454590.5
ENST00000432797.6
MAP7
microtubule associated protein 7
chr1_-_9751540 1.94 ENST00000435891.5
CLSTN1
calsyntenin 1
chr3_-_197260369 1.91 ENST00000658155.1
ENST00000453607.5
DLG1
discs large MAGUK scaffold protein 1
chr2_-_70553440 1.85 ENST00000450929.5
TGFA
transforming growth factor alpha
chr11_-_78079819 1.80 ENST00000534029.5
ENST00000525085.1
ENST00000527806.1
ENST00000528164.1
ENST00000281031.5
ENST00000528251.1
ENST00000530054.1
NDUFC2
NDUFC2-KCTD14
NADH:ubiquinone oxidoreductase subunit C2
NDUFC2-KCTD14 readthrough
chr3_+_33114007 1.78 ENST00000320954.11
CRTAP
cartilage associated protein
chr1_+_28438104 1.71 ENST00000633167.1
ENST00000373836.4
PHACTR4
phosphatase and actin regulator 4
chr7_+_138460238 1.66 ENST00000343526.9
TRIM24
tripartite motif containing 24
chr6_-_136526177 1.63 ENST00000617204.4
MAP7
microtubule associated protein 7
chr7_-_29146527 1.57 ENST00000265394.10
CPVL
carboxypeptidase vitellogenic like
chr22_+_41092869 1.55 ENST00000674155.1
EP300
E1A binding protein p300
chr20_-_7940444 1.46 ENST00000378789.4
HAO1
hydroxyacid oxidase 1
chr4_+_73481737 1.41 ENST00000226355.5
AFM
afamin
chr2_-_55296361 1.33 ENST00000647547.1
CCDC88A
coiled-coil domain containing 88A
chr17_-_42980393 1.19 ENST00000409446.8
ENST00000409399.6
ENST00000421990.7
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 like
PTGES3L-AARSD1 readthrough
chr2_-_182242031 1.19 ENST00000358139.6
PDE1A
phosphodiesterase 1A
chr16_-_29899532 1.17 ENST00000308713.9
ENST00000617533.5
SEZ6L2
seizure related 6 homolog like 2
chr12_-_86256299 1.03 ENST00000552808.6
ENST00000547225.5
MGAT4C
MGAT4 family member C
chr18_-_21703688 0.96 ENST00000584464.1
ENST00000578270.5
ABHD3
abhydrolase domain containing 3, phospholipase
chr4_-_39977836 0.94 ENST00000303538.13
ENST00000503396.5
PDS5A
PDS5 cohesin associated factor A
chr6_-_87095059 0.93 ENST00000369582.6
ENST00000610310.3
ENST00000630630.2
ENST00000627148.3
ENST00000625577.1
CGA
glycoprotein hormones, alpha polypeptide
chr1_+_67166448 0.92 ENST00000347310.10
IL23R
interleukin 23 receptor
chr13_+_19633642 0.91 ENST00000361479.10
MPHOSPH8
M-phase phosphoprotein 8
chr12_+_9827517 0.89 ENST00000537723.5
KLRF1
killer cell lectin like receptor F1
chr5_+_141382702 0.88 ENST00000617050.1
ENST00000518325.2
PCDHGA7
protocadherin gamma subfamily A, 7
chr3_-_165078480 0.84 ENST00000264382.8
SI
sucrase-isomaltase
chr12_+_41437680 0.75 ENST00000649474.1
ENST00000539469.6
ENST00000298919.7
PDZRN4
PDZ domain containing ring finger 4
chr8_-_69834970 0.67 ENST00000260126.9
SLCO5A1
solute carrier organic anion transporter family member 5A1
chr11_+_66011994 0.66 ENST00000312134.3
CST6
cystatin E/M
chr14_-_99480831 0.64 ENST00000331768.10
ENST00000630307.2
SETD3
SET domain containing 3, actin histidine methyltransferase
chrX_+_77910656 0.56 ENST00000343533.9
ENST00000341514.11
ENST00000645454.1
ENST00000642651.1
ENST00000644362.1
ATP7A
PGK1
ATPase copper transporting alpha
phosphoglycerate kinase 1
chr11_+_92969651 0.54 ENST00000257068.3
ENST00000528076.1
MTNR1B
melatonin receptor 1B
chr4_-_26490453 0.52 ENST00000295589.4
CCKAR
cholecystokinin A receptor
chr4_-_84966637 0.51 ENST00000295888.9
WDFY3
WD repeat and FYVE domain containing 3
chr2_-_213151590 0.50 ENST00000374319.8
ENST00000457361.5
ENST00000451136.6
ENST00000434687.6
IKZF2
IKAROS family zinc finger 2
chr5_-_139198358 0.47 ENST00000394817.7
SIL1
SIL1 nucleotide exchange factor
chr2_+_169584332 0.47 ENST00000414307.6
ENST00000433207.6
ENST00000678088.1
ENST00000676508.1
ENST00000260970.8
ENST00000409714.7
PPIG
peptidylprolyl isomerase G
chr12_-_10420550 0.38 ENST00000381903.2
ENST00000396439.7
KLRC3
killer cell lectin like receptor C3
chr2_-_165204042 0.31 ENST00000283254.12
ENST00000453007.1
SCN3A
sodium voltage-gated channel alpha subunit 3
chr12_-_86256267 0.29 ENST00000620241.4
MGAT4C
MGAT4 family member C
chr6_+_42746958 0.28 ENST00000614467.4
BICRAL
BRD4 interacting chromatin remodeling complex associated protein like
chr12_-_48852153 0.24 ENST00000308025.8
DDX23
DEAD-box helicase 23
chr5_+_68290637 0.19 ENST00000336483.9
PIK3R1
phosphoinositide-3-kinase regulatory subunit 1
chr9_+_117704382 0.18 ENST00000646089.1
ENST00000355622.8
ENSG00000285082.2
TLR4
novel protein
toll like receptor 4
chr12_+_112906777 0.17 ENST00000452357.7
ENST00000445409.7
OAS1
2'-5'-oligoadenylate synthetase 1
chr15_+_64094060 0.14 ENST00000560829.5
SNX1
sorting nexin 1
chr6_+_46793379 0.14 ENST00000230588.9
ENST00000611727.2
MEP1A
meprin A subunit alpha
chr1_+_210328244 0.11 ENST00000541565.5
ENST00000413764.6
HHAT
hedgehog acyltransferase
chr14_+_22598224 0.10 ENST00000428304.6
ENST00000542041.1
ENST00000216327.10
ABHD4
abhydrolase domain containing 4, N-acyl phospholipase B
chr3_-_114178698 0.10 ENST00000467632.5
DRD3
dopamine receptor D3
chr19_-_13953302 0.07 ENST00000585607.1
ENST00000538517.6
ENST00000587458.1
ENST00000538371.6
PODNL1
podocan like 1
chr7_-_22193824 0.07 ENST00000401957.6
RAPGEF5
Rap guanine nucleotide exchange factor 5
chr2_+_71453538 0.02 ENST00000258104.8
DYSF
dysferlin

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.3 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
3.4 13.8 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186) regulation of G-protein coupled receptor internalization(GO:1904020) negative regulation of G-protein coupled receptor internalization(GO:1904021)
2.7 8.0 GO:1901421 positive regulation of response to alcohol(GO:1901421)
2.7 8.0 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
2.4 7.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
2.4 7.1 GO:0007518 myoblast fate determination(GO:0007518)
2.3 11.7 GO:1902896 terminal web assembly(GO:1902896)
2.2 8.6 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
2.1 6.4 GO:0019089 negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage(GO:0010768) transmission of virus(GO:0019089) dissemination or transmission of symbiont from host(GO:0044007) dissemination or transmission of organism from other organism involved in symbiotic interaction(GO:0051821)
1.7 6.9 GO:0000961 negative regulation of mitochondrial RNA catabolic process(GO:0000961)
1.6 9.4 GO:0061030 epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
1.5 6.0 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
1.5 20.6 GO:0001778 plasma membrane repair(GO:0001778)
1.5 26.3 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
1.3 4.0 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
1.2 6.2 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
1.1 5.7 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
1.1 6.5 GO:0071442 positive regulation of histone H3-K14 acetylation(GO:0071442)
1.1 9.6 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
1.1 4.3 GO:0098923 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543)
1.0 4.8 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.9 2.7 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.9 18.6 GO:0032060 bleb assembly(GO:0032060)
0.8 10.9 GO:1904869 regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871)
0.7 4.4 GO:0097338 response to clozapine(GO:0097338)
0.6 3.8 GO:0035063 nuclear speck organization(GO:0035063)
0.6 7.9 GO:0042407 cristae formation(GO:0042407)
0.6 1.8 GO:1901874 negative regulation of post-translational protein modification(GO:1901874)
0.6 3.5 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
0.6 1.7 GO:2001045 closure of optic fissure(GO:0061386) negative regulation of integrin-mediated signaling pathway(GO:2001045)
0.6 14.9 GO:0051084 'de novo' posttranslational protein folding(GO:0051084)
0.5 6.7 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.5 9.8 GO:0003334 keratinocyte development(GO:0003334)
0.5 10.3 GO:0006105 succinate metabolic process(GO:0006105)
0.5 2.7 GO:0003350 pulmonary myocardium development(GO:0003350)
0.4 6.2 GO:0035372 protein localization to microtubule(GO:0035372)
0.4 1.7 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.4 4.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.4 2.7 GO:0090269 fibroblast growth factor production(GO:0090269) regulation of fibroblast growth factor production(GO:0090270)
0.3 1.6 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.3 0.9 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.3 8.4 GO:0072662 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.2 5.8 GO:0031167 rRNA methylation(GO:0031167)
0.2 1.3 GO:1903566 positive regulation of protein localization to cilium(GO:1903566)
0.2 4.5 GO:0051764 actin crosslink formation(GO:0051764)
0.2 6.9 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.2 14.8 GO:0070125 mitochondrial translational elongation(GO:0070125)
0.2 5.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.2 0.6 GO:0071284 copper ion export(GO:0060003) cellular response to lead ion(GO:0071284) regulation of electron carrier activity(GO:1904732)
0.2 10.8 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.2 1.5 GO:0009441 glycolate metabolic process(GO:0009441)
0.2 21.1 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.1 6.3 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.1 2.8 GO:0070914 UV-damage excision repair(GO:0070914)
0.1 6.4 GO:0014904 myotube cell development(GO:0014904)
0.1 6.3 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.1 9.0 GO:2000142 regulation of DNA-templated transcription, initiation(GO:2000142)
0.1 10.2 GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.1 1.9 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.1 0.8 GO:0044245 polysaccharide digestion(GO:0044245)
0.1 5.6 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 4.4 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.1 2.7 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.1 0.5 GO:0035973 aggrephagy(GO:0035973)
0.1 2.5 GO:0006491 N-glycan processing(GO:0006491)
0.1 0.2 GO:0070426 negative regulation of interleukin-23 production(GO:0032707) positive regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070426) positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070434)
0.1 6.1 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.1 3.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 5.1 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.1 2.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 1.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 12.7 GO:0030307 positive regulation of cell growth(GO:0030307)
0.0 0.9 GO:0044030 regulation of DNA methylation(GO:0044030)
0.0 0.9 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.6 GO:0018026 histone H3-K36 methylation(GO:0010452) peptidyl-lysine monomethylation(GO:0018026)
0.0 3.1 GO:0061053 somite development(GO:0061053)
0.0 2.2 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 1.8 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0 1.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.0 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.0 0.7 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.0 0.1 GO:0034498 early endosome to Golgi transport(GO:0034498)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 20.6 GO:0005826 actomyosin contractile ring(GO:0005826)
3.2 9.6 GO:0071148 TEAD-1-YAP complex(GO:0071148)
2.6 26.3 GO:0070852 cell body fiber(GO:0070852)
2.4 7.1 GO:0034686 integrin alphav-beta8 complex(GO:0034686)
2.1 10.3 GO:0005749 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
2.0 11.7 GO:1990357 terminal web(GO:1990357)
1.8 14.3 GO:0005827 polar microtubule(GO:0005827)
1.7 6.7 GO:0044307 dendritic branch(GO:0044307)
1.3 7.9 GO:0061617 MICOS complex(GO:0061617)
1.2 4.8 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.8 10.9 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.8 4.0 GO:0031523 Myb complex(GO:0031523)
0.6 6.4 GO:0046581 intercellular canaliculus(GO:0046581)
0.6 5.5 GO:0036449 microtubule minus-end(GO:0036449)
0.5 15.3 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.3 1.7 GO:0005726 perichromatin fibrils(GO:0005726)
0.3 0.9 GO:0072536 interleukin-23 receptor complex(GO:0072536)
0.3 4.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.3 4.5 GO:0043073 germ cell nucleus(GO:0043073)
0.3 5.7 GO:0031932 TORC2 complex(GO:0031932)
0.3 2.8 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.2 3.5 GO:0005869 dynactin complex(GO:0005869)
0.2 4.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 6.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 9.8 GO:0002102 podosome(GO:0002102)
0.2 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 21.4 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.2 9.4 GO:1904115 axon cytoplasm(GO:1904115)
0.1 3.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 14.3 GO:0005776 autophagosome(GO:0005776)
0.1 2.0 GO:0016580 Sin3 complex(GO:0016580)
0.1 1.9 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.1 6.9 GO:0036126 sperm flagellum(GO:0036126)
0.1 6.2 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 8.0 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.1 2.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 17.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 8.0 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 1.8 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 0.2 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
0.0 11.6 GO:0005874 microtubule(GO:0005874)
0.0 3.7 GO:0032587 ruffle membrane(GO:0032587)
0.0 6.9 GO:0005770 late endosome(GO:0005770)
0.0 1.5 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 13.9 GO:0000139 Golgi membrane(GO:0000139)
0.0 4.4 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 2.4 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 6.8 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.3 GO:0005814 centriole(GO:0005814)
0.0 1.7 GO:0030027 lamellipodium(GO:0030027)
0.0 6.3 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.8 14.3 GO:0031208 POZ domain binding(GO:0031208)
2.6 10.3 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177) 3 iron, 4 sulfur cluster binding(GO:0051538)
2.5 12.5 GO:0052828 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) inositol-1,3,4-trisphosphate 4-phosphatase activity(GO:0017161) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) inositol-3,4-bisphosphate 4-phosphatase activity(GO:0052828)
2.1 6.2 GO:0035248 alpha-1,4-N-acetylgalactosaminyltransferase activity(GO:0035248)
1.9 5.8 GO:0008988 rRNA (adenine-N6-)-methyltransferase activity(GO:0008988)
1.8 7.1 GO:1990430 extracellular matrix protein binding(GO:1990430)
1.0 26.3 GO:0070628 proteasome binding(GO:0070628)
0.9 6.4 GO:0050815 phosphoserine binding(GO:0050815)
0.8 4.0 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.7 21.2 GO:0008266 poly(U) RNA binding(GO:0008266)
0.7 8.0 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.6 6.4 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.6 4.8 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.5 3.8 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.5 20.6 GO:0000146 microfilament motor activity(GO:0000146)
0.5 1.5 GO:0052852 (S)-2-hydroxy-acid oxidase activity(GO:0003973) very-long-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052852) long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity(GO:0052853) medium-chain-(S)-2-hydroxy-acid oxidase activity(GO:0052854)
0.5 1.4 GO:0008431 vitamin E binding(GO:0008431)
0.4 9.8 GO:0051371 muscle alpha-actinin binding(GO:0051371)
0.4 8.6 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.3 1.0 GO:0052739 phosphatidylserine 1-acylhydrolase activity(GO:0052739)
0.3 9.6 GO:0070064 proline-rich region binding(GO:0070064)
0.3 0.9 GO:0042019 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.3 4.0 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.3 10.9 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.3 4.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.3 5.7 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.3 5.1 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.3 1.6 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.3 4.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 2.7 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 15.7 GO:0070888 E-box binding(GO:0070888)
0.2 1.2 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.2 3.8 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 0.6 GO:0004008 copper-exporting ATPase activity(GO:0004008) phosphoglycerate kinase activity(GO:0004618) copper-transporting ATPase activity(GO:0043682)
0.2 0.5 GO:0008502 melatonin receptor activity(GO:0008502)
0.2 6.3 GO:0015248 sterol transporter activity(GO:0015248)
0.2 0.8 GO:0004558 alpha-1,4-glucosidase activity(GO:0004558)
0.2 4.2 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.2 6.4 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 1.7 GO:0072542 protein phosphatase activator activity(GO:0072542)
0.1 4.9 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 4.4 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.1 7.6 GO:0031593 polyubiquitin binding(GO:0031593)
0.1 1.9 GO:0097016 L27 domain binding(GO:0097016)
0.1 3.8 GO:0071889 14-3-3 protein binding(GO:0071889)
0.1 6.5 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.1 3.5 GO:0070840 dynein complex binding(GO:0070840)
0.1 0.6 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.1 4.2 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.3 GO:0043422 protein kinase B binding(GO:0043422)
0.1 0.9 GO:0032393 MHC class I receptor activity(GO:0032393)
0.1 6.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.5 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.1 1.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 9.6 GO:0051015 actin filament binding(GO:0051015)
0.0 6.0 GO:0008013 beta-catenin binding(GO:0008013)
0.0 10.4 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 1.9 GO:0019894 kinesin binding(GO:0019894)
0.0 1.8 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0 11.4 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.5 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 6.9 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.0 0.2 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.7 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 3.1 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 3.9 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 4.7 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 2.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.1 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0 0.2 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.0 0.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 24.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.4 14.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.3 9.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 7.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.2 16.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.2 4.8 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 8.0 PID ATM PATHWAY ATM pathway
0.2 5.3 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.1 5.7 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.1 4.4 PID IL3 PATHWAY IL3-mediated signaling events
0.1 6.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.1 6.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 4.3 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 3.5 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 6.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 5.5 PID AR PATHWAY Coregulation of Androgen receptor activity
0.0 1.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.9 PID IL23 PATHWAY IL23-mediated signaling events
0.0 0.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.9 PID REG GR PATHWAY Glucocorticoid receptor regulatory network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.5 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.5 14.4 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.5 8.0 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.4 7.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.4 10.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.3 10.9 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.3 3.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.3 9.4 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 8.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.2 6.7 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.2 6.3 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.2 5.7 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 3.8 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.1 1.6 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1 4.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.1 21.4 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 4.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 4.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 20.7 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 10.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 1.2 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.1 0.8 REACTOME DIGESTION OF DIETARY CARBOHYDRATE Genes involved in Digestion of dietary carbohydrate
0.1 0.9 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.0 3.5 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.9 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 1.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.2 REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon