ISMARA results: HSF1

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GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for HSF1

Z-value: 0.90

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Transcription factors associated with HSF1

Gene Symbol	Gene ID	Gene Info
HSF1 Ensembl NCBI GeneCards UniProt	ENSG00000185122.11	HSF1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HSF1	hg38_v1_chr8_+_144291581_144291617	0.00	9.6e-01	Click!

Activity profile of HSF1 motif

Sorted Z-values of HSF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

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Promoter	Score	Transcript	Gene	Gene Info
chr4_-_83109843 Show fit	13.28	ENST00000411416.6	PLAC8 Ensembl NCBI GeneCards UniProt Show fit	placenta associated 8
chr1_+_110873135 Show fit	11.69	ENST00000271324.6	CD53 Ensembl NCBI GeneCards UniProt Show fit	CD53 molecule
chr1_-_153390976 Show fit	10.91	ENST00000368732.5 ENST00000368733.4	S100A8 Ensembl NCBI GeneCards UniProt Show fit	S100 calcium binding protein A8
chr12_-_52517929 Show fit	10.64	ENST00000548409.5	KRT5 Ensembl NCBI GeneCards UniProt Show fit	keratin 5
chr2_-_89213917 Show fit	10.06	ENST00000498435.1	IGKV1-27 Ensembl NCBI GeneCards UniProt Show fit	immunoglobulin kappa variable 1-27
chr11_-_102452758 Show fit	8.97	ENST00000398136.7 ENST00000361236.7	TMEM123 Ensembl NCBI GeneCards UniProt Show fit	transmembrane protein 123
chr6_+_32637419 Show fit	8.92	ENST00000374949.2	HLA-DQA1 Ensembl NCBI GeneCards UniProt Show fit	major histocompatibility complex, class II, DQ alpha 1
chr19_-_2051224 Show fit	8.27	ENST00000309340.11 ENST00000589534.2 ENST00000250896.9 ENST00000589509.5	MKNK2 Ensembl NCBI GeneCards UniProt Show fit	MAPK interacting serine/threonine kinase 2
chr17_-_41505597 Show fit	8.15	ENST00000336861.7 ENST00000246635.8 ENST00000587544.5 ENST00000587435.1	KRT13 Ensembl NCBI GeneCards UniProt Show fit	keratin 13
chr5_+_119354771 Show fit	7.70	ENST00000503646.1	TNFAIP8 Ensembl NCBI GeneCards UniProt Show fit	TNF alpha induced protein 8

Showing 1 to 10 of 200 entries

Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	24.7	GO:0002250	adaptive immune response(GO:0002250)
0.2	20.5	GO:0031295	T cell costimulation(GO:0031295)
0.6	14.9	GO:0044130	negative regulation of growth of symbiont in host(GO:0044130)
0.7	12.8	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.2	12.0	GO:0006910	phagocytosis, recognition(GO:0006910)
0.4	11.7	GO:1901741	positive regulation of myoblast fusion(GO:1901741)
0.1	11.2	GO:0006958	complement activation, classical pathway(GO:0006958)
0.4	11.0	GO:0031581	hemidesmosome assembly(GO:0031581)
1.0	10.4	GO:0032119	sequestering of zinc ion(GO:0032119)
0.1	9.0	GO:0006695	cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)

Showing 1 to 10 of 239 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	23.7	GO:0042613	MHC class II protein complex(GO:0042613)
0.1	22.7	GO:0101002	ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.2	19.3	GO:0035579	specific granule membrane(GO:0035579)
0.4	18.6	GO:0045095	keratin filament(GO:0045095)
0.2	17.4	GO:0001772	immunological synapse(GO:0001772)
0.1	17.3	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	17.3	GO:0005615	extracellular space(GO:0005615)
0.0	13.2	GO:0009897	external side of plasma membrane(GO:0009897)
0.2	12.0	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.3	10.4	GO:0030687	preribosome, large subunit precursor(GO:0030687)

Showing 1 to 10 of 106 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	17.9	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1	17.0	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.1	16.0	GO:0032395	MHC class II receptor activity(GO:0032395)
0.1	15.7	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1	14.9	GO:0003823	antigen binding(GO:0003823)
0.2	12.0	GO:0034987	immunoglobulin receptor binding(GO:0034987)
3.6	10.9	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.1	10.2	GO:0003735	structural constituent of ribosome(GO:0003735)
0.1	10.1	GO:0097110	scaffold protein binding(GO:0097110)
3.3	10.0	GO:0050613	delta14-sterol reductase activity(GO:0050613)

Showing 1 to 10 of 183 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	20.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	14.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	10.0	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.1	8.7	ST B CELL ANTIGEN RECEPTOR	B Cell Antigen Receptor
0.1	8.1	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.2	8.0	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.1	7.7	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	7.6	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.1	7.0	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.1	6.5	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Showing 1 to 10 of 46 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	25.0	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.2	19.6	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.3	13.5	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.1	10.0	REACTOME TRANS GOLGI NETWORK VESICLE BUDDING	Genes involved in trans-Golgi Network Vesicle Budding
0.1	9.4	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	8.3	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.1	8.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.3	7.6	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.1	7.5	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.1	7.3	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)

Showing 1 to 10 of 75 entries

Results for HSF1

Z-value: 0.90

Motif logo

Transcription factors associated with HSF1

Activity-expression correlation:

Activity profile of HSF1 motif

Sorted Z-values of HSF1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HSF1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: